ID Q9U1K8_DROME Unreviewed; 2160 AA.
AC Q9U1K8;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 13-SEP-2023, entry version 145.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=Pi4KIIIalpha {ECO:0000313|FlyBase:FBgn0267350};
GN Synonyms=EG:BACR7C10.2 {ECO:0000313|EMBL:CAB65858.1}, PI4KIIIalpha
GN {ECO:0000313|FlyBase:FBgn0267350};
GN ORFNames=CG10260 {ECO:0000313|FlyBase:FBgn0267350};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAB65858.1};
RN [1] {ECO:0000313|EMBL:CAB65858.1}
RP NUCLEOTIDE SEQUENCE.
RA Ferraz C., Vidal S., Brun C., Bucheton A., Demaille J.G.;
RT "Sequencing the distal X chromosome of Drosophila melanogaster.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAB65858.1}
RP NUCLEOTIDE SEQUENCE.
RA Benos P.;
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; AL121804; CAB65858.1; -; Genomic_DNA.
DR PeptideAtlas; Q9U1K8; -.
DR AGR; FB:FBgn0267350; -.
DR FlyBase; FBgn0267350; Pi4KIIIalpha.
DR VEuPathDB; VectorBase:FBgn0267350; -.
DR ExpressionAtlas; Q9U1K8; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IMP:FlyBase.
DR GO; GO:0071711; P:basement membrane organization; IMP:FlyBase.
DR GO; GO:0030010; P:establishment of cell polarity; IMP:FlyBase.
DR GO; GO:0007293; P:germarium-derived egg chamber formation; IMP:FlyBase.
DR GO; GO:0048477; P:oogenesis; IMP:FlyBase.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IMP:FlyBase.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007009; P:plasma membrane organization; IMP:FlyBase.
DR GO; GO:0008582; P:regulation of synaptic assembly at neuromuscular junction; IMP:FlyBase.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1599..1774
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1879..2144
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 154..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2160 AA; 242389 MW; 061F3383DCBDB8B3 CRC64;
MTMTASDKYT YQRTVLCLAR VLAGIQPTPW DKVHVHLATH STSHSASPPG NRLFALTLSG
GHKTDMRGRS GGGGKAVQTL FRYCPQENAA GVFCLDTRAQ DAVIALGIYF LEGGCQHEGQ
IVPYLLRLAK RSHSVGGKVQ LLLEHPAVRH SGQVSGFARG DHPESGGNAE RAGQHSQVEQ
GQQLRTAAHH PVQGHGAAAL RLGAIDGSLC QQRSTAAVPH FSARAAAHPE GRRPRRHRLE
QQCQRHCGGS FSSSERLAAT HHFRPIIPRS MSGSLAQAQN ASYDDGRQRC AGGKPSKPSL
HSYFSVPYDP RTHFFTRYGS SFNQFPNMRV CESPTKGGPR PLYRVPPFPI QHLQTIFAVS
KKLLTKDTLE HLDEQASDIF SLHQIKGYCY KSFSETLNLV LVTLLRELLQ HQVDLPTPFT
KDVQEFVKRL FLNGQTELQN KQQDQERERR EENGIAVVNK YKVNVMANAA CVDLLVWAIR
DETEADKLCG RLSQKLNLEL SHKIVMDHMP LLMVCLEGLG KLAHKFPNIA GTSISYLRDF
LVAPSPILGK LHDHAMQSLA QQKKEKELTP FKIAVQHSDS RTAVVIYGDN QKPPGSGTGR
SGHAAFESLR DAAIENLSIA LRAAHTLDQF CVPALVANVS NRLFTAEKSG SESQGECHKS
NLVSLNIIVM LGHVAVALKD TSKTTQNILQ FFIQRFCKVP SEQNALIVDQ LGCMIISQCE
THVFDEIMKM FSRVTVQSAS LAYTSDPEHR KQFHHVSDAV VNALGNIAAN IQGDAEMLEL
LGKLLELFVQ IGLDGERSYD NTPGAQKASS RAGNLGMLIP VIAVLVRRLP PIKNPRQRLH
KLFKDFWAYC VVMGFTNARL WPADWYQGVQ QIAAKSPLLI SQTAHKSDMR ELNYTLAIKS
DSVNELRSQI LVLLEHSSDN VATAINKLSF AQCTYLLSVY WLEMLRVENA DEPSLEPIMS
YLCDTALQRD KTGIWQCVKC VADQVFEKFR NVLYAHDEIR EKVLESQATL LLVYFNHIHK
PIQMVADQYL SFLVDRFPHL LWNRRVLWCM LDILQLLAYS LSLDPNEETP TLRVVSTPYT
LQLMDSLPAR ELRLKDFADR CQGIVNEAMK WAPRSTRSHL QEYPNQIPTP VLAHHSGLAL
AFDSVVSSSA QHTGTMSKRP SCVNSDTPRF VSVLCLRSKY AGEISGLLSV LSEKDKAGLA
DRLVSDVWEA CAEKSDARHR GALWRATAYL IICSEISRKL LHAVASSQLE LFTESAMETA
VECWQWVLTA RQDLELCFIQ EMVSAWQTTF EKRMGLFAWE TEVTHPLAAY EGCKLVSKPI
LIAPHLIWLQ LLSEMVDTAK YCNRDKVEMF CLLLHRCLPV LKSSKQNRQV STVGCRFKLL
QCGLSLLQGN TIPKSLSRNI LRERIYSNAL DYFCGPPTCP NQSREQLLED IMILLKFWQT
MRSEKKHLVT SEVGDYDLTN ASVSSTQMLA VRNNPETASL ISGGGLVNDY TRSMSASGNA
VGMGMGVAGG GSSSGWYNTI PHSTSTLSKR SNRSKRLQYQ KDSYDKDYMK KRNLILELLA
VELEFLITWY NPNSLPDLIV PGEEQITEWR NRPYKSTVWR DYARLAWCYN PALAVFLPQR
IKNAEIIDEE VSRLVCSDPI AVCHIPEALK YLCTTKNLLQ ESPDLVYILS WSPVTPIQAL
AYFSRQYPSH PLTAQYAVKT LSSYPAESVL PYIPQLVQAL RHDTMGYVVE FIKNISRRSQ
IVAHQLIWNM QTNMYMDEDQ QHKDPNLYEA LDQLSQSIIA SFSGAAKRFY EREFDFFGKI
TAVSGEIRSF AKGIERKNAC LAALSRIKVQ GGCYLPSNPE AMVLDIDYSS GTPMQSAAKA
PYLARFRVYR CGITELETRA MEVSNNPNSQ EDAKMTLGVE SWQAAIFKVG DDVRQDMLAL
QVITIFKNIF QQVGLDLFLF PYRVVATAPG CGVIECVPNA KSRDQLGRQT DSGLSEYFQH
QYGDESSKEF QAARANFVKS MAAYSLIGYL LQIKDRHNGN IMIDKDGHII HIDFGFMFES
SPGGNIGFEP DMKLTDEMVM IMGGKMDSPA FKWFCELCVQ AFLAVRPYQD AIVSLVSLML
DTGLPCFRGQ TINLLKQRFV ATKNNKEAAA HMLAVIRNSY QNFRTRTYDM IQYYQNQIPY
//
