ID Q9U370_CAEEL Unreviewed; 1076 AA.
AC Q9U370;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 142.
DE SubName: Full=BRCT domain-containing protein {ECO:0000313|EMBL:CAB54313.1};
GN Name=pis-1 {ECO:0000313|EMBL:CAB54313.1,
GN ECO:0000313|WormBase:T13F2.3b};
GN ORFNames=CELE_T13F2.3 {ECO:0000313|EMBL:CAB54313.1}, T13F2.3
GN {ECO:0000313|WormBase:T13F2.3b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAB54313.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAB54313.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAB54313.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CAB54313.1; -; Genomic_DNA.
DR PIR; T24887; T24887.
DR RefSeq; NP_501748.1; NM_069347.1.
DR AlphaFoldDB; Q9U370; -.
DR SMR; Q9U370; -.
DR IntAct; Q9U370; 1.
DR STRING; 6239.T13F2.3b.1; -.
DR EPD; Q9U370; -.
DR PaxDb; 6239-T13F2-3b; -.
DR PeptideAtlas; Q9U370; -.
DR EnsemblMetazoa; T13F2.3b.1; T13F2.3b.1; WBGene00004031.
DR GeneID; 177818; -.
DR UCSC; T13F2.3a; c. elegans.
DR AGR; WB:WBGene00004031; -.
DR WormBase; T13F2.3b; CE23980; WBGene00004031; pis-1.
DR eggNOG; KOG2043; Eukaryota.
DR GeneTree; ENSGT00940000155757; -.
DR InParanoid; Q9U370; -.
DR OMA; LEFMIKY; -.
DR OrthoDB; 2880892at2759; -.
DR Reactome; R-CEL-3108214; SUMOylation of DNA damage response and repair proteins.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004031; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; Q9U370; baseline and differential.
DR GO; GO:0044666; C:MLL3/4 complex; IDA:WormBase.
DR GO; GO:0012501; P:programmed cell death; IMP:UniProtKB.
DR CDD; cd00027; BRCT; 1.
DR CDD; cd17717; BRCT_DNA_ligase_IV_rpt2; 1.
DR CDD; cd17730; BRCT_PAXIP1_rpt4; 1.
DR CDD; cd18432; BRCT_PAXIP1_rpt6_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 4.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR23196:SF1; MEDIATOR OF DNA DAMAGE CHECKPOINT PROTEIN 1; 1.
DR PANTHER; PTHR23196; PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN; 1.
DR Pfam; PF00533; BRCT; 2.
DR Pfam; PF16589; BRCT_2; 1.
DR SMART; SM00292; BRCT; 4.
DR SUPFAM; SSF52113; BRCT domain; 3.
DR PROSITE; PS50172; BRCT; 4.
PE 1: Evidence at protein level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:Q9U370,
KW ECO:0007829|PeptideAtlas:Q9U370};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 530..607
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 622..696
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 846..911
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 932..1031
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..315
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 120542 MW; 206A94A192802843 CRC64;
MADPLSKEED IQHRPDSPPL GLLDPSRIQN PLANDQLHQV PQQQNPSGFV MPEQPRQQPP
PQTWQRTPTM SPANIFQGDS GSGTPGSQRS STGTPNHQMG NPPQHQQQQF FHGESPAHSQ
GTPMTPQSAG MPGSNCGTPQ SAGGPPTSVP YDYQQAQMQQ QQHAQAMAAA AAAQQQQQQH
LQQQQYAQNP QQMHDSPYRQ HQMMQMHQHP GHPSQYPPGY PQQQAAQWQQ QMYARQAAAQ
AQAQAQAQAQ AQAQQRAAAQ RVPVPYPPGA YPPGMPGPMT PGYPAQAPAA PRTTPGSAGP
GTGPPGTPQR PQYPQGTNPQ PQQAQFTYPP TQQMTPTGQP PGYPGMPGTP TFSSPAHQMF
RQGQPTAPPG MRQYISPQAG QQQPTPGTPH RFAPPGPSGT TSSPHFAPGA PGADLRSPSL
MSPNQQSQQH TPVLPRSLHN EMTSHGMRPI ALPSQPLPQT QGTPQPILSA SSLPPQSAGA
TQFVYRPQQP NQMNTMNQMN QMHHDVNPFP IQMNVDPELY LTGIHFHCFD SEKLFEDKLD
RKNLEFMIKY HGGDIEFEAS KFHERIHQIT HVLVDSCRNT NVMTSLEHRK RIVSIQWIID
VMERERVELP WRIAHLPPPF NENFRPYLGK LFSLSGFDSS ERAAISFMAE MMGAKITPFL
ARQNDLLIAK QPADKVTRAQ EWKVPVVNFQ WIADAYVCDE ASPQKRPNVE NPRYQLENPV
MTNVNTSPNH IEGASQEFGA MMSCWKSQTI IADQAYEKAR QNRKTLQNNT FFFPSKRLSD
QAVAPTEDEI KSSRARLDEI KTHWEEHQEK MKDTPLSKEF YRVREPQARV SAWFGEGIDD
EALTILKKKL EFLGGECVEK IRDATHVILI SGRRSLVLLE SIIRGKNIMD PEWIVDSYKQ
KMWLDTLDYF LHDKELEKEF AYNCKRSVLR ARNKPVFEDI EFHVTRFVEP NQNDLVRLIE
LGGGNVHSEK PDPKYLAKCV ETEQPFIIIS CENDARFLSY LAGSKLPIYN VDLVLFAMLR
QQIEPLPQYR IPIPIVVKTP VFRQPPPYTA PPKDQEPAAS LASEPTRAAD VLSENS
//
