ID Q9RIL5_ECOLX Unreviewed; 263 AA.
AC Q9RIL5;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 112.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA1 {ECO:0000313|EMBL:AAP51285.1};
GN Synonyms=aadA2 {ECO:0000313|EMBL:AIV43456.1};
GN ORFNames=E0I52_26240 {ECO:0000313|EMBL:TZE36467.1}, G5603_26580
GN {ECO:0000313|EMBL:NGE91670.1}, GRW56_21815
GN {ECO:0000313|EMBL:MXG84731.1}, GRW57_07375
GN {ECO:0000313|EMBL:MXH40146.1};
OS Escherichia coli.
OG Plasmid R751 {ECO:0000313|EMBL:AAG45721.1}, and
OG Plasmid pNDM-HU01 {ECO:0000313|EMBL:BAN37430.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AAP51285.1};
RN [1] {ECO:0000313|EMBL:AAG45721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MG-1 {ECO:0000313|EMBL:AAG45721.1};
RC PLASMID=R751 {ECO:0000313|EMBL:AAG45721.1};
RX PubMed=10049269;
RA Poirel L., Naas T., Guibert M., Chaibi E.B., Labia R., Nordmann P.;
RT "Molecular and biochemical characterization of VEB-1, a novel class A
RT extended-spectrum beta-lactamase encoded by an Escherichia coli integron
RT gene.";
RL Antimicrob. Agents Chemother. 43:573-581(1999).
RN [2] {ECO:0000313|EMBL:AAG45721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MG-1 {ECO:0000313|EMBL:AAG45721.1};
RC PLASMID=R751 {ECO:0000313|EMBL:AAG45721.1};
RX PubMed=11114922; DOI=10.1128/JB.183.1.235-249.2001;
RA Naas T., Mikami Y., Imai T., Poirel L., Nordmann P.;
RT "Characterization of In53, a class 1 plasmid- and composite transposon-
RT located integron of Escherichia coli which carries an unusual array of gene
RT cassettes.";
RL J. Bacteriol. 183:235-249(2001).
RN [3] {ECO:0000313|EMBL:AAP51285.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12821505; DOI=10.1128/AAC.47.7.2380-2381.2003;
RA Dubois V., Arpin C., Quentin C., Texier-Maugein J., Poirel L., Nordmann P.;
RT "Decreased susceptibility to cefepime in a clinical strain of Escherichia
RT coli related to plasmid- and integron-encoded OXA-30 beta-lactamase.";
RL Antimicrob. Agents Chemother. 47:2380-2381(2003).
RN [4] {ECO:0000313|EMBL:ABX75131.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MM.1.12 {ECO:0000313|EMBL:ABX75131.1};
RX PubMed=17913715; DOI=10.1093/jac/dkm340;
RA Moura A., Henriques I., Ribeiro R., Correia A.;
RT "Prevalence and characterization of integrons from bacteria isolated from a
RT slaughterhouse wastewater treatment plant.";
RL J. Antimicrob. Chemother. 60:1243-1250(2007).
RN [5] {ECO:0000313|EMBL:ABY55283.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KD36 {ECO:0000313|EMBL:ABY55283.1};
RX PubMed=19229487; DOI=10.1007/s12275-008-0206-z;
RA Ozgumus O.B., Sandalli C., Sevim A., Celik-Sevim E., Sivri N.;
RT "Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance
RT in coliforms isolated from ten rivers in northern Turkey.";
RL J. Microbiol. 47:19-27(2009).
RN [6] {ECO:0000313|EMBL:ABQ02277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FD8bA {ECO:0000313|EMBL:ABQ02277.1};
RA Colakoglu F., Ozgumus O.B., Sandalli C., Celik Sevim E., Alpay Karaoglu S.;
RT "Class 1 and class 2 integron gene cassettes and characterization of
RT antibiotic resistance in coliforms of sea water origin.";
RL Turk Mikrobiyol Cemiy Derg 40:97-108(2010).
RN [7] {ECO:0000313|EMBL:CCC21000.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=23F {ECO:0000313|EMBL:CCC21000.1};
RA Zhang S.;
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:CCC21000.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=23F {ECO:0000313|EMBL:CCC21000.1};
RA Gu X., Han N.;
RT "Characterization of antibiotic resistance genes in surface water and E.
