ID Q9RW56_DEIRA Unreviewed; 523 AA.
AC Q9RW56;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00012884};
DE EC=1.2.1.88 {ECO:0000256|ARBA:ARBA00012884};
GN OrderedLocusNames=DR_0813 {ECO:0000313|EMBL:AAF10392.1};
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG
OS 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1).
OC Bacteria; Deinococcota; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230 {ECO:0000313|EMBL:AAF10392.1, ECO:0000313|Proteomes:UP000002524};
RN [1] {ECO:0000313|EMBL:AAF10392.1, ECO:0000313|Proteomes:UP000002524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 /
RC NCIMB 9279 / R1 / VKM B-1422 {ECO:0000313|Proteomes:UP000002524};
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L., Utterback T., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-
CC glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88;
CC Evidence={ECO:0000256|ARBA:ARBA00001468};
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004786}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000513; AAF10392.1; -; Genomic_DNA.
DR PIR; C75471; C75471.
DR RefSeq; NP_294537.1; NC_001263.1.
DR RefSeq; WP_010887459.1; NZ_JMLF01000005.1.
DR AlphaFoldDB; Q9RW56; -.
DR STRING; 243230.DR_0813; -.
DR PaxDb; 243230-DR_0813; -.
DR EnsemblBacteria; AAF10392; AAF10392; DR_0813.
DR GeneID; 69517057; -.
DR KEGG; dra:DR_0813; -.
DR PATRIC; fig|243230.17.peg.993; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_0_0; -.
DR InParanoid; Q9RW56; -.
DR OrthoDB; 9762913at2; -.
DR BRENDA; 1.2.1.88; 1856.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0010133; P:proline catabolic process to glutamate; IBA:GO_Central.
DR CDD; cd07124; ALDH_PutA-P5CDH-RocA; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR005932; RocA.
DR NCBIfam; TIGR01237; D1pyr5carbox2; 1.
DR PANTHER; PTHR42862; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR42862:SF1; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002524}.
FT DOMAIN 53..519
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 523 AA; 56626 MW; C54323A499BC8B60 CRC64;
MIKVQDYRPQ PFTDFTKEEN VQAYQAALAK VRKELLGKHY PLIIDGQEVD TEGKIQSINP
CDTSEVVGTT AKATIGDAEN ALQGAWKAFE SWKKWDMDAR ARILLKAAAI LKRRRLEACA
LMSIEVGKNY AEADVEVAEA IDFLEYYARS AMKYAGFGSS ETTWFEGEEN GLMSIPLGVG
VSISPWNFPC AIFVGMAAAP IVAGNCVVVK PAEDAGLIAG FMVDILREAG LPAGVLQFLP
GVGKEVGEYL TTHAKTRFIT FTGSRAVGLH INEVAAKVQP GQKWIKRVIM ELGGKDGLIV
DETADIENAI TAATQGAFGF NGQKCSAMSR LIVVDSVYDE VVNGFVERAK ALKMGTGEEN
ANVTAVVNQM SFNKIKGYLE LAPSEGKVLL GGEATGEANG KQGYYIQPTI VGDVDRNSRL
AQEEIFGPVV AVLRAKDWQD ALDIANSTEY GLTGGVCSNS RERLEQARAE FEVGNLYFNR
KITGAIVGVQ PFGGYNMSGT DSKAGGPDYL SNFMQLKTVT ERW
//
