ID Q9UZH3_PYRAB Unreviewed; 352 AA.
AC Q9UZH3;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Glucose-1-phosphate thymidylyltransferase {ECO:0000313|EMBL:CCE70600.1};
DE SubName: Full=Nucleotidyltransferase {ECO:0000313|EMBL:CAB50086.1};
GN Name=graD-3 {ECO:0000313|EMBL:CAB50086.1};
GN ORFNames=PAB0784 {ECO:0000313|EMBL:CAB50086.1};
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844 {ECO:0000313|EMBL:CAB50086.1, ECO:0000313|Proteomes:UP000000810};
RN [1] {ECO:0000313|EMBL:CAB50086.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50086.1};
RA Genoscope;
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAB50086.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50086.1};
RX PubMed=10736225; DOI=10.1006/jmbi.2000.3593;
RA Gaspin C., Cavaille J., Erauso G.;
RT "Archaeal homologs of eukaryotic methylation guide small nucleolar RNAs:
RT lessons from the Pyrococcus genomes.";
RL J. Mol. Biol. 297:895-906(2000).
RN [3] {ECO:0000313|EMBL:CAB50086.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Orsay {ECO:0000313|EMBL:CAB50086.1};
RX PubMed=11381026; DOI=10.1101/gr.GR1653R;
RA Lecompte O., Ripp R., Puzos-Barbe V., Duprat S., Heilig R., Dietrich J.,
RA Thierry J.C., Poch O.;
RT "Genome evolution at the genus level: comparison of three complete genomes
RT of hyperthermophilic archaea.";
RL Genome Res. 11:981-993(2001).
RN [4] {ECO:0000313|EMBL:CAB50086.1, ECO:0000313|Proteomes:UP000000810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay {ECO:0000313|Proteomes:UP000000810}, and Orsay
RC {ECO:0000313|EMBL:CAB50086.1};
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G., Barbe V., Flament D., Galperin M., Heilig R., Ripp R.,
RA Lecompte O., Prieur D., Poch O., Quellerou J., Thierry J.C.,
RA Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [5] {ECO:0000313|EMBL:CCE70600.1, ECO:0000313|Proteomes:UP000009139}
RP GENOME REANNOTATION.
RC STRAIN=GE5 {ECO:0000313|EMBL:CCE70600.1}, and GE5 / Orsay
RC {ECO:0000313|Proteomes:UP000009139};
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
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DR EMBL; AJ248286; CAB50086.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE70600.1; -; Genomic_DNA.
DR PIR; A75098; A75098.
DR RefSeq; WP_010868292.1; NC_000868.1.
DR AlphaFoldDB; Q9UZH3; -.
DR STRING; 272844.PAB0784; -.
DR GeneID; 1496546; -.
DR KEGG; pab:PAB0784; -.
DR PATRIC; fig|272844.11.peg.1246; -.
DR eggNOG; arCOG00667; Archaea.
DR HOGENOM; CLU_029499_0_1_2; -.
DR OrthoDB; 15372at2157; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd04189; G1P_TT_long; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR005908; G1P_thy_trans_l.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR01208; rmlA_long; 1.
DR PANTHER; PTHR42883; GLUCOSE-1-PHOSPHATE THYMIDYLTRANSFERASE; 1.
DR PANTHER; PTHR42883:SF2; ZGC:136439; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Transferase {ECO:0000313|EMBL:CCE70600.1}.
FT DOMAIN 2..236
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 352 AA; 39421 MW; C9DBF7E8FBBBBBD0 CRC64;
MKALILSGGY GTRLRPLTYS QQKQLIPVAN KPVLFYAIED VIEAGIHEIG IIVGPNKEQV
IETVKSVDWD ANIEFIYQGE PKGLAHAILV ARDYLGNDDF VMYLGDNILR EGIVRHKEHF
EKSDYDASIL LCEVPNPQQF GVAELSEDGK TIKRLIEKPK HPPSNLALVG IYFFRPIIHE
AVRHIKPSWR NELEITDAIQ WLIDNGYKVG WTKVTGWWKD TGKPEDLLEA NRLVLDEIER
EIKVETRAKI IGRVKIEEGA KIDENTIIKG PAVIGRNAVI RNAYIGPYTS VGNNVVIEDT
EVEDSIIMDG SVIIGAGRII ESIIGKEVRI VRGDGHPLGR RLIVGDKSQL TL
//
