ID Q9RGC2_PSEAI Unreviewed; 281 AA.
AC Q9RGC2;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA6 {ECO:0000313|EMBL:AAD54217.1};
GN ORFNames=DY940_34705 {ECO:0000313|EMBL:RTS35927.1};
OS Pseudomonas aeruginosa.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=287 {ECO:0000313|EMBL:AAD54217.1};
RN [1] {ECO:0000313|EMBL:AAD54217.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JES {ECO:0000313|EMBL:AAD54217.1};
RX PubMed=10673049; DOI=10.1016/S0167-4781(99)00202-X;
RA Naas T., Poirel L., Nordmann P.;
RT "Molecular characterisation of In51, a class 1 integron containing a novel
RT aminoglycoside adenylyltransferase gene cassette, aadA6, in Pseudomonas
RT aeruginosa.";
RL Biochim. Biophys. Acta 1489:445-451(1999).
RN [2] {ECO:0000313|EMBL:AAR22403.1}
RP NUCLEOTIDE SEQUENCE.
RA Neonakis I.K., Scoulica E.V., Tselentis Y.J.;
RT "Genetic analysis of a class I integron containing a VIM-4 Metallo-Beta-
RT Lactamase gene cassette in Pseudomonas aeruginosa.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAS20536.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=10.2 {ECO:0000313|EMBL:AAS20536.1};
RX PubMed=15328086; DOI=10.1128/AAC.48.9.3284-3290.2004;
RA Aubert D., Girlich D., Naas T., Nagarajan S., Nordmann P.;
RT "Functional and structural characterization of the genetic environment of
RT an extended-spectrum beta-lactamase blaVEB gene from a Pseudomonas
RT aeruginosa isolate obtained in India.";
RL Antimicrob. Agents Chemother. 48:3284-3290(2004).
RN [4] {ECO:0000313|EMBL:CAH25323.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=105MG {ECO:0000313|EMBL:CAH25323.1};
RA Colinon C.;
RT "Class I integrons from Pseudomonas aeruginosa carrying original cassette
RT arrays.";
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:ABA42957.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MB197 {ECO:0000313|EMBL:ABA42957.1};
RA Libisch B., Gacs M., Fuzi M.;
RT "First outbreak of VIM-producing P. aeruginosa clinical isolates in
RT Hungary.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:CAJ32504.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIPH2611/04 {ECO:0000313|EMBL:CAJ32504.1};
RA Gniadkowski M.T.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:CAJ32504.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NIPH2611/04 {ECO:0000313|EMBL:CAJ32504.1};
RX PubMed=16495246; DOI=10.1128/AAC.50.3.880-886.2006;
RA Fiett J., Baraniak A., Mrowka A., Fleischer M., Drulis-Kawa Z., Naumiuk L.,
RA Samet A., Hryniewicz W., Gniadkowski M.;
RT "Molecular epidemiology of acquired-metallo-beta-lactamase-producing
RT bacteria in Poland.";
RL Antimicrob. Agents Chemother. 50:880-886(2006).
RN [8] {ECO:0000313|EMBL:ABC70303.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16641445; DOI=10.1128/AAC.50.5.1745-1752.2006;
RA Naas T., Aubert D., Lambert T., Nordmann P.;
RT "Complex genetic structures with repeated elements, a sul-type class 1
RT integron, and the blaVEB extended-spectrum beta-lactamase gene.";
RL Antimicrob. Agents Chemother. 50:1745-1752(2006).
RN [9] {ECO:0000313|EMBL:AAZ07712.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17122024; DOI=10.1128/JCM.01318-06;
RA Gu B., Tong M., Zhao W., Liu G., Ning M., Pan S., Zhao W.;
RT "Prevalence and characterization of class I integrons among Pseudomonas
RT aeruginosa and Acinetobacter baumannii isolates from patients in Nanjing,
RT China.";
RL J. Clin. Microbiol. 45:241-243(2007).
