ID Q9VEF7_DROME Unreviewed; 2448 AA.
AC Q9VEF7;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 2.
DT 24-JAN-2024, entry version 149.
DE SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:AFH06473.1};
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:AAF55467.2};
GN Name=CG14318 {ECO:0000313|EMBL:AAF55467.2};
GN Synonyms=CG7397 {ECO:0000313|EMBL:AAF55467.2}, Dmel\CG43102
GN {ECO:0000313|EMBL:AAF55467.2};
GN ORFNames=CG43102 {ECO:0000313|EMBL:AAF55467.2,
GN ECO:0000313|FlyBase:FBgn0262562}, Dmel_CG43102
GN {ECO:0000313|EMBL:AAF55467.2};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF55467.2}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [9] {ECO:0000313|EMBL:AAF55467.2, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [10] {ECO:0000313|EMBL:AAF55467.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [11] {ECO:0000313|EMBL:AAF55467.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [12] {ECO:0000313|EMBL:AAF55467.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [13] {ECO:0000313|EMBL:AAF55467.2}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:AAF55467.2}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE014297; AAF55467.2; -; Genomic_DNA.
DR EMBL; AE014297; AFH06473.1; -; Genomic_DNA.
DR RefSeq; NP_001247155.1; NM_001260226.2.
DR RefSeq; NP_650654.2; NM_142397.3.
DR IntAct; Q9VEF7; 1.
DR EnsemblMetazoa; FBtr0305009; FBpp0293546; FBgn0262562.
DR EnsemblMetazoa; FBtr0305010; FBpp0293547; FBgn0262562.
DR GeneID; 42137; -.
DR KEGG; dme:Dmel_CG43102; -.
DR UCSC; CG14318-RA; d. melanogaster.
DR AGR; FB:FBgn0262562; -.
DR FlyBase; FBgn0262562; CG43102.
DR VEuPathDB; VectorBase:FBgn0262562; -.
DR OrthoDB; 2917131at2759; -.
DR BioGRID-ORCS; 42137; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42137; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0262562; Expressed in brain and 18 other cell types or tissues.
DR ExpressionAtlas; Q9VEF7; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:FlyBase.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; ISS:FlyBase.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 1501..1689
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 89..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2374..2410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..632
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..665
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1435
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2018..2048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2066..2105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2448 AA; 268846 MW; 5E4C6A1789EE636C CRC64;
MRHSTRTVDS EAIQLEGEAI IGDQQVPHLA PLKLSSSLPT TPQLGQRVVR GRGYKKLSWN
