ID Q9UZE3_PYRAB Unreviewed; 151 AA.
AC Q9UZE3;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Multisubunit Na+/H+ antiporter MnhB subunit, putative {ECO:0000313|EMBL:CAB50116.1};
DE SubName: Full=Putative monovalent cation/H+ antiporter subunit B {ECO:0000313|EMBL:CCE70640.1};
GN OrderedLocusNames=PAB0804 {ECO:0000313|EMBL:CAB50116.1};
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844 {ECO:0000313|EMBL:CAB50116.1, ECO:0000313|Proteomes:UP000000810};
RN [1] {ECO:0000313|EMBL:CAB50116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50116.1};
RA Genoscope;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAB50116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50116.1};
RX PubMed=10736225; DOI=10.1006/jmbi.2000.3593;
RA Gaspin C., Cavaille J., Erauso G.;
RT "Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs:
RT lessons from the Pyrococcus genomes.";
RL J. Mol. Biol. 297:895-906(2000).
RN [3] {ECO:0000313|EMBL:CAB50116.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50116.1};
RX PubMed=11381026; DOI=10.1101/gr.GR1653R;
RA Lecompte O., Ripp R., Puzos-Barbe V., Duprat S., Heilig R., Dietrich J.,
RA Thierry J.C., Poch O.;
RT "Genome evolution at the genus level: comparison of three complete genomes
RT of hyperthermophilic archaea.";
RL Genome Res. 11:981-993(2001).
RN [4] {ECO:0000313|EMBL:CAB50116.1, ECO:0000313|Proteomes:UP000000810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay {ECO:0000313|Proteomes:UP000000810}, and Orsay
RC {ECO:0000313|EMBL:CAB50116.1};
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G., Barbe V., Flament D., Galperin M., Heilig R., Ripp R.,
RA Lecompte O., Prieur D., Poch O., Quellerou J., Thierry J.C.,
RA Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [5] {ECO:0000313|EMBL:CCE70640.1, ECO:0000313|Proteomes:UP000009139}
RP GENOME REANNOTATION.
RC STRAIN=GE5 {ECO:0000313|EMBL:CCE70640.1}, and GE5 / Orsay
RC {ECO:0000313|Proteomes:UP000009139};
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AJ248286; CAB50116.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE70640.1; -; Genomic_DNA.
DR PIR; G75101; G75101.
DR RefSeq; WP_010868323.1; NC_000868.1.
DR AlphaFoldDB; Q9UZE3; -.
DR STRING; 272844.PAB0804; -.
DR GeneID; 1496586; -.
DR KEGG; pab:PAB0804; -.
DR PATRIC; fig|272844.11.peg.1284; -.
DR eggNOG; arCOG03077; Archaea.
DR HOGENOM; CLU_1718282_0_0_2; -.
DR OrthoDB; 371891at2157; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR Pfam; PF13244; MbhD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 49..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..72
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
SQ SEQUENCE 151 AA; 16291 MW; 36DB51307AC38A1A CRC64;
MLGTMLSFMI ILLALTVVLH RDFLASLIAY SLVGLSFVML AVLARAPDVA LSAIAVGGIV
IGLFIFAYEK VREEGIELPL GLAVVPLAIA LLRLRVSVNP GSYYHYIKAW SIGNLVSEIL
AGWRLYDSVG EALILFSAAL GFSLLIRGKK K
//
