ID   Q9U4E8_ANOGA            Unreviewed;       116 AA.
AC   Q9U4E8;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   22-FEB-2023, entry version 79.
DE   SubName: Full=Toll {ECO:0000313|EMBL:AAF15576.1};
DE   Flags: Fragment;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EMBL:AAF15576.1};
RN   [1] {ECO:0000313|EMBL:AAF15576.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PEST {ECO:0000313|EMBL:AAF15576.1};
RX   PubMed=10663571; DOI=10.1007/s002510050017;
RA   Luo C., Zheng L.;
RT   "Independent evolution of Toll and related genes in insects and mammals.";
RL   Immunogenetics 51:92-98(2000).
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DR   EMBL; AF185641; AAF15576.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9U4E8; -.
DR   HOGENOM; CLU_009970_0_0_1; -.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR017241; Toll-like_receptor.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR   PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
FT   DOMAIN          1..116
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF15576.1"
FT   NON_TER         116
FT                   /evidence="ECO:0000313|EMBL:AAF15576.1"
SQ   SEQUENCE   116 AA;  13647 MW;  4F71D9C43C1FC541 CRC64;
     FVSYSHKDEA FITEHLVPTL ERDPMNFKLC WHVRDWTPGE MISSQISSSV EQSRRTIIVL
     SSSFLESLWG QLEFRTAHLQ SMAERRNRLI IIIYGDIGNI YDLEPELRAY LHTNTY
//