ID AL2B4_ARATH Reviewed; 538 AA.
AC Q9SU63; Q42090;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 01-MAY-2013, entry version 90.
DE RecName: Full=Aldehyde dehydrogenase family 2 member B4, mitochondrial;
DE Short=ALDH2a;
DE EC=1.2.1.3;
DE Flags: Precursor;
GN Name=ALDH2B4; Synonyms=ALDH2; OrderedLocusNames=At3g48000;
GN ORFNames=T17F15.130;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10831839; DOI=10.1016/S0378-1119(00)00152-9;
RA Li Y., Nakazono M., Tsutsumi N., Hirai A.;
RT "Molecular and cellular characterizations of a cDNA clone encoding a
RT novel isozyme of aldehyde dehydrogenase from rice.";
RL Gene 249:67-74(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=11999848; DOI=10.1023/A:1014870429630;
RA Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J.,
RA Simmons C.R., Schnable P.S.;
RT "Characterization of the aldehyde dehydrogenase gene families of Zea
RT mays and Arabidopsis.";
RL Plant Mol. Biol. 48:751-764(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M.,
RA Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B.,
RA Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P.,
RA De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P.,
RA Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V.,
RA Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S.,
RA Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G.,
RA Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B.,
RA Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G.,
RA Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J.,
RA Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D.,
RA Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D.,
RA Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W.,
RA Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J.,
RA Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P.,
RA Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S.,
RA Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V.,
RA Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C.,
RA Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E.,
RA Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y.,
RA Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis
RT thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Resource (TAIR);
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-125.
RA Philipps G., Gigot C.;
RT "The Arabidopsis thaliana transcribed genome: the GDR cDNA program.";
RL Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possesses activity on acetaldehyde and glycolaldehyde in
CC vitro.
CC -!- CATALYTIC ACTIVITY: An aldehyde + NAD(+) + H(2)O = a carboxylate +
CC NADH.
CC -!- SUBUNIT: Homotetramer (By similarity).
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix (Potential).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR EMBL; AB030820; BAA96792.1; -; mRNA.
DR EMBL; AF349447; AAM27003.1; -; mRNA.
DR EMBL; AL049658; CAB41139.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78355.1; -; Genomic_DNA.
DR EMBL; AF327426; AAG42016.1; -; mRNA.
DR EMBL; AF349522; AAK15569.1; -; mRNA.
DR EMBL; AF372911; AAK49627.1; -; mRNA.
DR EMBL; AY090443; AAL91287.1; -; mRNA.
DR EMBL; BT000752; AAN31892.1; -; mRNA.
DR EMBL; BT006371; AAP21179.1; -; mRNA.
DR EMBL; Z26417; CAA81249.1; -; mRNA.
DR IPI; IPI00548267; -.
DR PIR; T06683; T06683.
DR RefSeq; NP_190383.1; NM_114669.3.
DR UniGene; At.22890; -.
DR HSSP; P05091; 1ZUM.
DR ProteinModelPortal; Q9SU63; -.
DR SMR; Q9SU63; 54-528.
DR PaxDb; Q9SU63; -.
DR PRIDE; Q9SU63; -.
DR EnsemblPlants; AT3G48000.1; AT3G48000.1; AT3G48000.
DR GeneID; 823955; -.
DR KEGG; ath:AT3G48000; -.
DR GeneFarm; 4339; -.
DR TAIR; At3g48000; -.
DR eggNOG; COG1012; -.
DR HOGENOM; HOG000271505; -.
DR InParanoid; Q9SU63; -.
DR KO; K00128; -.
DR OMA; IERDRAY; -.
DR PhylomeDB; Q9SU63; -.
DR ProtClustDB; PLN02466; -.
DR Genevestigator; Q9SU63; -.
DR GermOnline; AT3G48000; Arabidopsis thaliana.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:TAIR.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD) activity; ISS:TAIR.
DR GO; GO:0005524; F:ATP binding; IDA:TAIR.
DR GO; GO:0046686; P:response to cadmium ion; IEP:TAIR.
DR Gene3D; 3.40.309.10; -; 1.
DR Gene3D; 3.40.605.10; -; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; Aldehyde_DH/Histidinol_DH; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Mitochondrion; NAD; Oxidoreductase;
KW Reference proteome; Transit peptide.
FT TRANSIT 1 21 Mitochondrion (Potential).
FT CHAIN 22 538 Aldehyde dehydrogenase family 2 member
FT B4, mitochondrial.
FT /FTId=PRO_0000256056.
FT NP_BIND 282 287 NAD (By similarity).
FT ACT_SITE 305 305 Proton acceptor (By similarity).
FT ACT_SITE 339 339 Nucleophile (By similarity).
FT SITE 206 206 Transition state stabilizer (By
FT similarity).
FT CONFLICT 125 125 L -> C (in Ref. 6; CAA81249).
SQ SEQUENCE 538 AA; 58589 MW; B7C054157659391C CRC64;
MAARRVSSLL SRSFSASSPL LFRSQGRNCY NGGILRRFGT SSAAAEEIIN PSVQVSHTQL
LINGNFVDSA SGKTFPTLDP RTGEVIAHVA EGDAEDINRA VKAARTAFDE GPWPKMSAYE
RSRVLLRFAD LVEKHSEELA SLETWDNGKP YQQSLTAEIP MFARLFRYYA GWADKIHGLT
IPADGNYQVH TLHEPIGVAG QIIPWNFPLL MFAWKVGPAL ACGNTIVLKT AEQTPLTAFY
AGKLFLEAGL PPGVLNIVSG FGATAGAALA SHMDVDKLAF TGSTDTGKVI LGLAANSNLK
PVTLELGGKS PFIVFEDADI DKAVELAHFA LFFNQGQCCC AGSRTFVHEK VYDEFVEKSK
ARALKRVVGD PFRKGIEQGP QIDLKQFEKV MKYIKSGIES NATLECGGDQ IGDKGYFIQP
TVFSNVKDDM LIAQDEIFGP VQSILKFSDV DEVIKRANET KYGLAAGVFT KNLDTANRVS
RALKAGTVWV NCFDVFDAAI PFGGYKMSGN GREKGIYSLN NYLQIKAVVT ALNKPAWI
//
