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Database: UniProt
Entry: Q9UMD0_HUMAN
LinkDB: Q9UMD0_HUMAN
Original site: Q9UMD0_HUMAN 
ID   Q9UMD0_HUMAN            Unreviewed;       129 AA.
AC   Q9UMD0;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=Serine hydroxymethyltransferase, cytosolic {ECO:0000256|ARBA:ARBA00039530};
DE            EC=2.1.2.1 {ECO:0000256|ARBA:ARBA00012256};
DE   AltName: Full=Glycine hydroxymethyltransferase {ECO:0000256|ARBA:ARBA00032953};
DE   AltName: Full=Serine methylase {ECO:0000256|ARBA:ARBA00031137};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAB54841.1};
RN   [1] {ECO:0000313|EMBL:CAB54841.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Breast {ECO:0000313|EMBL:CAB54841.1};
RX   PubMed=9056951;
RA   Chave K.J., Snell K., Sanders P.G.;
RT   "Isolation and characterisation of human genomic sequences encoding
RT   cytosolic serine hydroxymethyltransferase.";
RL   Biochem. Soc. Trans. 25:53-53(1997).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777}.
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DR   EMBL; Y14488; CAB54841.1; -; mRNA.
DR   AlphaFoldDB; Q9UMD0; -.
DR   MaxQB; Q9UMD0; -.
DR   PeptideAtlas; Q9UMD0; -.
DR   UniPathway; UPA00193; -.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR039429; SHMT-like_dom.
DR   PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11680:SF59; SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   2: Evidence at transcript level;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..129
FT                   /note="Serine hydroxymethyltransferase, cytosolic"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004334309"
FT   DOMAIN          64..102
FT                   /note="Serine hydroxymethyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00464"
SQ   SEQUENCE   129 AA;  14342 MW;  411125DE83637D88 CRC64;
     MRYLLQVAQL VWLLTVDSRG IGGTLDHAGF SICMLTCRHA SFFGLCEAQT FCGLSASKSP
     ALLHRYYGGT EFIDELETLC QKRALQAYKL DPQCWGVDVH PTQVLVSSIW LVQASSCASP
     WADMHQEES
//
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