ID Q9SWR4_CORAV Unreviewed; 161 AA.
AC Q9SWR4;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Major allergen Cor a 1.0401 {ECO:0000313|EMBL:AAD48405.1};
GN Name=CORA1.0401 {ECO:0000313|EMBL:AAD48405.1};
OS Corylus avellana (European hazel) (Corylus maxima).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fagales; Betulaceae; Corylus.
OX NCBI_TaxID=13451 {ECO:0000313|EMBL:AAD48405.1};
RN [1] {ECO:0000313|EMBL:AAD48405.1}
RP NUCLEOTIDE SEQUENCE.
RA Luettkopf D., Scheurer S., Haustein D., Vieths S.;
RT "Cloning and immunological characterization of the major hazelnut allergen,
RT Cor a 1.0401.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAD48405.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11750653; DOI=10.1016/S0161-5890(01)00087-6;
RA Luttkopf D., Muller U., Skov P.S., Ballmer-Weber B.K., Wuthrich B.,
RA Skamstrup Hansen K., Poulsen L.K., Kastner M., Haustein D., Vieths S.;
RT "Comparison of four variants of a major allergen in hazelnut (Corylus
RT avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01.";
RL Mol. Immunol. 38:515-525(2002).
RN [3] {ECO:0007829|PDB:6GQ9}
RP STRUCTURE BY NMR.
RX PubMed=31213622; DOI=10.1038/s41598-019-44999-2;
RA Jacob T., von Loetzen C.S., Reuter A., Lacher U., Schiller D., Schobert R.,
RA Mahler V., Vieths S., Rosch P., Schweimer K., Wohrl B.M.;
RT "Identification of a natural ligand of the hazel allergen Cor a 1.";
RL Sci. Rep. 9:8714-8714(2019).
RN [4] {ECO:0007829|PDB:6Y3H}
RP STRUCTURE BY NMR OF 2-161.
RX PubMed=33603065; DOI=10.1038/s41598-021-83705-z;
RA Fuehrer S., Kamenik A.S., Zeindl R., Nothegger B., Hofer F., Reider N.,
RA Liedl K.R., Tollinger M.;
RT "Inverse relation between structural flexibility and IgE reactivity of Cor
RT a 1 hazelnut allergens.";
RL Sci. Rep. 11:4173-4173(2021).
CC -!- SIMILARITY: Belongs to the BetVI family.
CC {ECO:0000256|ARBA:ARBA00009744}.
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DR EMBL; AF136945; AAD48405.1; -; mRNA.
DR PDB; 6GQ9; NMR; -; A=1-161.
DR PDB; 6Y3H; NMR; -; A=2-161.
DR PDBsum; 6GQ9; -.
DR AlphaFoldDB; Q9SWR4; -.
DR BMRB; Q9SWR4; -.
DR SMR; Q9SWR4; -.
DR Allergome; 232; Cor a 1.
DR Allergome; 239; Cor a 1.0401.
DR GO; GO:0010427; F:abscisic acid binding; IEA:InterPro.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR CDD; cd07816; Bet_v1-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR000916; Bet_v_I/MLP.
DR InterPro; IPR024949; Bet_v_I_allergen.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR31213:SF55; CLASS-10 PATHOGENESIS-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR31213; OS03G0300400 PROTEIN-RELATED; 1.
DR Pfam; PF00407; Bet_v_1; 1.
DR PRINTS; PR00634; BETALLERGEN.
DR SUPFAM; SSF55961; Bet v1-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6GQ9, ECO:0007829|PDB:6Y3H};
KW Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821}.
FT DOMAIN 1..156
FT /note="Bet v I/Major latex protein"
FT /evidence="ECO:0000259|Pfam:PF00407"
SQ SEQUENCE 161 AA; 17581 MW; 7A11BC8EE263E08E CRC64;
MGVFCYEDEA TSVIPPARLF KSFVLDADNL IPKVAPQHFT SAENLEGNGG PGTIKKITFA
EGNEFKYMKH KVEEIDHANF KYCYSIIEGG PLGHTLEKIS YEIKMAAAPH GGGSILKITS
KYHTKGNASI NEEEIKAGKE KAAGLFKAVE AYLLAHPDAY C
//
