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Database: UniProt
Entry: Q9UHF4
LinkDB: Q9UHF4
Original site: Q9UHF4 
ID   I20RA_HUMAN             Reviewed;         553 AA.
AC   Q9UHF4; Q14CW2; Q6UWA9; Q96SH8;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   16-APR-2014, entry version 117.
DE   RecName: Full=Interleukin-20 receptor subunit alpha;
DE            Short=IL-20 receptor subunit alpha;
DE            Short=IL-20R-alpha;
DE            Short=IL-20RA;
DE   AltName: Full=Cytokine receptor class-II member 8;
DE   AltName: Full=Cytokine receptor family 2 member 8;
DE            Short=CRF2-8;
DE   AltName: Full=IL-20R1;
DE   AltName: Full=ZcytoR7;
DE   Flags: Precursor;
GN   Name=IL20RA; ORFNames=UNQ681/PRO1315;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ILE-259 AND
RP   PHE-382.
RA   Lok S., Kho C.-J., Jelmberg A., Adams R., Whitmore T., Farrah T.,
RA   O'Hara P.;
RT   "Homo sapiens cytokine receptor homolog.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT
RP   ILE-259.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-259.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP   ILE-259.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 30-44.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
RN   [7]
RP   SUBUNIT, LIGAND-BINDING, AND TISSUE SPECIFICITY.
RX   PubMed=11163236; DOI=10.1016/S0092-8674(01)00187-8;
RA   Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T.,
RA   Carollo S., Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H.,
RA   Jelinek L., Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J.,
RA   Prunkard D., Sexson S., Sprecher C., Waggie K., West J.,
RA   Whitmore T.E., Yao L., Kuechle M.K., Dale B.A., Chandrasekher Y.A.;
RT   "Interleukin 20: discovery, receptor identification, and role in
RT   epidermal function.";
RL   Cell 104:9-19(2001).
RN   [8]
RP   LIGAND-BINDING.
RX   PubMed=11564763;
RA   Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.;
RT   "STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor
RT   complexes of two types.";
RL   J. Immunol. 167:3545-3549(2001).
RN   [9]
RP   SUBUNIT, AND LIGAND-BINDING.
RX   PubMed=12351624; DOI=10.1074/jbc.M205114200;
RA   Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J.,
RA   Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C.,
RA   Jaspers S., Chandrasekher Y.A.;
RT   "Interleukins 19, 20, and 24 signal through two distinct receptor
RT   complexes. Differences in receptor-ligand interactions mediate unique
RT   biological functions.";
RL   J. Biol. Chem. 277:47517-47523(2002).
RN   [10]
RP   SUBUNIT, AND LIGAND-BINDING.
RX   PubMed=14580208; DOI=10.1021/bi0354583;
RA   Pletnev S., Magracheva E., Kozlov S., Tobin G., Kotenko S.V.,
RA   Wlodawer A., Zdanov A.;
RT   "Characterization of the recombinant extracellular domains of human
RT   interleukin-20 receptors and their complexes with interleukin-19 and
RT   interleukin-20.";
RL   Biochemistry 42:12617-12624(2003).
RN   [11]
RP   SUBUNIT, LIGAND-BINDING, AND TISSUE SPECIFICITY.
RX   PubMed=14764663;
RA   Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V.,
RA   Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A.,
RA   Donnelly R.P., Kotenko S.V.;
RT   "IL-26 signals through a novel receptor complex composed of IL-20
RT   receptor 1 and IL-10 receptor 2.";
RL   J. Immunol. 172:2006-2010(2004).
CC   -!- FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and
CC       IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
CC   -!- SUBUNIT: Heterodimer with IL20RB and heterodimer with IL10RB.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9UHF4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9UHF4-2; Sequence=VSP_011497, VSP_011498;
CC   -!- TISSUE SPECIFICITY: Widely expressed with highest levels in skin
CC       and testis and high levels in brain. Highly expressed in psoriatic
CC       skin.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC   -!- SIMILARITY: Contains 2 fibronectin type-III domains.
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DR   EMBL; AF184971; AAF01320.1; -; mRNA.
DR   EMBL; AY358883; AAQ89242.1; -; mRNA.
DR   EMBL; AL135902; CAC38375.1; -; Genomic_DNA.
DR   EMBL; CH471051; EAW47936.1; -; Genomic_DNA.
DR   EMBL; BC113574; AAI13575.1; -; mRNA.
DR   EMBL; BC113602; AAI13603.1; -; mRNA.
DR   RefSeq; NP_001265651.1; NM_001278722.1.
DR   RefSeq; NP_001265652.1; NM_001278723.1.
DR   RefSeq; NP_001265653.1; NM_001278724.1.
DR   RefSeq; NP_055247.3; NM_014432.3.
DR   UniGene; Hs.445868; -.
DR   PDB; 4DOH; X-ray; 2.80 A; E/R=29-245.
DR   PDBsum; 4DOH; -.
DR   ProteinModelPortal; Q9UHF4; -.
DR   SMR; Q9UHF4; 39-242.
DR   IntAct; Q9UHF4; 1.
DR   STRING; 9606.ENSP00000314976; -.
