ID HY5_SOLLC Reviewed; 158 AA.
AC Q9SM50;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Transcription factor HY5;
DE AltName: Full=LeHY5;
DE AltName: Full=tHY5;
GN Name=HY5;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Mustilli A., Formiggini F., Bowler C.;
RT "The tomato THY5 gene encodes a protein containing a bZIP transcription
RT factor domain.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION.
RX PubMed=15178762; DOI=10.1073/pnas.0400935101;
RA Liu Y., Roof S., Ye Z., Barry C., van Tuinen A., Vrebalov J., Bowler C.,
RA Giovannoni J.;
RT "Manipulation of light signal transduction as a means of modifying fruit
RT nutritional quality in tomato.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9897-9902(2004).
CC -!- FUNCTION: Transcription factor that promotes photomorphogenesis in the
CC light and positively regulates fruit pigmentation and fruit nutritional
CC quality. Probably acts downstream of the light receptor network and
CC directly affects transcription of light-induced genes.
CC {ECO:0000269|PubMed:15178762}.
CC -!- SUBUNIT: Interacts with COP1.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- PTM: Ubiquitinated by COP1. Ubiquitination takes place in darkness and
CC leads to its subsequent degradation, thereby preventing to activate
CC photomorphogenesis signals (By similarity). {ECO:0000250}.
CC -!- MISCELLANEOUS: When it is down-regulated, plants exhibit defects in
CC light responses, including inhibited seedling photomorphogenesis, loss
CC of thylakoid organization, and reduced carotenoid accumulation.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ011914; CAB57979.1; -; mRNA.
DR RefSeq; NP_001234820.1; NM_001247891.2.
DR RefSeq; XP_019070577.1; XM_019215032.1.
DR AlphaFoldDB; Q9SM50; -.
DR SMR; Q9SM50; -.
DR STRING; 4081.Q9SM50; -.
DR PaxDb; 4081-Solyc08g061130-2-1; -.
DR EnsemblPlants; Solyc08g061130.3.1; Solyc08g061130.3.1; Solyc08g061130.3.
DR GeneID; 543733; -.
DR Gramene; Solyc08g061130.3.1; Solyc08g061130.3.1; Solyc08g061130.3.
DR KEGG; sly:543733; -.
DR eggNOG; KOG1414; Eukaryota.
DR HOGENOM; CLU_068771_1_0_1; -.
DR InParanoid; Q9SM50; -.
DR OMA; STCLPMR; -.
DR OrthoDB; 418686at2759; -.
DR PhylomeDB; Q9SM50; -.
DR Proteomes; UP000004994; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0010017; P:red or far-red light signaling pathway; IBA:GO_Central.
DR GO; GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.
DR GO; GO:0010099; P:regulation of photomorphogenesis; IBA:GO_Central.
DR GO; GO:0010218; P:response to far red light; IBA:GO_Central.
DR GO; GO:0010114; P:response to red light; IBA:GO_Central.
DR CDD; cd14704; bZIP_HY5-like; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR044280; Hac1/HY5.
DR PANTHER; PTHR46714; TRANSCRIPTIONAL ACTIVATOR HAC1; 1.
DR PANTHER; PTHR46714:SF6; TRANSCRIPTIONAL ACTIVATOR HAC1; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Phytochrome signaling pathway;
KW Reference proteome; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN 1..158
FT /note="Transcription factor HY5"
FT /id="PRO_0000076561"
FT DOMAIN 86..149
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 35..46
FT /note="Interaction with COP1"
FT /evidence="ECO:0000250"
FT REGION 88..108
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 114..142
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 158 AA; 17341 MW; DB93CE4C44DA248E CRC64;
MQEQATSSIA ASSLPSSSER SSSSALHHEL KEGMESDDEI RRVPEMGGEA TGTTSASGRD
GVSAAGQAQP SAGTQRKRGR SPADKENKRL KRLLRNRVSA QQARERKKAY LIDLEARVKE
LETKNAELEE RLSTLQNENQ MLRHILKNTT AGAQEGRK
//
