ID Q9UY29_PYRAB Unreviewed; 746 AA.
AC Q9UY29;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Hypothetical membrane protein {ECO:0000313|EMBL:CAB50583.1};
DE SubName: Full=Transport protein {ECO:0000313|EMBL:CCE71147.1};
GN OrderedLocusNames=PAB1101 {ECO:0000313|EMBL:CAB50583.1};
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844 {ECO:0000313|EMBL:CAB50583.1, ECO:0000313|Proteomes:UP000000810};
RN [1] {ECO:0000313|EMBL:CAB50583.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50583.1};
RA Genoscope;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAB50583.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50583.1};
RX PubMed=10736225; DOI=10.1006/jmbi.2000.3593;
RA Gaspin C., Cavaille J., Erauso G.;
RT "Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs:
RT lessons from the Pyrococcus genomes.";
RL J. Mol. Biol. 297:895-906(2000).
RN [3] {ECO:0000313|EMBL:CAB50583.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50583.1};
RX PubMed=11381026; DOI=10.1101/gr.GR1653R;
RA Lecompte O., Ripp R., Puzos-Barbe V., Duprat S., Heilig R., Dietrich J.,
RA Thierry J.C., Poch O.;
RT "Genome evolution at the genus level: comparison of three complete genomes
RT of hyperthermophilic archaea.";
RL Genome Res. 11:981-993(2001).
RN [4] {ECO:0000313|EMBL:CAB50583.1, ECO:0000313|Proteomes:UP000000810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay {ECO:0000313|Proteomes:UP000000810}, and Orsay
RC {ECO:0000313|EMBL:CAB50583.1};
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G., Barbe V., Flament D., Galperin M., Heilig R., Ripp R.,
RA Lecompte O., Prieur D., Poch O., Quellerou J., Thierry J.C.,
RA Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [5] {ECO:0000313|EMBL:CCE71147.1, ECO:0000313|Proteomes:UP000009139}
RP GENOME REANNOTATION.
RC STRAIN=GE5 {ECO:0000313|EMBL:CCE71147.1}, and GE5 / Orsay
RC {ECO:0000313|Proteomes:UP000009139};
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AJ248288; CAB50583.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE71147.1; -; Genomic_DNA.
DR PIR; A75018; A75018.
DR RefSeq; WP_010868797.1; NC_000868.1.
DR AlphaFoldDB; Q9UY29; -.
DR STRING; 272844.PAB1101; -.
DR GeneID; 1495976; -.
DR KEGG; pab:PAB1101; -.
DR PATRIC; fig|272844.11.peg.1793; -.
DR eggNOG; arCOG02174; Archaea.
DR HOGENOM; CLU_008861_2_0_2; -.
DR OrthoDB; 42357at2157; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00921; 2A067; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF46458; Globin-like; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 639..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 683..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 234..359
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 606..734
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 746 AA; 82274 MW; BB441CFE2AD21C36 CRC64;
MLRKIARVIV IYRHSLAVVT MFLLILSAYG ITQLRFETDL SKQLPEDLEA VKSYFTLQNE
FGGSGSALIY VKIKNNDNVV DIRDPKIIEA MYSLEQRLRE KEYVTDTFSI ADLMVQILGR
LPKNMDEVKF VLNMLPPEAR NGLISGDYSS TIIIVNLNRE KNQKALVRVY NDIEREIERT
NFPQGVEVVL TGDLGITYKI LEMLQNDMNR TMAISGIIVV LILLYFYKSP IRMLVPLVPL
IFGVVMTLGF MGLLGIPLDI ATTTVGAMII GMGIDYGVHV TNRYYEERGK GKSLEEAAEE
AIAETGKALL GAALTTIAGF LALSISILPS LKRLSVSLVM GLGLAALNAV IVTPALAILE
EEFREKVMKK KEIIAIGGGK SKISFIFSML GKAIKRSPWT ALLIALIISG VSLYGASKIT
TEVRLEKMIP TDLPEIQALS DIRSEFGGQD EVTILIKADD VRDPTLVRDI LRFEREIKAD
SYINNVFETQ SIADVVIQKY GYIPQDKEKI SEAIEGSSLV SSDYSMTIIK LKGNFMGVTQ
SEFNRIMEYF ERAIQRADFP PGVKVELAGE SYLNYVLNDL VNEELGKIST IGTLIVVMVV
FAIFRRPTVS IAMIMPMFLG ALWTIGYMGL AGIPFSQTLA GVVSMIVGLG VDYGMHITHR
FLEELNEGNK TPIITALESV GPGIFVGALT TAGGFLALLS AQLTAIHDFG RVLAVGIFAS
MFAAYLVTPA ILQLEFGRKI SKEVRE
//
