ID NXF2_DROME Reviewed; 841 AA.
AC Q9VV73; Q0E8E0;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 01-MAY-2013, entry version 100.
DE RecName: Full=Nuclear RNA export factor 2;
GN Name=nxf2; ORFNames=CG4118;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=11780633;
RA Herold A., Klymenko T., Izaurralde E.;
RT "NXF1/p15 heterodimers are essential for mRNA nuclear export in
RT Drosophila.";
RL RNA 7:1768-1780(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
RA Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
RA Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
RA Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
RA Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
RA Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a
RT systematic review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
RA George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
RA Rubin G.M., Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: May be involved in the export of mRNA from the nucleus
CC to the cytoplasm.
CC -!- SUBUNIT: Interacts with Nxt1 (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm.
CC Note=Localized in both the nucleoplasm and the cytoplasm. Not
CC detected at the nuclear rim.
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously.
CC -!- DEVELOPMENTAL STAGE: Expressed throughout embryonic development.
CC -!- DOMAIN: The RNA-binding domain is a non-canonical RNP-type domain.
CC -!- SIMILARITY: Belongs to the NXF family.
CC -!- SIMILARITY: Contains 6 LRR (leucine-rich) repeats.
CC -!- SIMILARITY: Contains 1 NTF2 domain.
CC -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
CC -!- SIMILARITY: Contains 1 TAP-C domain.
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DR EMBL; AJ312282; CAC41644.1; -; mRNA.
DR EMBL; AE014296; AAF49448.3; -; Genomic_DNA.
DR EMBL; AY075582; AAL68387.1; -; mRNA.
DR RefSeq; NP_524111.3; NM_079387.6.
DR RefSeq; NP_730179.2; NM_168674.4.
DR UniGene; Dm.2730; -.
DR ProteinModelPortal; Q9VV73; -.
DR SMR; Q9VV73; 204-235, 357-564.
DR PaxDb; Q9VV73; -.
DR PRIDE; Q9VV73; -.
DR EnsemblMetazoa; FBtr0089478; FBpp0088483; FBgn0036640.
DR EnsemblMetazoa; FBtr0089479; FBpp0088484; FBgn0036640.
DR GeneID; 39843; -.
DR KEGG; dme:Dmel_CG4118; -.
DR CTD; 56001; -.
DR FlyBase; FBgn0036640; nxf2.
DR eggNOG; NOG327555; -.
DR GeneTree; ENSGT00390000007539; -.
DR InParanoid; Q9VV73; -.
DR OMA; CLEESSW; -.
DR OrthoDB; EOG4J0ZQR; -.
DR PhylomeDB; Q9VV73; -.
DR GenomeRNAi; 39843; -.
DR NextBio; 815678; -.
DR Bgee; Q9VV73; -.
DR GermOnline; CG4118; Drosophila melanogaster.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005654; C:nucleoplasm; IDA:FlyBase.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR InterPro; IPR005637; TAP_C_dom.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR InterPro; IPR009060; UBA-like.
DR Pfam; PF03943; TAP_C; 1.
DR SMART; SM00446; LRRcap; 1.
DR SMART; SM00804; TAP_C; 1.
DR SUPFAM; SSF46934; UBA_like; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
DR PROSITE; PS50102; RRM; FALSE_NEG.
DR PROSITE; PS51281; TAP_C; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytoplasm; Leucine-rich repeat; mRNA transport;
KW Nucleus; Reference proteome; Repeat; RNA-binding; Transport.
FT CHAIN 1 841 Nuclear RNA export factor 2.
FT /FTId=PRO_0000220539.
FT REPEAT 200 221 LRR 1.
FT REPEAT 224 245 LRR 2.
FT REPEAT 249 270 LRR 3.
FT DOMAIN 325 408 RRM.
FT REPEAT 475 496 LRR 4.
FT REPEAT 500 521 LRR 5.
FT REPEAT 524 545 LRR 6.
FT DOMAIN 585 758 NTF2.
FT DOMAIN 788 841 TAP-C.
SQ SEQUENCE 841 AA; 96635 MW; 581CE6B0C57FF098 CRC64;
MPNQMRVLDF GDGSVPIQLD YPDSKIFSKC SSYGDRVPGT HWNEITVHHK GRLEYSPNPE
QIILDALYQA IDGADFFPVF YQRGKNMDTM LVRNCKAAID KLFKQRLSIN LKGGASIPIS
IQLGVAQYQR HQITPTFHIA RVVTRLMKQL IQRDGVDGLL NLDNFGSHPE FKNLVVSLGN
PSILMNVCQV IHNDDNERFR LNGFILSNNR IRDIRPLTLL ANVDYALLDL RGNKIKSAER
LCRALEQFRA RELLLENNPI VKISNFPANI KSLESNFELV DGKPFNMLHK IFSPLDVEID
LEVDGARIDT NNMWKLPEFE NSQHWHAFMI PDPSHEFNQE VFFDFFFIRL DPTLSNFYPC
YYKYINTEHV FLVRNCFDQI AHLVNNCNLE MTIPTGDRIF RYYLRMNVST VKQHHVDPEE
CIQKAVSQCY VAQNRMLNLE RFHSRECLKD VMVSLSSPKI LTYVLSVASR KFMTTCSEIR
LCHNKVLVLD GAHVLGMMGC LRAVDLSHNW VQDLSSIHSL GNLPLKSLVL HGNKLCRNYR
LPSEYVRAVK EVFPQLTTLD GVDLQTNPGQ SLQKNFLCDT GAYELVGAFL ENYLREFEND
EFRHNLYKYY SENSIFTLTC NYNVVQNHQT PKILQRLSKY NRHARNLRNK DYSKASDGVF
FGCTYIVEIL LQLPRVTHDF HSLQTDVMHY NGKGAVIYVA GLLRDEPPST RNGHGSKTDI
GGVLLGFSRQ FVVTFDEANL GLGKRARRLK IANERLHITN PSKTAIRNAF SVNFPDPSER
QAEEDSLDVK DHKLLLFQEV TGLISTWVTS IVEEADWDFE RALKLFIQKN ADHEIPDLAF
A
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