DR   PhosphoSite; Q9UHF4; -.
DR   DMDM; 145559483; -.
DR   PaxDb; Q9UHF4; -.
DR   PRIDE; Q9UHF4; -.
DR   DNASU; 53832; -.
DR   Ensembl; ENST00000316649; ENSP00000314976; ENSG00000016402. [Q9UHF4-1]
DR   Ensembl; ENST00000367748; ENSP00000356722; ENSG00000016402. [Q9UHF4-2]
DR   GeneID; 53832; -.
DR   KEGG; hsa:53832; -.
DR   UCSC; uc003qhi.3; human. [Q9UHF4-1]
DR   UCSC; uc003qhk.3; human. [Q9UHF4-2]
DR   CTD; 53832; -.
DR   GeneCards; GC06M137321; -.
DR   H-InvDB; HIX0006246; -.
DR   HGNC; HGNC:6003; IL20RA.
DR   HPA; CAB024990; -.
DR   HPA; HPA042281; -.
DR   MIM; 605620; gene.
DR   neXtProt; NX_Q9UHF4; -.
DR   PharmGKB; PA29818; -.
DR   eggNOG; NOG25594; -.
DR   HOGENOM; HOG000112987; -.
DR   HOVERGEN; HBG052065; -.
DR   InParanoid; Q9UHF4; -.
DR   KO; K05136; -.
DR   OMA; FMEEWGL; -.
DR   OrthoDB; EOG7C2R12; -.
DR   PhylomeDB; Q9UHF4; -.
DR   TreeFam; TF334107; -.
DR   SignaLink; Q9UHF4; -.
DR   GeneWiki; Interleukin_20_receptor,_alpha_subunit; -.
DR   GenomeRNAi; 53832; -.
DR   NextBio; 56162; -.
DR   PRO; PR:Q9UHF4; -.
DR   ArrayExpress; Q9UHF4; -.
DR   Bgee; Q9UHF4; -.
DR   CleanEx; HS_IL20RA; -.
DR   Genevestigator; Q9UHF4; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0045124; P:regulation of bone resorption; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; Fibronectin_type3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015713; IL-20_rcpt_alpha.
DR   InterPro; IPR015373; Interferon_alpha/beta_rcpt_bsu.
DR   PANTHER; PTHR20859:SF21; PTHR20859:SF21; 1.
DR   Pfam; PF09294; Interfer-bind; 1.
DR   Pfam; PF01108; Tissue_fac; 1.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Complete proteome;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane;
KW   Polymorphism; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     29
FT   CHAIN        30    553       Interleukin-20 receptor subunit alpha.
FT                                /FTId=PRO_0000011036.
FT   TOPO_DOM     30    250       Extracellular (Potential).
FT   TRANSMEM    251    271       Helical; (Potential).
FT   TOPO_DOM    272    553       Cytoplasmic (Potential).
FT   DOMAIN       37    135       Fibronectin type-III 1.
FT   DOMAIN      136    242       Fibronectin type-III 2.
FT   COMPBIAS    353    356       Poly-Glu.
FT   CARBOHYD     42     42       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     83     83       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD     91     91       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    182    182       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    191    191       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    200    200       N-linked (GlcNAc...) (Potential).
FT   DISULFID     87     95       By similarity.
FT   DISULFID    215    236       By similarity.
FT   VAR_SEQ       1    111       Missing (in isoform 2).
FT                                /FTId=VSP_011497.
FT   VAR_SEQ     112    135       VKAIWGTKCSKWAESGRFYPFLET -> MSYNGLHQRVFKE
FT                                LKLLTLCSISS (in isoform 2).
FT                                /FTId=VSP_011498.
FT   VARIANT     259    259       V -> I (in dbSNP:rs1555498).
FT                                /FTId=VAR_031613.
FT   VARIANT     382    382       L -> F (in dbSNP:rs1342642).
FT                                /FTId=VAR_031614.
FT   STRAND       41     48
FT   STRAND       51     57
FT   STRAND       68     75
FT   HELIX        85     87
FT   STRAND       88     96
FT   TURN         98    101
FT   STRAND      108    118
FT   HELIX       131    134
FT   STRAND      141    145
FT   STRAND      151    156
FT   HELIX       172    175
FT   STRAND      180    187
FT   TURN        188    191
FT   STRAND      192    198
FT   STRAND      200    205
FT   STRAND      213    221
FT   STRAND      223    225
FT   STRAND      233    238
SQ   SEQUENCE   553 AA;  62485 MW;  D5C2621FDC848328 CRC64;
     MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM KNVLQWTPPE
     GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE TSDYEHQYYA KVKAIWGTKC
     SKWAESGRFY PFLETQIGPP EVALTTDEKS ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK
     YNVSVLNTKS NRTWSQCVTN HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL
     KDQSSEFKAK IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF
     FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP PQEEEEVKHL
     GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE YEYDVRTTDI CAGPEEQELS
     LQEEVSTQGT LLESQAALAV LGPQTLQYSY TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV
     DWDPQTGRLC IPSLSSFDQD SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ
     FMEEWGLYVQ MEN
//
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