ID Q9TZL9_CAEEL Unreviewed; 536 AA.
AC Q9TZL9;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 140.
DE RecName: Full=Fatty acyl-CoA reductase {ECO:0000256|RuleBase:RU363097};
DE EC=1.2.1.84 {ECO:0000256|RuleBase:RU363097};
GN Name=fard-1 {ECO:0000313|EMBL:CCD71597.1,
GN ECO:0000313|WormBase:Y71H10A.2};
GN ORFNames=CELE_Y71H10A.2 {ECO:0000313|EMBL:CCD71597.1}, Y71H10A.2
GN {ECO:0000313|WormBase:Y71H10A.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD71597.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD71597.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD71597.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
CC {ECO:0000256|RuleBase:RU363097}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain
CC primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84;
CC Evidence={ECO:0000256|RuleBase:RU363097};
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928, ECO:0000256|RuleBase:RU363097}.
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DR EMBL; BX284606; CCD71597.1; -; Genomic_DNA.
DR PIR; T33480; T33480.
DR RefSeq; NP_508505.1; NM_076104.4.
DR AlphaFoldDB; Q9TZL9; -.
DR SMR; Q9TZL9; -.
DR DIP; DIP-26982N; -.
DR IntAct; Q9TZL9; 1.
DR STRING; 6239.Y71H10A.2.1; -.
DR EPD; Q9TZL9; -.
DR PaxDb; 6239-Y71H10A-2-1; -.
DR PeptideAtlas; Q9TZL9; -.
DR EnsemblMetazoa; Y71H10A.2.1; Y71H10A.2.1; WBGene00022200.
DR EnsemblMetazoa; Y71H10A.2.2; Y71H10A.2.2; WBGene00022200.
DR EnsemblMetazoa; Y71H10A.2.3; Y71H10A.2.3; WBGene00022200.
DR EnsemblMetazoa; Y71H10A.2.4; Y71H10A.2.4; WBGene00022200.
DR UCSC; Y71H10A.2.5; c. elegans.
DR AGR; WB:WBGene00022200; -.
DR WormBase; Y71H10A.2; CE20354; WBGene00022200; fard-1.
DR eggNOG; KOG1221; Eukaryota.
DR GeneTree; ENSGT00390000006367; -.
DR HOGENOM; CLU_024661_0_2_1; -.
DR InParanoid; Q9TZL9; -.
DR OMA; GMSSCVN; -.
DR OrthoDB; 1434498at2759; -.
DR PhylomeDB; Q9TZL9; -.
DR Reactome; R-CEL-9640463; Wax biosynthesis.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00022200; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0102965; F:alcohol-forming long-chain fatty acyl-CoA reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IBA:GO_Central.
DR GO; GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IBA:GO_Central.
DR CDD; cd05236; FAR-N_SDR_e; 1.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11011:SF45; FATTY ACYL-COA REDUCTASE; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF03015; Sterile; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW ECO:0000256|RuleBase:RU363097};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU363097}; NADP {ECO:0000256|RuleBase:RU363097};
KW Oxidoreductase {ECO:0000256|RuleBase:RU363097};
KW Proteomics identification {ECO:0007829|EPD:Q9TZL9,
KW ECO:0007829|PeptideAtlas:Q9TZL9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 16..286
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 358..449
FT /note="Fatty acyl-CoA reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03015"
SQ SEQUENCE 536 AA; 61246 MW; A508EE4074CD613C CRC64;
MAFSVRDVYA GSSVLLTGGT GFLGKVIVEK LLWTIDDIQN IYLMIRTRKG KNPQERLSGL
LHDPLFNRIR QEKPEAFDKL KAIGGDMMVE NLGMDPEDVM LIRDNVNVVI HSAATVKFDE
HLRAAVTMNV IGTKRIIDLC HQIKDLKVLV HVSTAYANCD RFETTEKIYK SPMAPQKLVD
ALSWMDDETL TKITPKILGL RPNTYTLTKA LAESTIETEA KDIPVIIIRP SIVGAMWQGP
LPGWTDNING PTGIFAAVGR GVLTNMCGSS ESKADIIPVD IVANMIIASA SYRTSINTTE
IPVIHCSSGE LNPLYWGHIV LFLEQFYKKY PMEQCFAVPS TYFHKSRSLF LINYYIKHHI
PAAISDISAR LIGKRKNNVK LYSKVWKMIE TLHFFTTRGW SFNARGLPEF FEKMTPADQK
EYNFDVRQVD WNSYLFDYVM GIKKFLLKEN LENLNRSRAH LLKMRIRRQV IAAIVYAGFI
STIGRKWKKT TQYLTWFGAM LATYTYTEVS FRRHIPLKSL KDYTQTSDYS RYLQKS
//
