ID Q9U334_CAEEL Unreviewed; 459 AA.
AC Q9U334;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 159.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=unc-59 {ECO:0000313|EMBL:CAB63329.1,
GN ECO:0000313|WormBase:W09C5.2};
GN ORFNames=CELE_W09C5.2 {ECO:0000313|EMBL:CAB63329.1}, W09C5.2
GN {ECO:0000313|WormBase:W09C5.2};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB63329.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB63329.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB63329.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- INTERACTION:
CC Q9U334; Q25AR8: unc-61; NbExp=5; IntAct=EBI-7475847, EBI-7475829;
CC -!- SUBCELLULAR LOCATION: Cleavage furrow {ECO:0000256|ARBA:ARBA00004626}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR EMBL; BX284601; CAB63329.1; -; Genomic_DNA.
DR RefSeq; NP_493388.1; NM_060987.4.
DR AlphaFoldDB; Q9U334; -.
DR SMR; Q9U334; -.
DR IntAct; Q9U334; 1.
DR MINT; Q9U334; -.
DR STRING; 6239.W09C5.2.1; -.
DR EPD; Q9U334; -.
DR PaxDb; 6239-W09C5-2; -.
DR PeptideAtlas; Q9U334; -.
DR EnsemblMetazoa; W09C5.2.1; W09C5.2.1; WBGene00006793.
DR GeneID; 173233; -.
DR KEGG; cel:CELE_W09C5.2; -.
DR UCSC; W09C5.2; c. elegans.
DR AGR; WB:WBGene00006793; -.
DR WormBase; W09C5.2; CE20165; WBGene00006793; unc-59.
DR eggNOG; KOG2655; Eukaryota.
DR GeneTree; ENSGT00940000154222; -.
DR HOGENOM; CLU_017718_1_0_1; -.
DR InParanoid; Q9U334; -.
DR OMA; PFTHLEE; -.
DR OrthoDB; 5396944at2759; -.
DR PhylomeDB; Q9U334; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00006793; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0032154; C:cleavage furrow; IDA:WormBase.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IDA:WormBase.
DR GO; GO:0031105; C:septin complex; IBA:GO_Central.
DR GO; GO:0005940; C:septin ring; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0061640; P:cytoskeleton-dependent cytokinesis; IBA:GO_Central.
DR GO; GO:0018991; P:egg-laying behavior; IMP:WormBase.
DR GO; GO:0040011; P:locomotion; IMP:WormBase.
DR GO; GO:0009791; P:post-embryonic development; IMP:WormBase.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF126; SEPTIN; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Proteomics identification {ECO:0007829|EPD:Q9U334,
KW ECO:0007829|PeptideAtlas:Q9U334};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 44..317
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 52919 MW; 6BA97A795930ACC5 CRC64;
MSSRTANSSS RNDESLRTGQ HKENPNYWGF ANFPNQVFRR AVKNGFDFTL MVVGRSGLGK
STFINTLFLA EINNLNEKES APTHPHPSTV RVEEKLVKLV ENSVSLNLTL VDTPGFGDAV
NNSKCWEPIV NYVESKFFEQ FCEETRIDRG EKIVDKCVHL CLYFIEPSGH GLKPIDIELM
KHLHGRVNIV PVISKADCLT RDELLRFKKQ IVKDAETAEI KLYKFPELED PYTDKVAIEK
LRKALPFAII GSNMLKEKDG KKIRYREYPW GTVEVENMQH NDFLTLRDMI IRTNLIDMID
VTRNVHYENF RFRQMEGLPK NEKNRDPFTH LEEERRQKEQ DLDEKRNTLE KVFTEKTSAR
KKRSDERMSA LEELEQQNKQ KIDAKRAEII RLRHEISELK NGNLTSSQTS LAMYNENNHS
QNSTLNSTTK SSPPPTSATS SSSGTMKKRM GGLGLFNRN
//
