ID Q9XW68_CAEEL Unreviewed; 272 AA.
AC Q9XW68;
DT 01-NOV-1999, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1999, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587, ECO:0000256|RuleBase:RU365059};
GN Name=gex-4 {ECO:0000313|EMBL:CAA22102.1};
GN ORFNames=CELE_Y75B8A.14 {ECO:0000313|EMBL:CAA22102.1}, Y75B8A.14
GN {ECO:0000313|WormBase:Y75B8A.14};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA22102.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA22102.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA22102.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|ARBA:ARBA00002411}.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- INTERACTION:
CC Q9XW68; P46577: gop-2; NbExp=3; IntAct=EBI-316631, EBI-316619;
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; BX284603; CAA22102.1; -; Genomic_DNA.
DR PIR; T27401; T27401.
DR RefSeq; NP_499587.1; NM_067186.3.
DR AlphaFoldDB; Q9XW68; -.
DR SMR; Q9XW68; -.
DR DIP; DIP-25811N; -.
DR IntAct; Q9XW68; 1.
DR STRING; 6239.Y75B8A.14.1; -.
DR EPD; Q9XW68; -.
DR PaxDb; 6239-Y75B8A-14; -.
DR PeptideAtlas; Q9XW68; -.
DR EnsemblMetazoa; Y75B8A.14.1; Y75B8A.14.1; WBGene00013550.
DR GeneID; 176649; -.
DR KEGG; cel:CELE_Y75B8A.14; -.
DR UCSC; Y75B8A.14; c. elegans.
DR AGR; WB:WBGene00013550; -.
DR WormBase; Y75B8A.14; CE23026; WBGene00013550; -.
DR eggNOG; KOG1534; Eukaryota.
DR GeneTree; ENSGT00950000183172; -.
DR HOGENOM; CLU_037460_0_0_1; -.
DR InParanoid; Q9XW68; -.
DR OMA; CIQYHEA; -.
DR OrthoDB; 168004at2759; -.
DR PhylomeDB; Q9XW68; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00013550; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR CDD; cd17872; GPN3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030228; Gpn3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Proteomics identification {ECO:0007829|EPD:Q9XW68,
KW ECO:0007829|PeptideAtlas:Q9XW68};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
SQ SEQUENCE 272 AA; 30962 MW; 63A3B818E3DDABC6 CRC64;
MKYAQLVMGP AGSGKSTYCS VMYNHCLSTG RTLRMVNLDP ACEVFNYPAV VDVRDLISVN
DVQEDEELIL GPNGALVFCM EYLVQNLEWL HDELDEGEDD YFVIDCPGQI ELYSHLPVMR
QIVDALKSWD FNVCSVFLID TNFVLDAEKF ISGALTALSA MVAIETPAIN VLTKMDLLSE
RNKQLVDEFL ETDTRSIVDQ DETVWNSKHR KLTRTIAQVL EDYSIVKFVP LNCEDEESID
QLLLTIDTTI QYGEDLEVKD HYPEELDPEQ QE
//
