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Database: UniProt
Entry: Q9RIL5_ECOLX
LinkDB: Q9RIL5_ECOLX
Original site: Q9RIL5_ECOLX 
ID   Q9RIL5_ECOLX            Unreviewed;       263 AA.
AC   Q9RIL5;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 112.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN   Name=aadA1 {ECO:0000313|EMBL:AAP51285.1};
GN   Synonyms=aadA2 {ECO:0000313|EMBL:AIV43456.1};
GN   ORFNames=E0I52_26240 {ECO:0000313|EMBL:TZE36467.1}, G5603_26580
GN   {ECO:0000313|EMBL:NGE91670.1}, GRW56_21815
GN   {ECO:0000313|EMBL:MXG84731.1}, GRW57_07375
GN   {ECO:0000313|EMBL:MXH40146.1};
OS   Escherichia coli.
OG   Plasmid R751 {ECO:0000313|EMBL:AAG45721.1}, and
OG   Plasmid pNDM-HU01 {ECO:0000313|EMBL:BAN37430.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:AAP51285.1};
RN   [1] {ECO:0000313|EMBL:AAG45721.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MG-1 {ECO:0000313|EMBL:AAG45721.1};
RC   PLASMID=R751 {ECO:0000313|EMBL:AAG45721.1};
RX   PubMed=10049269;
RA   Poirel L., Naas T., Guibert M., Chaibi E.B., Labia R., Nordmann P.;
RT   "Molecular and biochemical characterization of VEB-1, a novel class A
RT   extended-spectrum beta-lactamase encoded by an Escherichia coli integron
RT   gene.";
RL   Antimicrob. Agents Chemother. 43:573-581(1999).
RN   [2] {ECO:0000313|EMBL:AAG45721.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MG-1 {ECO:0000313|EMBL:AAG45721.1};
RC   PLASMID=R751 {ECO:0000313|EMBL:AAG45721.1};
RX   PubMed=11114922; DOI=10.1128/JB.183.1.235-249.2001;
RA   Naas T., Mikami Y., Imai T., Poirel L., Nordmann P.;
RT   "Characterization of In53, a class 1 plasmid- and composite transposon-
RT   located integron of Escherichia coli which carries an unusual array of gene
RT   cassettes.";
RL   J. Bacteriol. 183:235-249(2001).
RN   [3] {ECO:0000313|EMBL:AAP51285.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12821505; DOI=10.1128/AAC.47.7.2380-2381.2003;
RA   Dubois V., Arpin C., Quentin C., Texier-Maugein J., Poirel L., Nordmann P.;
RT   "Decreased susceptibility to cefepime in a clinical strain of Escherichia
RT   coli related to plasmid- and integron-encoded OXA-30 beta-lactamase.";
RL   Antimicrob. Agents Chemother. 47:2380-2381(2003).
RN   [4] {ECO:0000313|EMBL:ABX75131.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MM.1.12 {ECO:0000313|EMBL:ABX75131.1};
RX   PubMed=17913715; DOI=10.1093/jac/dkm340;
RA   Moura A., Henriques I., Ribeiro R., Correia A.;
RT   "Prevalence and characterization of integrons from bacteria isolated from a
RT   slaughterhouse wastewater treatment plant.";
RL   J. Antimicrob. Chemother. 60:1243-1250(2007).
RN   [5] {ECO:0000313|EMBL:ABY55283.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KD36 {ECO:0000313|EMBL:ABY55283.1};
RX   PubMed=19229487; DOI=10.1007/s12275-008-0206-z;
RA   Ozgumus O.B., Sandalli C., Sevim A., Celik-Sevim E., Sivri N.;
RT   "Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance
RT   in coliforms isolated from ten rivers in northern Turkey.";
RL   J. Microbiol. 47:19-27(2009).
RN   [6] {ECO:0000313|EMBL:ABQ02277.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FD8bA {ECO:0000313|EMBL:ABQ02277.1};
RA   Colakoglu F., Ozgumus O.B., Sandalli C., Celik Sevim E., Alpay Karaoglu S.;
RT   "Class 1 and class 2 integron gene cassettes and characterization of
RT   antibiotic resistance in coliforms of sea water origin.";
RL   Turk Mikrobiyol Cemiy Derg 40:97-108(2010).
RN   [7] {ECO:0000313|EMBL:CCC21000.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=23F {ECO:0000313|EMBL:CCC21000.1};
RA   Zhang S.;
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:CCC21000.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=23F {ECO:0000313|EMBL:CCC21000.1};
RA   Gu X., Han N.;
RT   "Characterization of antibiotic resistance genes in surface water and E.
