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Database: UniProt
Entry: Q9WUB8_RAT
LinkDB: Q9WUB8_RAT
Original site: Q9WUB8_RAT 
ID   Q9WUB8_RAT              Unreviewed;      2288 AA.
AC   Q9WUB8;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   27-SEP-2017, entry version 117.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=Cacna1g {ECO:0000313|Ensembl:ENSRNOP00000072061,
GN   ECO:0000313|RGD:68942};
GN   ORFNames=rCG_32907 {ECO:0000313|EMBL:EDM05704.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAD26858.1};
RN   [1] {ECO:0000313|EMBL:AAD26858.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pancreas {ECO:0000313|EMBL:AAD26858.1};
RX   PubMed=10615950;
RA   Zhuang H., Bhattacharjee A., Hu F., Zhang M., Goswami T., Wang L.,
RA   Wu S., Berggren P.O., Li M.;
RT   "Cloning of a T-type Ca2+ channel isoform in insulin-secreting
RT   cells.";
RL   Diabetes 49:59-64(2000).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000072061, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072061,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [3] {ECO:0000313|EMBL:EDM05704.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM05704.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [4] {ECO:0000313|EMBL:EDM05704.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM05704.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [6] {ECO:0000313|Ensembl:ENSRNOP00000072061}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000072061};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; AABR07030343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07030344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07030345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF125161; AAD26858.1; -; mRNA.
DR   EMBL; CH473948; EDM05704.1; -; Genomic_DNA.
DR   UniGene; Rn.86960; -.
DR   Ensembl; ENSRNOT00000092024; ENSRNOP00000072061; ENSRNOG00000060528.
DR   RGD; 68942; Cacna1g.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   HOGENOM; HOG000007742; -.
DR   HOVERGEN; HBG050764; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000060528; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF256; PTHR10037:SF256; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    214    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    342    363       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    369    394       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    745    763       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    775    796       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    866    885       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    942    965       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1279   1297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1317   1338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1350   1369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1414   1436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1516   1539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1614   1635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1647   1670       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1748   1767       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1831   1853       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       80    405       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      744    970       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1277   1549       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1613   1863       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1548   1575       {ECO:0000256|SAM:Coils}.
FT   COILED     1852   1876       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2288 AA;  253478 MW;  B89DBB5A1D81757F CRC64;
     MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG LPYPALAPVV
     FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF
     DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR
     TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR
     CFLPENFSLP LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCSL
     DYETYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM
     YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA
     STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAIGV RAGLLSSPVA RSGQEPQPSG
     SCTRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRVPRASPE IQDRDANGSR RLMLPPPSTP
     TPSGGPPRGA ESVHSFYHAD CHLEPVRCQA PPPRCPSEAS GRTVGSGKVY PTVHTSPPPE
     ILKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI SSPCSKADSG
     ACGPDSCPYC ARTGAGEPES ADHVMPDSDS EAVYEFTQDA QHSDLRDPHS RRRQRSLGPD
     AEPSSVLAFW RLICDTFRKI VDSKYFGRGI MIAILVNTLS MGIEYHEQPE ELTNALEISN
     IVFTSLFALE MLLKLLVYGP FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM
     RVLKLVRFLP ALQRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT
     LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL YNGMASTSSW AALYFIALMT FGNYVLFNLL
     VAILVEGFQA EEIGKREDAS GQLSCIQLPV NSQGGDATKS ESEPDFFSPS VDGDGDRKKR
     LALVALGEHA ELRKSLLPPL IIHTAATPMS LPKSSSTGVG EALGSGSRRT SSSGSAEPGA
     AHHEMKSPPS ARSSPHSPWS AASSWTSRRS SRNSLGRAPS LKRRSPSGER RSLLSGEGQE
     SQDEEESSEE DRASPAGSDH RHRGSLEREA KSSFDLPDTL QVPGLHRTAS GRSSASEHQD
     CNGKSASGRL ARTLRTDDPQ LDGDDDNDEG NLSKGERIQA WVRSRLPACC RERDSWSAYI
     FPPQSRFRLL CHRIITHKMF DHVVLVIIFL NCITIAMERP KIDPHSAERI FLTLSNYIFT
     AVFLAEMTVK VVALGWCFGE QAYLRSSWNV LDGLLVLISV IDILVSMVSD SGTKILGMLR
     VLRLLRTLRP LRVISRAQGL KLVVETLMSS LKPIGNIVVI CCAFFIIFGI LGVQLFKGKF
     FVCQGEDTRN ITNKSDCAEA SYRWVRHKYN FDNLGQALMS LFVLASKDGW VDIMYDGLDA
     VGVDQQPIMN HNPWMLLYFI SFLLIVAFFV LNMFVGVVVE NFHKCRQHQE EEEARRREEK
     RLRRLEKKRR NLMLDDVIAS GSSASAASEA QCKPYYSDYS RFRLLVHHLC TSHYLDLFIT
     GVIGLNVVTM AMEHYQQPQI LDEALKICNY IFTVIFVFES VFKLVAFGFR RFFQDRWNQL
     DLAIVLLSIM GITLEEIEVN ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ
     ALPQVGNLGL LFMLLFFIFA ALGVELFGDL ECDETHPCEG LGRHATFRNF GMAFLTLFRV
     STGDNWNGIM KDTLRDCDQE STCYNTVISP IYFVSFVLTA QFVLVNVVIA VLMKHLEESN
     KEAKEEAELE AELELEMKTL SPQPHSPLGS PFLWPGVEGV NSPDSPKPGA PHTTAHIGAA
     SGFSLEHPTM VPHPEEVPVP LGPDLLTVRK SGVSRTHSLP NDSYMCRNGS TAERSLGHRG
     WGLPKAQSGS ILSVHSQPAD TSCILQLPKD VHYLLQPHGA PTWGAIPKLP PPGRSPLAQR
     PLRRQAAIRT DSLDVQGLGS REDLLSEVSG PSCPLTRSSS FWGGSSIQVQ QRSGIQSKVS
     KHIRLPAPCP GLEPSWAKDP PETRSSLELD TELSWISGDL LPSSQEEPLS PRDLKKCYSV
     ETQSCRRRPG SWLDEQRRHS IAVSCLDSGS QPRLCPSPSS LGGQPLGGPG SRPKKKLSPP
     SISIDPPESQ GSRPPCSPGV CLRRRAPASD SKDPSVSSPL DSTAASPSPK KDTLSLSGLS
     SDPTDMDP
//
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