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Database: UniProt
Entry: Q9VHC4_DROME
LinkDB: Q9VHC4_DROME
Original site: Q9VHC4_DROME 
ID   Q9VHC4_DROME            Unreviewed;      1133 AA.
AC   Q9VHC4; Q8INN8;
DT   01-MAY-2000, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 3.
DT   20-DEC-2017, entry version 127.
DE   SubName: Full=CG8176, isoform A {ECO:0000313|EMBL:AAN13430.1};
DE   SubName: Full=CG8176, isoform E {ECO:0000313|EMBL:AAF54392.3};
GN   Name=FCHo {ECO:0000313|EMBL:AAF54392.3};
GN   Synonyms=CG31123 {ECO:0000313|EMBL:AAF54392.3}, Dmel\CG8176
GN   {ECO:0000313|EMBL:AAF54392.3}, FCHo2 {ECO:0000313|EMBL:AAF54392.3};
GN   ORFNames=CG8176 {ECO:0000313|EMBL:AAF54392.3,
GN   ECO:0000313|FlyBase:FBgn0037702}, Dmel_CG8176
GN   {ECO:0000313|EMBL:AAF54392.3};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAF54392.3}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:AAF54392.3}
RP   NUCLEOTIDE SEQUENCE.
RA   Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA   Svirskas R., Rubin G.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [10] {ECO:0000313|EMBL:AAF54392.3, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [11] {ECO:0000313|EMBL:AAF54392.3}
RP   NUCLEOTIDE SEQUENCE.
RG   FlyBase;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AE014297; AAF54392.3; -; Genomic_DNA.
DR   EMBL; AE014297; AAN13430.1; -; Genomic_DNA.
DR   RefSeq; NP_788612.1; NM_176435.3.
DR   RefSeq; NP_788613.2; NM_176436.2.
DR   UniGene; Dm.26190; -.
DR   SMR; Q9VHC4; -.
DR   EnsemblMetazoa; FBtr0082065; FBpp0081543; FBgn0037702.
DR   EnsemblMetazoa; FBtr0334650; FBpp0306712; FBgn0037702.
DR   GeneID; 261329; -.
DR   UCSC; CG8176-RA; d. melanogaster.
DR   UCSC; CG8176-RB; d. melanogaster.
DR   FlyBase; FBgn0037702; CG8176.
DR   eggNOG; KOG2398; Eukaryota.
DR   eggNOG; ENOG410Y7RY; LUCA.
DR   GeneTree; ENSGT00510000046419; -.
DR   OrthoDB; EOG091G0AB1; -.
DR   Reactome; R-DME-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-DME-8856828; Clathrin-mediated endocytosis.
DR   ChiTaRS; CG8176; fly.
DR   GenomeRNAi; 261329; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0037702; -.
DR   ExpressionAtlas; Q9VHC4; differential.
DR   GO; GO:0005905; C:clathrin-coated pit; ISS:FlyBase.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; ISS:FlyBase.
DR   GO; GO:0035612; F:AP-2 adaptor complex binding; ISS:FlyBase.
DR   GO; GO:0005543; F:phospholipid binding; ISM:FlyBase.
DR   GO; GO:0072583; P:clathrin-dependent endocytosis; ISS:FlyBase.
DR   Gene3D; 1.20.1270.60; -; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; SSF103657; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077,
KW   ECO:0000256|SAAS:SAAS00803874, ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q9VHC4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN        3    247       F-BAR. {ECO:0000259|PROSITE:PS51741}.
FT   DOMAIN      839   1107       MHD. {ECO:0000259|PROSITE:PS51072}.
FT   COILED      133    187       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1133 AA;  121019 MW;  AA2FFF87BB1EAC0A CRC64;
     MTVDFNDYFW GEKNNGYDVL YHNMKFGLIA SKELSEFLRE KSNIEEQNSK MMSKLAHKAG
     TLNSTFAPVW TILRTSAEKL STLHLQMVQK LTELVKDVAK YADELHKKHK SVKEEESQTL
     ECVQAIQTST VAVQKLRDLY ASKVQELEKL RKDNGSHKDA EKLESKLKKL QEEYKALLDK
     HNPIKNEFER RMTQTCKRFQ EIEEVHLRQM KEFLSTYLEM LQNNHDMVGQ VHSDFKRQFV
     DMSVDKLLEQ FVLNKYTGLE KPEMPELEYV ALSSGSRLQQ PQVSASASNS NSATSIQAAL
     RAGNAATTAS GSAVSMDQRG DALAAISLGS GSAASGSIPF AEDPILGAMG SPRPTSPDML
     AGANASGIQS QPTGGATSTV KSLRSWFLPT AKQQPSAGAG NFGMAGSGST NNTTTTTTAS
     NNSNNLNTNN TTATTTTTTG TNNLTTNITK NSPNSEDTSN QVSGILRSRR DKTKTKKAKK
     KKDNEAAENI QEERLTSLDR GNNTLLDYDD HGRSMKTQNS SGSSAGGGLA ALSVTSAQGS
     VDSAGASSMG GSGGAAVASG SLPNAGALTN SASITAPGAA SGTGTGYEVD EEGFSIQPAK
     EIAWEEGQDK SGSFYSDSDT DSDNDKQERR IHVSIKPLKN GQAPMSASVD ELRATVENIS
     LSPTGVFSHH SQQLQAARGA PASRQQSPEI SNASTPTASV HPYAPLQSPT LSNNNNANNT
     TNSRYADLGD IFSELGDMSM SAPSSATLGK PPGRQIPTPT SASTGGSIAI PRPPSRRSDM
     IAIGPAATGT APGRGRMSPA PVTAMNRAES IGSLEFRTAI GGVGSSRGPS PLTIGISDTI
     PLAVAFHEII HAYFRGSDES RCQVKVSGDM MLSFPAGIAG LLANNPNPAK LGFRIKHVQN
     LENLVPNGKL VQIDRQQSSS VSTMLEFNMG ALTALLRRQA ENNPTASYFN VDILKYQVRT
     KPGASSCPFQ LVSYWKCESS YTALKVDYKY NNHAMASASP LLNVTLSVPV NGSVRNVQSK
     PHSAWLGESN RLVWNFTDIS QNSQDGGVGT LRARLELNDG PSTPALLATQ FNCEGTTLSG
     IEFELQGSGY RLSLVKRRFV SGKYVCEGDG IRSGATPTPP SVGSTSPYSA KSN
//
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