ID Q9QYV3_RAT Unreviewed; 1013 AA.
AC Q9QYV3;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=C3G protein {ECO:0000313|EMBL:CAB59566.1};
DE Flags: Fragment;
GN Name=c3g {ECO:0000313|EMBL:CAB59566.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAB59566.1};
RN [1] {ECO:0000313|EMBL:CAB59566.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague Dawley {ECO:0000313|EMBL:CAB59566.1};
RX PubMed=10492401; DOI=10.1089/104454999314980;
RA Shivakrupa A., Singh R., Swarup G.;
RT "Identification of a novel splice variant of C3G which shows tissue-
RT specific expression.";
RL DNA Cell Biol. 18:701-708(1999).
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DR EMBL; AJ249986; CAB59566.1; -; mRNA.
DR AlphaFoldDB; Q9QYV3; -.
DR CORUM; Q9QYV3; -.
DR iPTMnet; Q9QYV3; -.
DR PhosphoSitePlus; Q9QYV3; -.
DR UCSC; RGD:619793; rat.
DR PhylomeDB; Q9QYV3; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 623..745
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 775..1000
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 101..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAB59566.1"
SQ SEQUENCE 1013 AA; 113178 MW; 6336066FCD338E06 CRC64;
FKTIVDKMAI DKKVLEMLPG SASKVLEAIL PLVQTDPRIQ HSSALSSCYS RVYQSLANLI
RWSDQVMLEG VNSEDKEMVT TVKGVIKAVL DGVKELVRIT IEKQGRPSPT SPVKPSSPAS
KPDGQPELPL TEREMEILNK TSVSPSTELL PDSTSEEVAP PKPPLPGIRV VDNSPPALPP
KKRQSAPSPT RVAVVAPMSR AVSGSSLPVG INRQDFDVEC YTQRRLSGGS RSCGGESPRL
SPCSSTGKLS RSDEQLSSLD RDSGQCSRNT SCETLDHYDP DYEFLQQDLS NADQTPPQAA
CNLSPLPESM GESGPPFVGY SFQLPLGSCL QQDGQQTDTP PALPEKKRRS AVSQTTDSSG
CRVSYERHPS QYDNISEDDL QNPAQPVSYP PFAAILPFQQ GASSTPVEFV GDFSVPESAG
DPEKPPPLPE KKNKHMLAYM QLLEDYSEPQ PSMFYQTPQS EHIYQQKNKM LMEVYGFSDS
FCGSDSTQEL APPPALPPKQ RQLASYAASS FSVSHCVQQT KVAFTPEDGS AAQGLSVSVS
NSFLNRHGSL PVPSEPPSGK DGHPRDLSVS SASGKDSREN GERSPKSLDA LESAQSEEEV
DELSLIDHNE IMARLTLKQE GDDGPDVRGG SGDILLVHAT ETDRKDLVLY CEAFLTTYRT
FISPEELIKK LQCRYEKFSP FADTFKKRVS KNTFFVLVRV VDELCLVELT EEILKLLMEL
VFRLVCSGEL SLARVLRKNI LDKVDQKKLL RCAHSDQPLA ARGVAARPGT LHDFHSHEIA
EQLTLLDAEL FYKIEIPEVL LWAKEQNEEL KSPNLTQFTE HFNNMSYWVR SIIMLQEKAQ
DRERLLLKFI KIMKHLRKLN NFNSYLAILS ALDSAPIRRL EWQRQTSEGL AEYCTLIDSS
SSFRAYRAAL SEVEPPCIPY LGLILQDLTF VHLGNPDYID GKVNFSKRWQ QFNILDSMRC
FQQVHYEIRR NDDIINFFND FSDHLAEEAL WELSLKIKPR NITRRKTDRE EKT
//