RT coli in Tai-lake basin.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:BAN37430.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MS5260 {ECO:0000313|EMBL:BAN37430.1};
RC PLASMID=pNDM-HU01 {ECO:0000313|EMBL:BAN37430.1};
RA Kayama S., Shigemoto N., Kuwahara R., Koba Y., Onodera M., Yokozaki M.,
RA Ohge H., Kato F., Hisatsune J., Sugai M.;
RT "The first isolation of an NDM-1-producing Escherichia coli in West
RT Japan.";
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:AIV43456.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=APp10510_Sm3 {ECO:0000313|EMBL:AIV43456.1};
RA Ramos Madrigal J., Vinuesa P.;
RT "Distribution and prevalence of antibiotic resistant Enterobacteria in two
RT rivers sharing the same origin but contrasting degree of contamination.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:AIP98308.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NF27595 {ECO:0000313|EMBL:AIP98308.1};
RA Cheng C., Sun J., Rui Y.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:ALD19743.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Pn28 {ECO:0000313|EMBL:ALD19743.1};
RA Wailan A.M., Sartor A.L., Zowawi H.M., Perry J.D., Paterson D.L.,
RA Sidjabat H.E.;
RT "The genetic characterization of NDM-1 producing Enterobacteriaceae and
RT Acinetobacter baumannii from Pakistan hospitals for an insight of blaNDM
RT acquisition via plasmids.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:TZE36467.1, ECO:0000313|Proteomes:UP000322895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=532 {ECO:0000313|EMBL:TZE36467.1,
RC ECO:0000313|Proteomes:UP000322895};
RA Cormier A.C., Chalmer G., Cook S.R., Zaheer R., Hannon S.J., Booker C.W.,
RA Read R., Gow S.P., Mcallister T.A., Boerlin P.;
RT "The presence and diversity of blaCTX-M among Escherichia coli from urban
RT wastewater and feedlot cattle, in Alberta, Canada.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|Proteomes:UP000435694, ECO:0000313|Proteomes:UP000470386}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10434wA8 {ECO:0000313|EMBL:MXG84731.1,
RC ECO:0000313|Proteomes:UP000470386}, and 10434wB8
RC {ECO:0000313|EMBL:MXH40146.1, ECO:0000313|Proteomes:UP000435694};
RA Subbiah M., Call D.;
RT "Enteriobacteria Tanzani isolates_10434.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:NGE91670.1, ECO:0000313|Proteomes:UP000472856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ECM_75 {ECO:0000313|EMBL:NGE91670.1,
RC ECO:0000313|Proteomes:UP000472856};
RA Tokajian S., El Chaar M., El Khoury M.;
RT "WGS of Carbapenem-Resistant Enterobacteriaceae.";
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; AF205943; AAG45721.1; -; Genomic_DNA.
DR EMBL; AY224185; AAP51285.1; -; Genomic_DNA.
DR EMBL; EF543148; ABQ02277.1; -; Genomic_DNA.
DR EMBL; EU089669; ABX75131.1; -; Genomic_DNA.
DR EMBL; EU339234; ABY55283.1; -; Genomic_DNA.
DR EMBL; KM111261; AIP98308.1; -; Genomic_DNA.
DR EMBL; KF914287; AIV43456.1; -; Genomic_DNA.
DR EMBL; KP770023; ALD19743.1; -; Genomic_DNA.
DR EMBL; AB769140; BAN37430.1; -; Genomic_DNA.
DR EMBL; FR875295; CCC21000.1; -; Genomic_DNA.
DR EMBL; WUHB01000719; MXG84731.1; -; Genomic_DNA.
DR EMBL; WUHA01000098; MXH40146.1; -; Genomic_DNA.
DR EMBL; JAAJRI010000065; NGE91670.1; -; Genomic_DNA.
DR EMBL; SJGG01000146; TZE36467.1; -; Genomic_DNA.
DR PIR; B39880; B39880.
DR RefSeq; WP_001209508.1; NZ_PQTF01000035.1.
DR PATRIC; fig|562.7298.peg.1222; -.
DR Proteomes; UP000322895; Unassembled WGS sequence.
DR Proteomes; UP000435694; Unassembled WGS sequence.
DR Proteomes; UP000470386; Unassembled WGS sequence.
DR Proteomes; UP000472856; Unassembled WGS sequence.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:AAP51285.1}; Plasmid {ECO:0000313|EMBL:AAG45721.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAP51285.1}.
FT DOMAIN 28..76
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 152..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29360 MW; 1E9EAC8CDA103FDF CRC64;
MREVVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEEDRLA
SRADQLEEFV HYVKGEITKV VGK
//