RN [10] {ECO:0000313|EMBL:ACF33406.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=57006 {ECO:0000313|EMBL:ACF33406.1};
RA Ratkai C., Quinteira S., Grosso F., Nagy E., Peixe L.;
RT "Characterization of class I integrons from Pseudomonas aeruginosa clinical
RT isolates from Hungary.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:ACN50173.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=886/04 {ECO:0000313|EMBL:ACN50173.1};
RA Silva M.T., Mamizuka E.M., Lincopan N.;
RT "Extended-spectrum beta-lactamase (ESBL)-producing Pseudomonas aeruginosa
RT from southeastern Brazil.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:ACQ45453.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MASTI302 {ECO:0000313|EMBL:ACQ45453.1};
RA Shahcheraghi F., Badmasti F., Feizabadi M.M.;
RT "Molecular characterization of class 1 integrons in MDR Pseudomonas
RT aeruginosa isolated from clinical settings in Iran, Tehran.";
RL FEMS Immunol. Med. Microbiol. 58:421-425(2010).
RN [13] {ECO:0000313|EMBL:ACY07921.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3534 {ECO:0000313|EMBL:ACY07921.1};
RX PubMed=20617927; DOI=10.1089/mdr.2010.0017;
RA Garza-Ramos J.U., Sanchez-Martinez G., Barajas J.M., Suarez S.,
RA Sanchez-Perez A., Rojas-Moreno T., Carrillo-Quiroz B., Silva-Sanchez J.;
RT "Variability of the bla(IMP-15)-containing integrons, highly related to
RT In95, on an endemic clone of Pseudomonas aeruginosa in Mexico.";
RL Microb. Drug Resist. 16:191-195(2010).
RN [14] {ECO:0000313|EMBL:ADZ16827.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K-468 {ECO:0000313|EMBL:ADZ16827.1};
RA Kuzhelnaya E.N., Pryamchuk S.D., Fursova N.K., Svetoch E.A.;
RL Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:CBH19535.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PS 297 {ECO:0000313|EMBL:CBH19535.1};
RA Borgianni L., Prandi S., Salden L., Hanson N.D., Rossolini G.M.,
RA Docquier J.-D.;
RT "Genetic Context and Biochemical Characterization of the IMP-18
RT Metallo- E2-Lactamase Identified in a Pseudomonas aeruginosa Isolate from
RT the United States.";
RL Antimicrob. Agents Chemother. 55:140-145(2011).
RN [16] {ECO:0000313|EMBL:AET25360.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C79 {ECO:0000313|EMBL:AET25360.1};
RX PubMed=22271862; DOI=10.1128/AAC.06048-11;
RA Martinez E., Marquez C., Ingold A., Merlino J., Djordjevic S.P.,
RA Stokes H.W., Roy Chowdhury P.;
RT "Diverse Mobilized Class 1 Integrons Are Common in the Chromosomes of
RT Pathogenic Pseudomonas aeruginosa Clinical Isolates.";
RL Antimicrob. Agents Chemother. 56:2169-2172(2012).
RN [17] {ECO:0000313|EMBL:AFQ94779.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ODM-24 {ECO:0000313|EMBL:AFQ94779.1};
RX PubMed=24143920;
RA Odumosu B.T., Adeniyi B.A., Chandra R.;
RT "Analysis of integrons and associated gene cassettes in clinical isolates
RT of multidrug resistant Pseudomonas aeruginosa from Southwest Nigeria.";
RL Ann. Clin. Microbiol. Antimicrob. 12:29-29(2013).
RN [18] {ECO:0000313|EMBL:CCO61942.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MMA83 {ECO:0000313|EMBL:CCO61942.1};
RX PubMed=23612199; DOI=10.1128/AAC.02312-12;
RA Jovcic B., Lepsanovic Z., Begovic J., Rakonjac B., Perovanovic J.,
RA Topisirovic L., Kojic M.;
RT "The Clinical Isolate Pseudomonas aeruginosa MMA83 Carries Two Copies of
RT the blaNDM-1 Gene in a Novel Genetic Context.";
RL Antimicrob. Agents Chemother. 57:3405-3407(2013).
RN [19] {ECO:0000313|EMBL:AGI04223.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HIABP11 {ECO:0000313|EMBL:AGI04223.1};
RX PubMed=23612200; DOI=10.1128/AAC.02334-12;
RA Janvier F., Jeannot K., Tesse S., Robert-Nicoud M., Delacour H., Rapp C.,
RA Merens A.;
RT "Molecular Characterization of blaNDM-1 in a Sequence Type 235 Pseudomonas
RT aeruginosa Isolate from France.";
RL Antimicrob. Agents Chemother. 57:3408-3411(2013).
