ID Q9V455_DROME Unreviewed; 514 AA.
AC Q9V455;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 193.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=Kap-alpha3 {ECO:0000313|EMBL:AAF54408.1,
GN ECO:0000313|FlyBase:FBgn0027338};
GN Synonyms=0335/13 {ECO:0000313|EMBL:AAF54408.1}, alphaKap3
GN {ECO:0000313|EMBL:AAF54408.1}, Dalpha3 {ECO:0000313|EMBL:AAF54408.1},
GN dimpalpha3 {ECO:0000313|EMBL:AAF54408.1}, dKap-alpha3
GN {ECO:0000313|EMBL:AAF54408.1}, Dmel\CG9423
GN {ECO:0000313|EMBL:AAF54408.1}, Imp alpha-3
GN {ECO:0000313|EMBL:AAF54408.1}, imp alpha3
GN {ECO:0000313|EMBL:AAF54408.1}, imp-a3 {ECO:0000313|EMBL:AAF54408.1},
GN Imp-alpha3 {ECO:0000313|EMBL:AAF54408.1}, imp-alpha3
GN {ECO:0000313|EMBL:AAF54408.1}, IMPalpha3
GN {ECO:0000313|EMBL:AAF54408.1}, Impalpha3
GN {ECO:0000313|EMBL:AAF54408.1}, impalpha3
GN {ECO:0000313|EMBL:AAF54408.1}, Kap alpha3
GN {ECO:0000313|EMBL:AAF54408.1}, Kap-?3 {ECO:0000313|EMBL:AAF54408.1},
GN Kap-alpha-3 {ECO:0000313|FlyBase:FBgn0027338}, KAP-ALPHA3
GN {ECO:0000313|EMBL:AAF54408.1}, Kapalpha3
GN {ECO:0000313|EMBL:AAF54408.1}, Kpn-alpha3
GN {ECO:0000313|EMBL:AAF54408.1}, kpn-alpha3
GN {ECO:0000313|EMBL:AAF54408.1}, Kpna3 {ECO:0000313|EMBL:AAF54408.1},
GN l(3)S033513 {ECO:0000313|EMBL:AAF54408.1};
GN ORFNames=CG9423 {ECO:0000313|EMBL:AAF54408.1,
GN ECO:0000313|FlyBase:FBgn0027338}, Dmel_CG9423
GN {ECO:0000313|EMBL:AAF54408.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAD37442.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10614818; DOI=10.1515/BC.1999.161;
RA Dockendorff T.C., Tang Z., Jongens T.A.;
RT "Cloning of karyopherin-alpha3 from Drosophila through its interaction with
RT the nuclear localization sequence of germ cell-less protein.";
RL Biol. Chem. 380:1263-1272(1999).
RN [2] {ECO:0000313|EMBL:AAD37442.1}
RP NUCLEOTIDE SEQUENCE.
RA Mason D.A., Goldfarb D.S.;
RT "Drosophila melanogaster karyopherin alpha 3.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4] {ECO:0000313|EMBL:AAL39575.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000313|EMBL:AAL39575.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA Rubin G.M., Celniker S.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [6] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [7] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [8] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [9] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [10] {ECO:0000313|EMBL:AAF54408.1}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [12] {ECO:0000313|EMBL:AAF54408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [13] {ECO:0000313|EMBL:AAF54408.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [14] {ECO:0000313|EMBL:AAF54408.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [15] {ECO:0000313|EMBL:AAF54408.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [16] {ECO:0000313|EMBL:AAF54408.1}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:AAF54408.1}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AF152928; AAD37442.1; -; mRNA.
DR EMBL; AE014297; AAF54408.1; -; Genomic_DNA.
DR EMBL; AY069430; AAL39575.1; -; mRNA.
DR EMBL; AE014297; AAN13435.1; -; Genomic_DNA.
DR EMBL; AE014297; AAO41526.1; -; Genomic_DNA.
DR EMBL; AE014297; ACZ94869.1; -; Genomic_DNA.
DR RefSeq; NP_001163572.1; NM_001170101.1.
DR RefSeq; NP_731377.1; NM_169295.3.
DR RefSeq; NP_731378.1; NM_169296.3.
DR RefSeq; NP_788614.1; NM_176437.2.
DR AlphaFoldDB; Q9V455; -.
DR SMR; Q9V455; -.
DR DIP; DIP-19988N; -.
DR IntAct; Q9V455; 4.
DR MINT; Q9V455; -.
DR STRING; 7227.FBpp0081585; -.
DR PaxDb; 7227-FBpp0081584; -.
DR DNASU; 41158; -.
DR EnsemblMetazoa; FBtr0082106; FBpp0081584; FBgn0027338.
DR EnsemblMetazoa; FBtr0082107; FBpp0081585; FBgn0027338.
DR EnsemblMetazoa; FBtr0082108; FBpp0081586; FBgn0027338.
DR EnsemblMetazoa; FBtr0301189; FBpp0290407; FBgn0027338.
DR GeneID; 41158; -.
DR KEGG; dme:Dmel_CG9423; -.
DR UCSC; CG9423-RA; d. melanogaster.
DR AGR; FB:FBgn0027338; -.
DR CTD; 41158; -.
DR FlyBase; FBgn0027338; Kap-alpha3.
DR VEuPathDB; VectorBase:FBgn0027338; -.
DR eggNOG; KOG0166; Eukaryota.
DR GeneTree; ENSGT01050000244891; -.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; Q9V455; -.
DR OMA; IPRDGFN; -.
DR OrthoDB; 916229at2759; -.
DR BioGRID-ORCS; 41158; 1 hit in 3 CRISPR screens.
DR ChiTaRS; Kap-alpha3; fly.
DR GenomeRNAi; 41158; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0027338; Expressed in oviduct (Drosophila) and 29 other cell types or tissues.
DR ExpressionAtlas; Q9V455; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0017022; F:myosin binding; IPI:FlyBase.
DR GO; GO:0005112; F:Notch binding; IDA:FlyBase.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IMP:FlyBase.
DR GO; GO:0009411; P:response to UV; IDA:FlyBase.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF28; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 1: Evidence at protein level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9V455};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..55
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 152..179
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 279..317
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 56990 MW; 0F500AC4EA90683A CRC64;
MTSMEQNRLQ NFKNKGKDQD EMRRRRNEVT VELRKNKREE TILKRRNVPN LDSNTDEEEQ
LSSSIDLKKL AKAAADATKP EQQLAAVQAA RKLLSSDKNP PINDLIQSDI LPILVECLKQ
HNHTMLQFEA AWALTNIASG TSAQTNEVVA AGAVPLFLQL LNSPAPNVCE QAVWALGNII
GDGPLLRDFV IKHGVVQPLL SFIKPDIPIT FLRNVTWVIV NLCRNKDPAP PTATIHEILP
ALNVLIHHTD TNILVDTVWA ISYLTDGGND QIQMVIESGV VPKLIPLLGN SEVKVQTAAL
RAVGNIVTGS DEQTQVVLNY DALSYFPGLL SHPKEKIRKE AVWFLSNITA GNQSQVQAVI
NVGLLPKIIE NLSKGEFQTQ KEAAWAISNL TISGNREQVF TLIKEGVIPP FCDLLSCQDT
QVINVVLDGL NNMLKVADSH VEAVANCIEE CEGLAKIERL QSHENVEIYK LAYEIIDQYF
TDEGEQTNMA PTSDGAQYNF DPHADRLTMN SFNF
//