RT   coli in Tai-lake basin.";
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:BAN37430.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MS5260 {ECO:0000313|EMBL:BAN37430.1};
RC   PLASMID=pNDM-HU01 {ECO:0000313|EMBL:BAN37430.1};
RA   Kayama S., Shigemoto N., Kuwahara R., Koba Y., Onodera M., Yokozaki M.,
RA   Ohge H., Kato F., Hisatsune J., Sugai M.;
RT   "The first isolation of an NDM-1-producing Escherichia coli in West
RT   Japan.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AIV43456.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=APp10510_Sm3 {ECO:0000313|EMBL:AIV43456.1};
RA   Ramos Madrigal J., Vinuesa P.;
RT   "Distribution and prevalence of antibiotic resistant Enterobacteria in two
RT   rivers sharing the same origin but contrasting degree of contamination.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AIP98308.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NF27595 {ECO:0000313|EMBL:AIP98308.1};
RA   Cheng C., Sun J., Rui Y.;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:ALD19743.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Pn28 {ECO:0000313|EMBL:ALD19743.1};
RA   Wailan A.M., Sartor A.L., Zowawi H.M., Perry J.D., Paterson D.L.,
RA   Sidjabat H.E.;
RT   "The genetic characterization of NDM-1 producing Enterobacteriaceae and
RT   Acinetobacter baumannii from Pakistan hospitals for an insight of blaNDM
RT   acquisition via plasmids.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:TZE36467.1, ECO:0000313|Proteomes:UP000322895}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=532 {ECO:0000313|EMBL:TZE36467.1,
RC   ECO:0000313|Proteomes:UP000322895};
RA   Cormier A.C., Chalmer G., Cook S.R., Zaheer R., Hannon S.J., Booker C.W.,
RA   Read R., Gow S.P., Mcallister T.A., Boerlin P.;
RT   "The presence and diversity of blaCTX-M among Escherichia coli from urban
RT   wastewater and feedlot cattle, in Alberta, Canada.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Proteomes:UP000435694, ECO:0000313|Proteomes:UP000470386}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=10434wA8 {ECO:0000313|EMBL:MXG84731.1,
RC   ECO:0000313|Proteomes:UP000470386}, and 10434wB8
RC   {ECO:0000313|EMBL:MXH40146.1, ECO:0000313|Proteomes:UP000435694};
RA   Subbiah M., Call D.;
RT   "Enteriobacteria Tanzani isolates_10434.";
RL   Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:NGE91670.1, ECO:0000313|Proteomes:UP000472856}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ECM_75 {ECO:0000313|EMBL:NGE91670.1,
RC   ECO:0000313|Proteomes:UP000472856};
RA   Tokajian S., El Chaar M., El Khoury M.;
RT   "WGS of Carbapenem-Resistant Enterobacteriaceae.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672,
CC         ECO:0000256|PIRNR:PIRNR000819};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070,
CC         ECO:0000256|PIRNR:PIRNR000819};
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DR   EMBL; AF205943; AAG45721.1; -; Genomic_DNA.
DR   EMBL; AY224185; AAP51285.1; -; Genomic_DNA.
DR   EMBL; EF543148; ABQ02277.1; -; Genomic_DNA.
DR   EMBL; EU089669; ABX75131.1; -; Genomic_DNA.
DR   EMBL; EU339234; ABY55283.1; -; Genomic_DNA.
DR   EMBL; KM111261; AIP98308.1; -; Genomic_DNA.
DR   EMBL; KF914287; AIV43456.1; -; Genomic_DNA.
DR   EMBL; KP770023; ALD19743.1; -; Genomic_DNA.
DR   EMBL; AB769140; BAN37430.1; -; Genomic_DNA.
DR   EMBL; FR875295; CCC21000.1; -; Genomic_DNA.
DR   EMBL; WUHB01000719; MXG84731.1; -; Genomic_DNA.
DR   EMBL; WUHA01000098; MXH40146.1; -; Genomic_DNA.
DR   EMBL; JAAJRI010000065; NGE91670.1; -; Genomic_DNA.
DR   EMBL; SJGG01000146; TZE36467.1; -; Genomic_DNA.
DR   PIR; B39880; B39880.
DR   RefSeq; WP_001209508.1; NZ_PQTF01000035.1.
DR   PATRIC; fig|562.7298.peg.1222; -.
DR   Proteomes; UP000322895; Unassembled WGS sequence.
DR   Proteomes; UP000435694; Unassembled WGS sequence.
DR   Proteomes; UP000470386; Unassembled WGS sequence.
DR   Proteomes; UP000472856; Unassembled WGS sequence.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW   ECO:0000256|PIRNR:PIRNR000819};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW   ECO:0000313|EMBL:AAP51285.1}; Plasmid {ECO:0000313|EMBL:AAG45721.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAP51285.1}.
FT   DOMAIN          28..76
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          152..254
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   263 AA;  29360 MW;  1E9EAC8CDA103FDF CRC64;
     MREVVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
     TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
     IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
     GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEEDRLA
     SRADQLEEFV HYVKGEITKV VGK
//
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