ID Q9V1Z5_PYRAB Unreviewed; 752 AA.
AC Q9V1Z5;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=ATP-dependent ERCC4-like helicase {ECO:0000313|EMBL:CAB49203.1};
GN ORFNames=PAB0190 {ECO:0000313|EMBL:CAB49203.1};
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844 {ECO:0000313|EMBL:CAB49203.1, ECO:0000313|Proteomes:UP000000810};
RN [1] {ECO:0000313|EMBL:CAB49203.1, ECO:0000313|Proteomes:UP000000810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay {ECO:0000313|Proteomes:UP000000810};
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G., Barbe V., Flament D., Galperin M., Heilig R., Ripp R.,
RA Lecompte O., Prieur D., Poch O., Quellerou J., Thierry J.C.,
RA Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
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DR EMBL; AJ248283; CAB49203.1; -; Genomic_DNA.
DR PIR; D75219; D75219.
DR AlphaFoldDB; Q9V1Z5; -.
DR IntAct; Q9V1Z5; 1.
DR MINT; Q9V1Z5; -.
DR STRING; 272844.PAB0190; -.
DR KEGG; pab:PAB0190; -.
DR PATRIC; fig|272844.11.peg.299; -.
DR eggNOG; arCOG00872; Archaea.
DR HOGENOM; CLU_002513_3_1_2; -.
DR PhylomeDB; Q9V1Z5; -.
DR Proteomes; UP000000810; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd12089; Hef_ID; 1.
DR CDD; cd18801; SF2_C_FANCM_Hef; 1.
DR CDD; cd20075; XPF_nuclease_XPF_arch; 1.
DR Gene3D; 3.40.50.10130; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.20.1320.20; hef helicase domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR006166; ERCC4_domain.
DR InterPro; IPR041755; Hef_ID.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02732; ERCC4; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF21210; RNA_helicase_helical; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00891; ERCC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CAB49203.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 20..187
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 347..514
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 752 AA; 85992 MW; 2B1839EC2CFC97B4 CRC64;
MNTMYLRKEL LQPRLYQELI YAKCKERNCL IVLPTGLGKT IIAMMIADYR LNKYGGKVLM
LAPTKPLVLQ HAETFRKFFN LPPEKIVALT GEVSPSERVK AWNRAKVIIA TPQTVENDLL
TGKINLEDVV LVIFDEAHRA VGNYAYVYIA REYLNQAKNP HVIGLTASPG SSQEKILEVL
RNLGIEHIEY RSENSPDVKP YVQGIKFEWI KVELPGLYKE VRKLLRDMLR DSLKPLAEAG
LIESASADLP KKEILRAGQI INEETAKGNH DLRKLLLFHA MALKLHHAIE LLETQGLSAL
RVYLKKLYEE AKTGSTRASK ELFLDRRMKK ALALLIQAKE LGIDHPKMEV LKELVKEQLS
KKENSKIIVF TNYRETARKV VEELTKEGIK AKRFVGQATK ENDRGMSQRE QKLILDSFAR
GEFNVLVATS VGEEGLDVPE VDLVVFYEPV PSAIRSVQRR GRTGRQKPGR VVILIAQGTR
DEAYYWSSKH KERQMRETIR MVSQAIKREK QLSLESYVKK DTEKEMEREE KEERKGEREG
VKVVVDSREL RSEVVKRLKT LGVKIEVKTL DVGDYIISDE VAIERKSAND FIQSIIDGRL
FDQVKRLKDS YPRPVVIVEG QLYGIRNVHP NAIRGAIASI VIDFGVPIIF SSNPEETANY
IFFMARREQE ERRREVRVRG EKKALTLAER QRLIVESLPH VSATLAKRLL KHFGSVERVF
TASVPELMKV EGIGEKIARE IRRVITSPYT ED
//
