ID   Q9XCF6_MYCAV            Unreviewed;       974 AA.
AC   Q9XCF6;
DT   01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1999, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=TmtpC {ECO:0000313|EMBL:AAD44230.1};
GN   Name=tmtpC {ECO:0000313|EMBL:AAD44230.1};
OS   Mycobacterium avium.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1764 {ECO:0000313|EMBL:AAD44230.1};
RN   [1] {ECO:0000313|EMBL:AAD44230.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=2151 {ECO:0000313|EMBL:AAD44230.1};
RX   PubMed=14523113; DOI=10.1099/mic.0.26528-0;
RA   Eckstein T.M., Belisle J.T., Inamine J.M.;
RT   "Proposed pathway for the biosynthesis of serovar-specific
RT   glycopeptidolipids in Mycobacterium avium serovar 2.";
RL   Microbiology 149:2797-2807(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; AF143772; AAD44230.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9XCF6; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   NCBIfam; TIGR00833; actII; 1.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        253..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        331..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        765..783
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        790..815
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        821..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        869..887
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        907..927
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          52..382
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          602..938
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   974 AA;  107684 MW;  8D38A76A2EDB96E2 CRC64;
     MTTERVRPPG AFARVIRRLA VFIILGWVAL TLLVTFGVPR LEIVGQQHSV PLAPQDAPAV
     QAMQRMGRDF KESDSDSLRH ACCSEGHHQL GRLTAHAYYD KLVRELRNDT KHVEHVQDLW
     GDRLTQAGAQ SPDGKAVYVQ LNLAGNQGTT LGQESVAAVR DAIARIPPPA GLKAYVTGPA
     ALFSDMQLAG DRSILKMTLI GALIIFIVLL FVYRSVTTVV LLLLTVGIEV FAARGVIAFV
     ANNNLMPLST FAVNLLVALA MAAGTDYAIF FFGRYQEARQ AGEDRATAYF TTYRSVAPVV
     LGSGLTIAGA MLCLSFTRMP IFQTMGLPCS VGMLISVFIA LTLVPAVLTV GGGFGLFDPK
     RAIGFGRWRR IGTAIVRWPT PILTATIAVA LVGLVTLPGY KTSYNNRLYM PDSVPANVGY
     AAADRHFTQS RMMPELLMIE SDHDMRNPAD FLVLHRLAKG VFGVHGISRV QGITRPEGTP
     IQHTSIPFLL SMQQASMHQD IQYMKARMDD MLVQADMIAK QIQILKRIYE LQKRMTDITH
     DSIVKTKEMV VVVNELRDHM SDFEDFFRPL RSYFYWEKHC YDIPICWSLR NIFDTLDGVD
     TLSDKMIDLV RDLDHMDRLM PLLLEQYPEM IAMSEDMRNM LLTNHSTMSG IIGQMDSNSK
     DATAMGEAFD ASKNDDSFYL PPDIFENADF KKAMSQFLSP DGKAARFIIS HRGDPATSEA
     LNRIDKIRSA AEEALKNTPL ENAKIYLAGT ASTFKDFRDG STYDLFIAGV GALCLIFIIM
     LILTRSFIAA LIIVGTVTLS LGASFGLSVL IWQYIFGIQL YWMVLPMSVI VLLAVGSDYN
     LLLVSRMKEE IAAGINTGII RAMGGTGKVV TNAGLVFAFT MASMVVSDLR IIGQVGTTIG
     LGLMFDTLIV RSFMTPTIAA LFGRWFWWPQ LVRRRPASQL LRSEGTRRSV RVLLHQNDDA
     DADTAEIPVP RPTA
//