ID Q9W6F6_CHICK Unreviewed; 1137 AA.
AC Q9W6F6;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 159.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE Flags: Fragment;
GN Name=erbB4 {ECO:0000313|EMBL:AAD31764.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAD31764.1};
RN [1] {ECO:0000313|EMBL:AAD31764.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hindbrain {ECO:0000313|EMBL:AAD31764.1};
RX PubMed=10328884; DOI=10.1006/mcne.1999.0749;
RA Dixon M., Lumsden A.;
RT "Distribution of neuregulin-1 (nrg1) and erbB4 transcripts in embryonic
RT chick hindbrain.";
RL Mol. Cell. Neurosci. 13:237-258(1999).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AF121963; AAD31764.1; -; mRNA.
DR AlphaFoldDB; Q9W6F6; -.
DR VEuPathDB; HostDB:geneid_395671; -.
DR HOGENOM; CLU_003384_1_1_1; -.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; ISS:AgBase.
DR CDD; cd00064; FU; 3.
DR CDD; cd05110; PTKc_HER4; 1.
DR CDD; cd12092; TM_ErbB4; 1.
DR Gene3D; 6.10.250.880; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049328; TM_ErbB1.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF90; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 1.
DR Pfam; PF21314; TM_ErbB1; 1.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000619-
KW 2}; Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAD31764.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAD31764.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 500..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 566..833
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 691
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 572..580
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 599
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAD31764.1"
SQ SEQUENCE 1137 AA; 127928 MW; 4D616436F87DC84F CRC64;
KFLCFADTIH WQDIVRNPWA SNFTLVPTNG SSGCGRCHKS CTGRCWGPTE NHCQTLTKTV
CAEQCDGRCY GPYVSDCCHR ECAGGCSGPK DTDCFACMNF NDSGACVTQC PQTFVYNPTT
FQLEHNHNAK YTYGAFCVKK CPHNFVVDSS SCVRACPSSK MEVEENGIKM CKPCTDICPK
ACDGIGTGSL VSAQTVDSSN IDKFINCTKI NGNLIFLVTG IHGDPYHTIA AINPEKLNIF
QTVREITGYL NIQSWPENMT DFRVFSNLVT IGGRALYSGL SLLILKQQGI TSLQFQSLKQ
ISAGNIYITD NSNLCYYHTV NWTSLFSTPS QKTVIHRNKK AENCTADGMV CNELCSSDGC
WGPGPDQCLS CKRFIRGRTC IESCNLYDGE FREFANGSVC MECDPQCEKM EDNMITCYGP
GPDHCTKCFH FKDGPNCVEK CPDGLQGANS FIFKYADEDR ECHPCHPNCT QGCRGPASHD
CIYYPWTRQS TLPQHARTPL IAAGVIGGLF IIVIMGLTFA VYVRRKSIKK KRALRRFLET
ELVEPLTPSG TAPNQAQLRI LKETELKRVK VLGSGAFGTV YKGIWVPEGE TVKIPVAIKI
LNETTGPKAN VEFMDEALIM ASMDHPHLVR LLGVCLSPTI QLVTQLMPHG CLLDYVHEHK
DNIGSQLLLN WCVQIAKGMM YLEERRLVHR DLAARNVLVK SPNHVKITDF GLARLLEGDE
KEYNADGGKM PIKWMALECI HYRKFTHQSD VWSYGVTIWE LMTFGGKPYD GIPTREIPDL
LEKGERLPQP PICTIDVYMV MVKCWMIDAD SRPKFKELAA EFSRMARDPQ RYLVIQGDDR
MKLPSPNDSK FFQNLLDEED LEDMMDAEEY LVPQAFNIPP PIYTSRTRID SNRNQFVYRD
GGYAAEQGVP MPYRAPGCII PEAPVAQGAT AEIFEDTCCN GTLRKQVATL AKEDSSTQRY
SADPTVFIPE RVIRGELDED GYMTPMRDKP KTDYLNPVEE NPFVSRRKNG DLQAVDNPEY
HNAPNGQPKA EDEYVNEPLY LNTFANTLEN AEYLKNNLPE KAKKAFDNPD YWNHSLPPRS
TLQHPDYLQE YSTKYFYKQN GRIRPIVAEN PEYLSEFSLK PGTVLPPPPY RHRNTVV
//
