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Database: UniProt
Entry: Q9VV73
LinkDB: Q9VV73
Original site: Q9VV73 
ID   NXF2_DROME              Reviewed;         841 AA.
AC   Q9VV73; Q0E8E0;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   29-OCT-2014, entry version 109.
DE   RecName: Full=Nuclear RNA export factor 2;
GN   Name=nxf2; ORFNames=CG4118;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=11780633;
RA   Herold A., Klymenko T., Izaurralde E.;
RT   "NXF1/p15 heterodimers are essential for mRNA nuclear export in
RT   Drosophila.";
RL   RNA 7:1768-1780(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA   Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA   Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA   Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA   George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA   Rubin G.M., Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- FUNCTION: May be involved in the export of mRNA from the nucleus
CC       to the cytoplasm. {ECO:0000269|PubMed:11780633}.
CC   -!- SUBUNIT: Interacts with Nxt1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-
CC       ProRule:PRU00611, ECO:0000269|PubMed:11780633}. Nucleus,
CC       nucleoplasm {ECO:0000269|PubMed:11780633}. Note=Localized in both
CC       the nucleoplasm and the cytoplasm. Not detected at the nuclear
CC       rim.
CC   -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC       {ECO:0000269|PubMed:11780633}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout embryonic development.
CC       {ECO:0000269|PubMed:11780633}.
CC   -!- DOMAIN: The RNA-binding domain is a non-canonical RNP-type domain.
CC   -!- SIMILARITY: Belongs to the NXF family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 6 LRR (leucine-rich) repeats. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 NTF2 domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00137}.
CC   -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 TAP-C domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00611}.
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DR   EMBL; AJ312282; CAC41644.1; -; mRNA.
DR   EMBL; AE014296; AAF49448.3; -; Genomic_DNA.
DR   EMBL; AY075582; AAL68387.1; -; mRNA.
DR   RefSeq; NP_524111.3; NM_079387.6.
DR   RefSeq; NP_730179.2; NM_168674.4.
DR   UniGene; Dm.2730; -.
DR   ProteinModelPortal; Q9VV73; -.
DR   SMR; Q9VV73; 222-262, 357-564.
DR   BioGrid; 65146; 13.
DR   PaxDb; Q9VV73; -.
DR   PRIDE; Q9VV73; -.
DR   EnsemblMetazoa; FBtr0089478; FBpp0088483; FBgn0036640.
DR   EnsemblMetazoa; FBtr0089479; FBpp0088484; FBgn0036640.
DR   GeneID; 39843; -.
DR   KEGG; dme:Dmel_CG4118; -.
DR   CTD; 56001; -.
DR   FlyBase; FBgn0036640; nxf2.
DR   eggNOG; NOG327555; -.
DR   GeneTree; ENSGT00390000007539; -.
DR   InParanoid; Q9VV73; -.
DR   OMA; CLEESSW; -.
DR   OrthoDB; EOG77M8N1; -.
DR   PhylomeDB; Q9VV73; -.
DR   GenomeRNAi; 39843; -.
DR   NextBio; 815678; -.
DR   Bgee; Q9VV73; -.
DR   ExpressionAtlas; Q9VV73; differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005654; C:nucleoplasm; IDA:FlyBase.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   InterPro; IPR005637; TAP_C_dom.
DR   InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR   InterPro; IPR009060; UBA-like.
DR   Pfam; PF03943; TAP_C; 1.
DR   SMART; SM00446; LRRcap; 1.
DR   SMART; SM00804; TAP_C; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   PROSITE; PS51450; LRR; 5.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
DR   PROSITE; PS51281; TAP_C; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Leucine-rich repeat; mRNA transport;
KW   Nucleus; Reference proteome; Repeat; RNA-binding; Transport.
FT   CHAIN         1    841       Nuclear RNA export factor 2.
FT                                /FTId=PRO_0000220539.
FT   REPEAT      200    221       LRR 1.
FT   REPEAT      224    245       LRR 2.
FT   REPEAT      249    270       LRR 3.
FT   DOMAIN      325    408       RRM.
FT   REPEAT      475    496       LRR 4.
FT   REPEAT      500    521       LRR 5.
FT   REPEAT      524    545       LRR 6.
FT   DOMAIN      585    758       NTF2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00137}.
FT   DOMAIN      788    841       TAP-C. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00611}.
SQ   SEQUENCE   841 AA;  96635 MW;  581CE6B0C57FF098 CRC64;
     MPNQMRVLDF GDGSVPIQLD YPDSKIFSKC SSYGDRVPGT HWNEITVHHK GRLEYSPNPE
     QIILDALYQA IDGADFFPVF YQRGKNMDTM LVRNCKAAID KLFKQRLSIN LKGGASIPIS
     IQLGVAQYQR HQITPTFHIA RVVTRLMKQL IQRDGVDGLL NLDNFGSHPE FKNLVVSLGN
     PSILMNVCQV IHNDDNERFR LNGFILSNNR IRDIRPLTLL ANVDYALLDL RGNKIKSAER
     LCRALEQFRA RELLLENNPI VKISNFPANI KSLESNFELV DGKPFNMLHK IFSPLDVEID
     LEVDGARIDT NNMWKLPEFE NSQHWHAFMI PDPSHEFNQE VFFDFFFIRL DPTLSNFYPC
     YYKYINTEHV FLVRNCFDQI AHLVNNCNLE MTIPTGDRIF RYYLRMNVST VKQHHVDPEE
     CIQKAVSQCY VAQNRMLNLE RFHSRECLKD VMVSLSSPKI LTYVLSVASR KFMTTCSEIR
     LCHNKVLVLD GAHVLGMMGC LRAVDLSHNW VQDLSSIHSL GNLPLKSLVL HGNKLCRNYR
     LPSEYVRAVK EVFPQLTTLD GVDLQTNPGQ SLQKNFLCDT GAYELVGAFL ENYLREFEND
     EFRHNLYKYY SENSIFTLTC NYNVVQNHQT PKILQRLSKY NRHARNLRNK DYSKASDGVF
     FGCTYIVEIL LQLPRVTHDF HSLQTDVMHY NGKGAVIYVA GLLRDEPPST RNGHGSKTDI
     GGVLLGFSRQ FVVTFDEANL GLGKRARRLK IANERLHITN PSKTAIRNAF SVNFPDPSER
     QAEEDSLDVK DHKLLLFQEV TGLISTWVTS IVEEADWDFE RALKLFIQKN ADHEIPDLAF
     A
//
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