EEQPRRQTGE RSMIARGQEA RANPPLTYQH LTHNNNNINN NNNNNNNNNN DGEEYDPIAK
YFANTQHQKL SPGIAAKSSR ILCENCCGER QQQVGSSMDR QKQQPQQPHP QQQKRQQQQH
QQHQQKQNQQ QQQQQQLPFG DYDSVSDLSS FGFVFDGEEV DSTRRVLVDA HYEDAADDDD
DVVRPPVIEI EKRQPNTSTT KTEKSTEAAT VAAAAAATSV GDASSPVLSL SSEISDESPA
ICCYTIDKKL SQQQQQQQQL QQQQQHLQHY NSCATVSYRS YRHPPPVPPK PRVCVDFSAS
DEPALKTRRL VCQQQHHHHS HPQPPANPTH FPPRIYPANS CCIPKDYQPH AFEGNFSNNI
NYNCRFGASG ECTWGSLKGP RSLCYDRHGR LTFDSEPEPE VVVAKSNGVH KSLSESRLPV
QYYAEPKVPY DPYTDLSRVT ANVINQNISD RNSSFSLPLQ HNRGCNALNQ VSAASQINNQ
LTNHIKLNNI LLPCHCNFHV DAPYEVNKEN GHTMEKRRNT LDRFQRLGFG RKSSPAAAAS
ASTSSSSPSS TSGPEKQRKT SDRSERLREL TELLRGGGGG GSSSRASSTP TPPPPPPPPV
PPPRKPRISH LERQDTGASQ TSESEAGSAH LRMPSEETTT RHSGGAGGGG GGVGLSTAAR
IFASLRPNTS LSNLEAFMLS NREKSKSPPP PAQQNHRPAA SRCVDASATA SSSASFESTA
LASRPDSRSA HKAAPFRSVS FSQIDCKSTL SALRDRLKRD KAIEAPSPSP THSREEEIAP
PDPGWVRIPL KKTELSINLN YGQEKSLDHD AIQEEDIFSN ELAASDSSGI VFPVATASSV
IAAHATMESL TDTIQSETDC LIKEDVPPPV QPVVEITPPA SSVSGSAPNL ATLMEEQLPL
EAPPDNFLQT ATTCEIPVPV YECAAQEWLE TPAQEWVEVA PEEFGIVPET IQPPIPHAAC
KISQTPSTLT TAVRSDLVPT ISVSRSSEEG DELAKIEDEP QVEVATTARN TSMDRHIREY
SQDDLDLANV DLRSSLEAIA TPRHSTDERQ RRHLDKSTKR KGMYIDNADW QAPTEAPQRG
LALDISVANL NAIKPESPEA NTPGASQMYI SSPQSSYSFE LNTPELEKGS PSWGSGGLVR
DKAQLLSNFS CHSSEEKDDA SCRSLSYLRT DSTSDNECDR AIRERERERI TSSPTPSSGD
YDYKRFSKRP LRGPYGQMLE AEMKKPNRMH FEEILEELRE TDSLHLRGSA PGVAAGGTVG
PSRNLPQYSN SMRVRKTSTF LPVPSHARAA STPSQLEHAS KGISAATAQI SVSAKNLSQA
ELDDQVHHMK RAASEAPAPK SNHSKRSQSM STERPSQHHH HHGHGHGHSH GHHHAGKRSL
DAGSGDKAAK NAPLAGGTSG SGSGGGGKAG LKPTPALLAE LLKGSSENMI SEQRKKTIAD
TRTYVVQEIY RNEQSYVESL QTVVVKYLKV LKAPEHAGMI DTRTVDEIFF MVPDILEIHE
KFLSDLKSRL DDWDVQQKVG DAFMDTFSKL EVLEVYTSFV NNCNRAKNAI RSMKHQRPSF
SKFLETTARE HKGKLTLDNL LIKPVQKFPN YELLFQRLIK HTDHDHPDTK HLQDVLKLVH
DILVHINCKE REIMENGQRE ATLRELEGVI EGITDLIAPE RQFLLFDLVS MPSGQGARKD
RGFFLFNDLL VLTSIKKRSG TIRKPNSSIC PGTVATTLDT NKYKFLTKIS LDCLEIVKSK
DENIKRIVSE IETLAEDCNK LQQITDITVT IKYPHQYLED VIRELHREVQ RQLSERQTND
TQLNMLELTV SSPNGNQKLA VVFSKTEKRT QWEESFNEAK QKLAATLERH PIPEFLTSIP
IRKTRAGLQF TCAAATLSDN RDVWVCNSDG YVGQVCIMSL HPEPNVTSCN GVCNARILCV
ASVPAYSSAA SSRNSSSEQP AGSGGQEEKD KRHTPQSYTQ QLRDYRKSIS PSFQSASASA
TATPEKKKLT PTPTPVAGGE PADAATTGGS DTQLELNLSS SDDETEAAAA SLNVAGSTGS
TLVERVPSPA PSYHGHQDSN PEEGESNQST MWIGTEDGCI HVYNSTDNIR IKKNRIKIEH
HSAVYSILYL DNRVFVSLAN GDICVYLRDG ATSWNTCSSH CLSIGTVTSP VNKLLNVNGR
LWCSIQGIIK VLDVETLTVV NQIQISSDSK PITNMTVSNN HVWISIQNSA HIKCFHSNTH
QLVTEVNLAP AVNKMLSNCD EIIRQHKAAC LRVTSLLCCK DLIWIGTSAG VLLTIPAQGY
EKGAINIVPT GIPHGHTGHV RFLTFVETTG LEGAASGAGG GRDAGSSNSD EYTKQGSIKH
SKSKSETNNT LIISGGDGYE DFRNSGANSL SEIAGREDST NHLLIWQI
//
