ID   Q9UVD1_PNECA            Unreviewed;       493 AA.
AC   Q9UVD1;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Kexin-like serine endoprotease {ECO:0000313|EMBL:AAF21601.1};
DE   Flags: Fragment;
OS   Pneumocystis carinii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX   NCBI_TaxID=4754 {ECO:0000313|EMBL:AAF21601.1};
RN   [1] {ECO:0000313|EMBL:AAF21601.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Rat {ECO:0000313|EMBL:AAF21601.1};
RA   Russian D.A., Andrawis-Sorial V., Kovacs J.A.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR   EMBL; AF009222; AAF21601.1; -; mRNA.
DR   MEROPS; S08.011; -.
DR   VEuPathDB; FungiDB:T552_01616; -.
DR   VEuPathDB; FungiDB:T552_02426; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR003882; Pistil_extensin.
DR   PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR01218; PSTLEXTENSIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:AAF21601.1};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        475..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          85..219
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   REGION          216..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..322
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..338
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..413
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..463
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF21601.1"
SQ   SEQUENCE   493 AA;  54146 MW;  2D896F9D94155C0D CRC64;
     CTTKHTGTSA STPIAAGIIA LILSKRSDLT WRDVQALIVY TAVPFNLNYH EWDQLPSGRY
     YNNFFGFGKL DAYAMVQQAK TFQKLNPQTI FSTQLIQVNK KFSENNGHIT STFYIHRDYP
     THYKFKNLEY ICVSFCYKHQ YRGHLEFSIT SPANVTSQLA HRRPRDKHSG IVYWTFMSVK
     HWGEKIVGNW TIDVEDKKDQ NLDGEVFDWQ LHFFGESSES EGVPPPSYPF LSRYPTTTPP
     PDPDATSPPD PDANLPPDSN ADPQPPSEPA PPSEPESQPS SEPGSQPPSK PGPQPPSDPQ
     PPSDLKPPSK PDARPRPPSD PSSQQDPDTS LSSNPTSTSS SEPPPPSPPP PPPPPPAPAP
     APAPPRPELE PEPEPGPEPV PQPPQPQPPQ PQPEPPAXPP KPQPPPPSPP EQKPTSITSS
     TSTTSSSKTK ISTTRKASST KASSTTKTST RPSPTEGTFT GSSASHLSFF EKRHLLLQMI
     LLLFFFLFLG YSF
//