ID Y2345_DEIRA Reviewed; 305 AA.
AC Q9RRY7;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE RecName: Full=Uncharacterized metallophosphoesterase DR_2345;
DE Flags: Precursor;
GN OrderedLocusNames=DR_2345;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG
OS 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC
RC 15346 / NCIMB 9279 / VKM B-1422 / R1;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC Note=Binds 2 divalent metal cations. {ECO:0000250};
CC -!- PTM: Predicted to be exported by the Tat system. The position of the
CC signal peptide cleavage has not been experimentally proven.
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC {ECO:0000305}.
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DR EMBL; AE000513; AAF11890.1; -; Genomic_DNA.
DR PIR; H75285; H75285.
DR RefSeq; NP_296066.1; NC_001263.1.
DR RefSeq; WP_010888971.1; NZ_JMLF01000009.1.
DR AlphaFoldDB; Q9RRY7; -.
DR STRING; 243230.DR_2345; -.
DR PaxDb; 243230-DR_2345; -.
DR EnsemblBacteria; AAF11890; AAF11890; DR_2345.
DR GeneID; 69518595; -.
DR KEGG; dra:DR_2345; -.
DR PATRIC; fig|243230.17.peg.2578; -.
DR eggNOG; COG1408; Bacteria.
DR HOGENOM; CLU_025443_3_1_0; -.
DR InParanoid; Q9RRY7; -.
DR OrthoDB; 9780884at2; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008758; F:UDP-2,3-diacylglucosamine hydrolase activity; IBA:GO_Central.
DR GO; GO:0009245; P:lipid A biosynthetic process; IBA:GO_Central.
DR CDD; cd07385; MPP_YkuE_C; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR31302:SF0; TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN; 1.
DR PANTHER; PTHR31302; TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Hydrolase; Metal-binding; Reference proteome; Signal.
FT SIGNAL 1..40
FT /note="Tat-type signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT CHAIN 41..305
FT /note="Uncharacterized metallophosphoesterase DR_2345"
FT /id="PRO_0000172854"
FT BINDING 68
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 70
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 100
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 100
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 137
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 239
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 241
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
SQ SEQUENCE 305 AA; 32238 MW; F8F59ADE18CA0F88 CRC64;
MSVVSPDPAP VPHDPQRRAL LRWLVGGGAL AGGLGVSAVA QGYRFGVTHE QWNLVGLTRP
VRLALLTDLH YGLYIGAGSV RRWVDATLAE CPDLILLGGD LVDSHFDAAA RPQQTAALLA
ELGRLRAPLG VYAVWGNHDY GSFGRSISQS PEASRADWAA RRDALRAGLA GQGVTVLLNE
GRSLRDDLWL GGVDDLRMGE ADSVAALRGS GTRATVLLAH NPDVLLRLRS APGLVLSGHT
HGGQVRLPLL GALKVPADPR FTMGWVRGPQ GIPAYVSRGL GMSGLPVRNL CEPEITLLTL
LPPGA
//
