ID Q9WII9_9ENTO Unreviewed; 883 AA.
AC Q9WII9;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
GN Name=ORF1 {ECO:0000313|EMBL:CAB40216.1};
OS Echovirus E30.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus B.
OX NCBI_TaxID=41846 {ECO:0000313|EMBL:CAB40216.1};
RN [1] {ECO:0000313|EMBL:CAB40216.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=89T2090 {ECO:0000313|EMBL:CAB40216.1};
RX PubMed=10655344;
RA Bailly J.L., Chambon M., Henquell C., Icart J., Peigue-Lafeuille H.;
RT "Genomic variations in echovirus 30 persistent isolates recovered from a
RT chronically infected immunodeficient child and comparison with the
RT reference strain.";
RL J. Clin. Microbiol. 38:552-557(2000).
CC -!- FUNCTION: Component of immature procapsids, which is cleaved into
CC capsid proteins VP4 and VP2 after maturation (By similarity). Allows
CC the capsid to remain inactive before the maturation step.
CC {ECO:0000256|ARBA:ARBA00025202}.
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; AJ133661; CAB40216.1; -; Genomic_RNA.
DR MEROPS; C03.020; -.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 4.10.80.10; Picornavirus coat protein VP4; 1.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR036988; Pico_P1A_sf.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 3.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..299
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 359..524
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 613..783
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT NON_TER 883
FT /evidence="ECO:0000313|EMBL:CAB40216.1"
SQ SEQUENCE 883 AA; 98027 MW; 96049672E2582520 CRC64;
MGAQVSTQKT GAHETGLNAS GNSIIHYTNI NYYKDSASNS LNRQDFTQDP SKFTEPVKDV
MVKTLPALNS PTVEECGYSD RVRSITLGNS TITTQECANV VVGYGVWPTY LSDSEATAVD
QPTQPDVATC RFYTLESVKW ESSSAGWWWK FPEALSDMGL FGQNMQYHYL GRSGYTIHVQ
CNASKFHQGC LLVVCVPEAE MGAATTDRTM NHTKLSNVGQ AMEFSTEKST DQTGPQTAVH
NAGMGVAVGN LTIFPHQWIN LRTNNSATIV MPYINSVPMD NMYRHYNFTL MVIPFAKLEH
SPQASTYVPI TVTVAPMCAE YNGLRLAGHQ GLPTMNTPGS TQFLTSDDFQ SPSAMPQFDV
TPEIQIPGQV RNLMEIAEVD SVVPVNNTEE HVNSIEAYRI PVRPQTSSGE QVFGFQLQPG
YDSVLKHTLL GEILNYYANW SGSMKLTFMY CGAAMATGKF LIAYSPPGAG VPGSRKDAML
GTHIIWDVGL QSSCVLCVPW ISQTNYRYVT SDVYTDAGYI TCWYQTSIVT PPDIPTTSTI
LCFVSACNDF SVRLLRDTPF ITQQALYQND PESALNRAVG RVADTVASGP VNTEQIPALT
AVETGHTSQV VPSDTMQTRH VVNYHTRSES SIENFMGRAA CVYIARYATE KVNDGLDRYT
NWEITTRQVA QLRRKLEMFT YMRFDLEITF VITSSQRTST TYASDSPPLT HQVMYVPPGG
PIPKSYEDFA WQTSTNPSVF WTEGNAPPRM SIPFMSVGNA YCNFYDGWSH FSQSGVYGYT
TLNNMGRLYF RHVNKSTAYP VDSVARVYFK PKHVKAWVPR APRLCPYLYA RNVNFDVQGV
TESRGKITLD RSTHNPLSNT GAFGQQSGAA YVGNYRLVNR HLA
//
