ID Q9W7P9_PAROL Unreviewed; 260 AA.
AC Q9W7P9;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=pancreatic elastase II {ECO:0000256|ARBA:ARBA00038991};
DE EC=3.4.21.71 {ECO:0000256|ARBA:ARBA00038991};
DE Flags: Fragment;
OS Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Pleuronectiformes; Pleuronectoidei; Paralichthyidae;
OC Paralichthys.
OX NCBI_TaxID=8255 {ECO:0000313|EMBL:BAA82370.1};
RN [1] {ECO:0000313|EMBL:BAA82370.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pancreas {ECO:0000313|EMBL:BAA82370.1};
RX PubMed=11742759; DOI=10.1016/S1096-4959(01)00487-0;
RA Suzuki T., Srivastava A.S., Kurokawa T.;
RT "cDNA cloning and phylogenetic analysis of pancreatic serine proteases from
RT Japanese flounder, Paralichthys olivaceus.";
RL Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 131:63-70(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa.
CC Hydrolyzes elastin.; EC=3.4.21.71;
CC Evidence={ECO:0000256|ARBA:ARBA00036026};
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DR EMBL; AB029758; BAA82370.1; -; mRNA.
DR AlphaFoldDB; Q9W7P9; -.
DR MEROPS; S01.155; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24257; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR24257:SF19; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 2B; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Serine protease {ECO:0000256|RuleBase:RU363034}.
FT DOMAIN 23..258
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAA82370.1"
SQ SEQUENCE 260 AA; 27943 MW; 61883CD1B6A66075 CRC64;
LALFVAGAYG CGLPTFPPTI TRVVGGDDVR ENSWPWQVSL QYKSGSNFYH TCGGTLISNQ
WVLTAAHCIG SRTYRVYMGK HNLRNDEAGS IAISPAKIIV HENWDSYRIR NDIALIKLAT
PVTFSDSVMA ACLPDSGDIQ PNGAPCYVTG WGRLWTGGPI ADILQQALLP VVDHATCTRS
DWWGSLVTNS MVCAGGAGDL ASCNGDSGGP LNCQSPDGSW EVHGVVSFGS SMGCNYPKKP
SVFTRVSAYI PWINNVMTTY
//