RN [20] {ECO:0000313|EMBL:AFI57797.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YMC/Ansorp PAE A61 {ECO:0000313|EMBL:AFI57797.1};
RX PubMed=23843299; DOI=10.1093/jac/dkt269;
RA Kim M.J., Bae I.K., Jeong S.H., Kim S.H., Song J.H., Choi J.Y., Yoon S.S.,
RA Thamlikitkul V., Hsueh P.R., Yasin R.M., Lalitha M.K., Lee K.;
RT "Dissemination of metallo-?-lactamase-producing Pseudomonas aeruginosa of
RT sequence type 235 in Asian countries.";
RL J. Antimicrob. Chemother. 68:2820-2824(2013).
RN [21] {ECO:0000313|EMBL:AID65189.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Pa7 {ECO:0000313|EMBL:AID65189.1};
RA Santos C., Ramalheira E., Duarte G., Mendo S.;
RT "Prevalence of integrons in hospital environment.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [22] {ECO:0000313|EMBL:AKR15737.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B-953/14 {ECO:0000313|EMBL:AKR15737.1};
RA Zhang J.;
RT "Establishment of an Ehrlichia FRET-qPCR to investigate the prevalence of
RT ehrlichiosis in ruminants from five Caribbean islands.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [23] {ECO:0000313|EMBL:RTS35927.1, ECO:0000313|Proteomes:UP000276985}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN6241 {ECO:0000313|EMBL:RTS35927.1,
RC ECO:0000313|Proteomes:UP000276985};
RA Snesrud E., Mcgann P.;
RT "Pseudomonas aeruginosa Diversity Panel.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF140629; AAD54217.1; -; Genomic_DNA.
DR EMBL; AY460181; AAR22403.1; -; Genomic_DNA.
DR EMBL; AY444814; AAS20536.1; -; Genomic_DNA.
DR EMBL; DQ091179; AAZ07712.1; -; Genomic_DNA.
DR EMBL; DQ157702; ABA42957.1; -; Genomic_DNA.
DR EMBL; DQ315788; ABC70303.1; -; Genomic_DNA.
DR EMBL; EU819088; ACF33406.1; -; Genomic_DNA.
DR EMBL; FJ695218; ACN50173.1; -; Genomic_DNA.
DR EMBL; FJ908756; ACQ45453.1; -; Genomic_DNA.
DR EMBL; GQ856541; ACY07921.1; -; Genomic_DNA.
DR EMBL; HQ832477; ADZ16827.1; -; Genomic_DNA.
DR EMBL; JF826498; AET25360.1; -; Genomic_DNA.
DR EMBL; JQ629931; AFI57797.1; -; Genomic_DNA.
DR EMBL; JX195555; AFQ94779.1; -; Genomic_DNA.
DR EMBL; KC170992; AGI04223.1; -; Genomic_DNA.
DR EMBL; KJ679405; AID65189.1; -; Genomic_DNA.
DR EMBL; KP713392; AKR15737.1; -; Genomic_DNA.
DR EMBL; AJ812570; CAH25323.1; -; Genomic_DNA.
DR EMBL; AM087411; CAJ32504.1; -; Genomic_DNA.
DR EMBL; FN556189; CBH19535.1; -; Genomic_DNA.
DR EMBL; HF546976; CCO61942.1; -; Genomic_DNA.
DR EMBL; RXTL01000111; RTS35927.1; -; Genomic_DNA.
DR RefSeq; WP_022675713.1; NZ_WUDM01000176.1.
DR PCDDB; Q9RGC2; -.
DR SMR; Q9RGC2; -.
DR GeneID; 69562817; -.
DR KEGG; ag:AAD54217; -.
DR BRENDA; 2.7.7.47; 5087.
DR Proteomes; UP000276985; Unassembled WGS sequence.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:AAD54217.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAD54217.1}.
FT DOMAIN 28..92
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 153..255
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 281 AA; 30807 MW; BD07E4E4A29FA556 CRC64;
MSNAVPAEIS VQLSLALNAI ERHLESTLLA VHLYGSALDG GLKPYSDIDL LVTVAARLDE
TVRQALVVDL LEISASPGQS EALRALEVTI VVHGDVVPWR YPARRELQFG EWQRKDILAG
IFEPATTDVD LAILLTKVRQ HSLALAGSAA EDFFNPVPEG DLFKALSDTL KLWNSQPDWE
GDERNVVLTL SRIWYSAATG KIAPKDIVAN WAMERLPDQH KPVLLEARQA YLGQGEDCLA
SRADQLAAFV HFVKHEATKL LSAMPVMSNN SFKPTPLRGA A
//