ID Q9VEZ2_DROME Unreviewed; 1732 AA.
AC Q9VEZ2;
DT 01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 1.
DT 27-MAR-2024, entry version 169.
DE RecName: Full=DUF4062 domain-containing protein {ECO:0000259|Pfam:PF13271};
GN Name=Dmel\CG10185 {ECO:0000313|EMBL:AAF55270.1};
GN ORFNames=CG10185 {ECO:0000313|EMBL:AAF55270.1,
GN ECO:0000313|FlyBase:FBgn0038397}, Dmel_CG10185
GN {ECO:0000313|EMBL:AAF55270.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:AAF55270.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014297; AAF55270.1; -; Genomic_DNA.
DR RefSeq; NP_650521.1; NM_142264.3.
DR AlphaFoldDB; Q9VEZ2; -.
DR IntAct; Q9VEZ2; 3.
DR STRING; 7227.FBpp0082689; -.
DR PaxDb; 7227-FBpp0082689; -.
DR EnsemblMetazoa; FBtr0083235; FBpp0082689; FBgn0038397.
DR GeneID; 41953; -.
DR KEGG; dme:Dmel_CG10185; -.
DR UCSC; CG10185-RA; d. melanogaster.
DR AGR; FB:FBgn0038397; -.
DR FlyBase; FBgn0038397; CG10185.
DR VEuPathDB; VectorBase:FBgn0038397; -.
DR eggNOG; KOG3602; Eukaryota.
DR HOGENOM; CLU_001985_0_0_1; -.
DR InParanoid; Q9VEZ2; -.
DR OMA; QQISYNY; -.
DR OrthoDB; 2910252at2759; -.
DR PhylomeDB; Q9VEZ2; -.
DR BioGRID-ORCS; 41953; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 41953; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038397; Expressed in antenna and 2 other cell types or tissues.
DR Genevisible; Q9VEZ2; DM.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19871; BETA TRANSDUCIN-RELATED PROTEIN; 1.
DR PANTHER; PTHR19871:SF14; DUF4062 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13271; DUF4062; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 26..113
FT /note="DUF4062"
FT /evidence="ECO:0000259|Pfam:PF13271"
FT REPEAT 1275..1291
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 1732 AA; 195897 MW; AE1243C65691EE2D CRC64;
MDDRTIDSIF LGSLESLPPV SSKIVRIFTS STFTDTTMER NTLMAKCYPR IKDYCREKHG
LEFQVVDMRW GVRDEATDDH MTTELCMREI KNCQRLSMGP NFIVFLGQKY GYRPIPTYIV
SSELALICEE LTSMGVDRAI LDLWYKKDSN AVPPISVLQP ISSILINFNN KRVPKLQAED
QAVWWDTLNK MQKLLRKAAA SLGASNKMSK EDVHNYFMSV TEREVINGIL NVKNTKNHCL
SYVRYINNIN LQNLKKASLF VDIINRSLDT ESAKLLSDLR DVRLPAKIEA VNAQKYTVEW
IGREGLDIET HEEYLNHFIS HFYKNVVKLV DRAMRKEDSS AQGQIVTEIL QHLHACNNSV
KIFYGREESC ERIKRYMLGD SDKPLVLFGD GGCGKTSLLS KSVSLVATEW FAHVRPINVI
RFLGTTPDSS ALTATLISIC QQISYNYMLP FENIPDDLVP LTAHFKQLLT YASPTQPLTI
YLDSVDQLTG TQDSNKVSWI PTRLPPHCKI IISCANEPAN PTVSHEYHVL CKMIDVEENF
IEVTALGEDL AMNVIKMWMK TACRDLNNYQ WRLVANAISK CSLPIFVKLV FAEICRWRSY
TRPQETHLAN TVMDSIMLLF ERVEKQHGRI LVFHALAYIT ASKSGLSESE LEDLISLDDK
VLDDVYQYHL PPTRRIPPLL WTRIRNDLPN YLSEREADGV NVMNWYHRQF RDTAKERYFK
NMNMAIYFHS MIADYYLGIW GGGVPKPFKF TEIQRHRFGL ADKEGSADRK VPIQPLVFSS
KDGLSKRYNL RKFGELPFHF VRSRRFKDLF EHVLFNYDWL HAKLSSCPLQ AVLADFEDAS
SNTDDKEAKR ELMLVSDALR LGGAILAIYP NMLAPQLVGR LLPEIGGNPN IKMLLRACDR
SGPKDCALIP VNHCLHTPGG PLKYSLEGHQ FAVFAFCLTS DMRYMVSIST HFITFDLSTS
DLTRDVNPGI EGIMQQLVLS PDNKWAAAYS NNNQTVLLNM LSSEFVVINS PFEESHGPVS
GLYLLNQNLF ITCKLRWAQF DTRGNLVDTF DVPGENKDWE ILTMEFFNPA DYNVVFWSGS
INDMRLRLDS CRGGHYSNCQ LLFSAMVMNK ARTRAYGCAN EENFEVSVFD FIEDEVTGDI
CWTLVESLPR FENDDKEMLL QLRLDQHDRM LLGTAGKGFV IWDFGSKDKD AAEECRLREG
ALYLALPHGV RNITTRIMQS NSIMVSSKLD YAVAGVRKNL YVWCLQSGQL AKVLDAHFGR
IIQLEPLTIG NWNNLVTSSI DRSVKVWNIN NIFEKVHVID RHELQIDDIS LSEVDMAVTV
TRSCVGVWET RSGRLLAKLA DSPLGAIVTH AEITPDGRYI ISSETGKFLV WNRVSEQVVF
RDDQPGIQQI TLMDYGYKVL TVSVPNINQR DILAAAAGGS ADEANRLTAI TTMRSVPEGS
IFFRFEFPIR MITGMPFRQS VITADNAYIV VVTVDKSNKD CLGVYSATNG AFVSKVLLKG
CSIKEVISLV PMPHKANQVA VISSEKGSVM DIKTKKHVRS IAKWGGSITR DGKCGLYAPT
RGGLEMLELR KGTTVKTFIP KVAEGVFSVI CIFTENDEYV AYYHSGRKTI RVFRTADTEM
IANYRLQAEL TAIKSSKDGR AIVLGTVDGC MSVLAIVDPK KEEMNEYLND LPSRDENWKA
KLAKMKARVG FKAAIRVATI SSRYAKTSKG GEDGEEELLT EITEDIVVPV AD
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