ID Q9U5E5_ENTDI Unreviewed; 336 AA.
AC Q9U5E5;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Cysteine synthase 1 {ECO:0000313|EMBL:BAA88219.1};
OS Entamoeba dispar.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=46681 {ECO:0000313|EMBL:BAA88219.1};
RN [1] {ECO:0000313|EMBL:BAA88219.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SAW1734R {ECO:0000313|EMBL:BAA88219.1};
RX PubMed=10717309; DOI=10.1016/S0166-6851(00)00177-8;
RA Nozaki T., Tokoro M., Imada M., Saito Y., Abe Y., Shigeta Y., Takeuchi T.;
RT "Cloning and biochemical characterization of genes encoding two isozymes of
RT cysteine synthase from Entamoeba dispar.";
RL Mol. Biochem. Parasitol. 107:129-133(2000).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR605856-50};
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DR EMBL; AB028631; BAA88219.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9U5E5; -.
DR VEuPathDB; AmoebaDB:EDI_052090; -.
DR GO; GO:0004124; F:cysteine synthase activity; IEA:InterPro.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR CDD; cd01561; CBS_like; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR005856; Cys_synth.
DR InterPro; IPR005859; CysK.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01139; cysK; 1.
DR NCBIfam; TIGR01136; cysKM; 1.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF253; CYSTEINE SYNTHASE 1; 1.
DR Pfam; PF00291; PALP; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 4: Predicted;
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR605856-50}.
FT DOMAIN 18..308
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT BINDING 88
FT /ligand="pyridoxal 5'-phosphate"
FT /ligand_id="ChEBI:CHEBI:597326"
FT /evidence="ECO:0000256|PIRSR:PIRSR605856-50"
FT BINDING 192..196
FT /ligand="pyridoxal 5'-phosphate"
FT /ligand_id="ChEBI:CHEBI:597326"
FT /evidence="ECO:0000256|PIRSR:PIRSR605856-50"
FT BINDING 280
FT /ligand="pyridoxal 5'-phosphate"
FT /ligand_id="ChEBI:CHEBI:597326"
FT /evidence="ECO:0000256|PIRSR:PIRSR605856-50"
FT MOD_RES 58
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR605856-51"
SQ SEQUENCE 336 AA; 36238 MW; 40ADD543DB111473 CRC64;
MQNITINTPR KRIYRNILET IGGTPLVELH GVTEHPTIKK NTKVLVKLEC FNPMSSVKDR
VGFNIVYQAI KDGRLKPGME IIEATSGNTG IGLCQAGAVF GYPVNIVMPS TMSIERQMIM
KAFGANLVLS DGTKGMPGAI AKYEDLIKQH PNKYFPANQF GNPDNTAAHI YTANEIWEDT
NGEVDIIVSA VGTAGTVIGV GENLKKKKQG VKVVAVEPEE SAVLSGKPKG PHGIQGIGAG
FVTDIYKKEV VDEIITIKTQ DAWKMARATV KYDGIMCGMS SGAAILAGLK EAGKAENEGK
TIVIILPDCG ERYLSTDLYK TVEEGTKQQV LDSLLL
//
