ID DHSA_DICDI Reviewed; 626 AA.
AC Q9U3X4; Q54V62;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 01-MAY-2013, entry version 78.
DE RecName: Full=Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;
DE EC=1.3.5.1;
DE AltName: Full=Flavoprotein subunit of complex II;
DE Short=FP;
DE Flags: Precursor;
GN Name=sdhA; ORFNames=DDB_G0280535;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX2;
RA Lay S.P., Fisher P.R.;
RT "The flavoprotein subunit 1 of Dictyostelium succinate
RT dehydrogenase.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
RA Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
RA Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
RA Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
RA Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
RA Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
RA Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
RA Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
RA Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
RA Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
RA Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
RA Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
RA Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
RA Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
RA Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
RA Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
RA Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase
CC (SDH) that is involved in complex II of the mitochondrial electron
CC transport chain and is responsible for transferring electrons from
CC succinate to ubiquinone (coenzyme Q) (By similarity).
CC -!- CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
CC -!- COFACTOR: FAD (By similarity).
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC fumarate from succinate (eukaryal route): step 1/1.
CC -!- SUBUNIT: Component of complex II composed of four subunits: a
CC flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b
CC composed of a large and a small subunit (By similarity).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral
CC membrane protein; Matrix side (By similarity).
CC -!- SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family.
CC FRD/SDH subfamily.
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DR EMBL; AF211482; AAF21045.1; -; Genomic_DNA.
DR EMBL; AAFI02000037; EAL67069.1; -; Genomic_DNA.
DR RefSeq; XP_641069.1; XM_635977.1.
DR HSSP; P0AC41; 2ACZ.
DR ProteinModelPortal; Q9U3X4; -.
DR SMR; Q9U3X4; 33-626.
DR STRING; 44689.DDB_0214886; -.
DR PRIDE; Q9U3X4; -.
DR EnsemblProtists; DDB0214886; DDB0214886; DDB_G0280535.
DR GeneID; 8622627; -.
DR KEGG; ddi:DDB_G0280535; -.
DR dictyBase; DDB_G0280535; sdhA.
DR eggNOG; COG1053; -.
DR KO; K00234; -.
DR OMA; VGCTAID; -.
DR ProtClustDB; PTZ00139; -.
DR UniPathway; UPA00223; UER01006.
DR GO; GO:0005749; C:mitochondrial respiratory chain complex II; ISS:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:EC.
DR GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; ISS:dictyBase.
DR GO; GO:0046956; P:positive phototaxis; IMP:dictyBase.
DR GO; GO:0006099; P:tricarboxylic acid cycle; ISS:dictyBase.
DR Gene3D; 1.20.58.100; -; 1.
DR InterPro; IPR003953; FAD_bind_dom.
DR InterPro; IPR003952; FRD_SDH_FAD_BS.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR011281; Succ_DH_flav_su_fwd.
DR InterPro; IPR014006; Succ_Dhase_FrdA_Gneg.
DR PANTHER; PTHR11632:SF5; PTHR11632:SF5; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR SUPFAM; SSF46977; Succ_DH_flav_C; 1.
DR TIGRFAMs; TIGR01816; sdhA_forward; 1.
DR TIGRFAMs; TIGR01812; sdhA_frdA_Gneg; 1.
DR PROSITE; PS00504; FRD_SDH_FAD_BINDING; 1.
PE 3: Inferred from homology;
KW Complete proteome; Electron transport; FAD; Flavoprotein; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW Reference proteome; Transit peptide; Transport;
KW Tricarboxylic acid cycle.
FT TRANSIT 1 24 Mitochondrion (Potential).
FT CHAIN 25 626 Succinate dehydrogenase [ubiquinone]
FT flavoprotein subunit, mitochondrial.
FT /FTId=PRO_0000327828.
FT NP_BIND 46 51 FAD (By similarity).
FT NP_BIND 69 84 FAD (By similarity).
FT NP_BIND 434 435 FAD (By similarity).
FT ACT_SITE 318 318 Proton acceptor (By similarity).
FT BINDING 253 253 FAD (By similarity).
FT BINDING 274 274 Substrate (By similarity).
FT BINDING 286 286 Substrate (By similarity).
FT BINDING 385 385 Substrate (By similarity).
FT BINDING 418 418 FAD (By similarity).
FT BINDING 429 429 Substrate (By similarity).
FT MOD_RES 77 77 Tele-8alpha-FAD histidine (By
FT similarity).
SQ SEQUENCE 626 AA; 68516 MW; C8F27868BD063D67 CRC64;
MLSSALKLTK KVCSTKSNGL IRSFSTQTQS RDYAVVDHTY DAIVVGAGGA GLRAALGLTE
KGYKTACITK LFPTRSHTVA AQGGINAALG NADQDDWRWH AYDTVKGSDF LGDQDAIHYM
CKEAVPTVLE LEQYGVPFSR MDDGRIYQRA FGGQSKNFGK GGQATRCCAA ADRTGHALLH
TLYGQAVKHN TKFFIEYFVT DLIMENGDCR GVVAINLEDG TIHRFRSHAT VIATGGYGRA
YFSATSAHTC TGDGNAMVIR AGLPCQDLEF VQFHPTGIYG SGCLITEGAR GEGGYLLNSS
GERFMPRYAP SVADLASRDV VSRSETMEIR EGRGVGPEKD HCLLNLTHLS PEIIDERLPG
IRETAMIFAG VDVTKEPIPV IPTVHYNMGG IPTNYKGQVI TQVDGKDKLV KGLYAAGESA
CVSVHGANRL GANSLLDIVV FGRAVANEIE NTLAKDTPHK PLPPNAGEES IANIDAIRFS
NGTRSTAEIR LEMQKIMQRN AAVFRDGQVL KEGVELIDKC ARSLINDLKT TDRTMIWNTD
LIESLELQNL MTQAVLTMHS AEARKESRGA HAREDYKERD DANWMKHTLS YLDVNTGKVT
LNYRPVVSET LDQSEMETIK PFKRVY
//
