ID Q9UMD0_HUMAN Unreviewed; 129 AA.
AC Q9UMD0;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 97.
DE RecName: Full=Serine hydroxymethyltransferase, cytosolic {ECO:0000256|ARBA:ARBA00039530};
DE EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
DE AltName: Full=Glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00032953};
DE AltName: Full=Serine methylase {ECO:0000256|ARBA:ARBA00031137};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAB54841.1};
RN [1] {ECO:0000313|EMBL:CAB54841.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Breast {ECO:0000313|EMBL:CAB54841.1};
RX PubMed=9056951;
RA Chave K.J., Snell K., Sanders P.G.;
RT "Isolation and characterisation of human genomic sequences encoding
RT cytosolic serine hydroxymethyltransferase.";
RL Biochem. Soc. Trans. 25:53-53(1997).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
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DR EMBL; Y14488; CAB54841.1; -; mRNA.
DR AlphaFoldDB; Q9UMD0; -.
DR MaxQB; Q9UMD0; -.
DR PeptideAtlas; Q9UMD0; -.
DR UniPathway; UPA00193; -.
DR GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR001085; Ser_HO-MeTrfase.
DR InterPro; IPR039429; SHMT-like_dom.
DR PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR PANTHER; PTHR11680:SF59; SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC; 1.
DR Pfam; PF00464; SHMT; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 2: Evidence at transcript level;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..129
FT /note="Serine hydroxymethyltransferase, cytosolic"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004334309"
FT DOMAIN 64..102
FT /note="Serine hydroxymethyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF00464"
SQ SEQUENCE 129 AA; 14342 MW; 411125DE83637D88 CRC64;
MRYLLQVAQL VWLLTVDSRG IGGTLDHAGF SICMLTCRHA SFFGLCEAQT FCGLSASKSP
ALLHRYYGGT EFIDELETLC QKRALQAYKL DPQCWGVDVH PTQVLVSSIW LVQASSCASP
WADMHQEES
//