ID WDR7_HUMAN Reviewed; 1490 AA.
AC Q9Y4E6; A7E2C8; Q86UX5; Q86VP2; Q96PS7;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 01-MAY-2013, entry version 97.
DE RecName: Full=WD repeat-containing protein 7;
DE AltName: Full=Rabconnectin-3 beta;
DE AltName: Full=TGF-beta resistance-associated protein TRAG;
GN Name=WDR7; Synonyms=KIAA0541, TRAG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12786944; DOI=10.1046/j.1365-2443.2003.00655.x;
RA Kawabe H., Sakisaka T., Yasumi M., Shingai T., Izumi G., Nagano F.,
RA Deguchi-Tawarada M., Takeuchi M., Nakanishi H., Takai Y.;
RT "A novel rabconnectin-3-binding protein that directly binds a GDP/GTP
RT exchange protein for Rab3A small G protein implicated in Ca(2+)-
RT dependent exocytosis of neurotransmitter.";
RL Genes Cells 8:537-546(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RA Sanders S., Thorgeirsson S.S.;
RT "TRAG: a novel gene associated with TGF-beta resistance.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX.
RT The complete sequences of 100 new cDNA clones from brain which can
RT code for large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
RN [4]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R., Ishikawa K.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9Y4E6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9Y4E6-2; Sequence=VSP_015274;
CC -!- SIMILARITY: Contains 9 WD repeats.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA25467.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY099325; AAM33134.1; -; mRNA.
DR EMBL; AF188125; AAL03983.1; -; mRNA.
DR EMBL; AB011113; BAA25467.2; ALT_INIT; mRNA.
DR EMBL; CH471096; EAW63038.1; -; Genomic_DNA.
DR EMBL; BC050352; AAH50352.1; -; mRNA.
DR EMBL; BC150282; AAI50283.1; -; mRNA.
DR IPI; IPI00289815; -.
DR IPI; IPI00328832; -.
DR PIR; T00272; T00272.
DR RefSeq; NP_056100.2; NM_015285.2.
DR RefSeq; NP_443066.2; NM_052834.2.
DR UniGene; Hs.465213; -.
DR ProteinModelPortal; Q9Y4E6; -.
DR IntAct; Q9Y4E6; 1.
DR STRING; 9606.ENSP00000254442; -.
DR PhosphoSite; Q9Y4E6; -.
DR DMDM; 73920974; -.
DR PaxDb; Q9Y4E6; -.
DR PRIDE; Q9Y4E6; -.
DR Ensembl; ENST00000254442; ENSP00000254442; ENSG00000091157.
DR Ensembl; ENST00000357574; ENSP00000350187; ENSG00000091157.
DR GeneID; 23335; -.
DR KEGG; hsa:23335; -.
DR UCSC; uc002lgk.1; human.
DR UCSC; uc002lgl.1; human.
DR CTD; 23335; -.
DR GeneCards; GC18P054318; -.
DR HGNC; HGNC:13490; WDR7.
DR HPA; HPA042074; -.
DR MIM; 613473; gene.
DR neXtProt; NX_Q9Y4E6; -.
DR PharmGKB; PA37784; -.
DR eggNOG; NOG265456; -.
DR HOGENOM; HOG000001566; -.
DR HOVERGEN; HBG067501; -.
DR InParanoid; Q9Y4E6; -.
DR OMA; RTQEDTV; -.
DR OrthoDB; EOG4G1MFH; -.
DR PhylomeDB; Q9Y4E6; -.
DR ChiTaRS; WDR7; human.
DR GenomeRNAi; 23335; -.
DR NextBio; 45277; -.
DR Bgee; Q9Y4E6; -.
DR CleanEx; HS_WDR7; -.
DR Genevestigator; Q9Y4E6; -.
DR GermOnline; ENSG00000091157; Homo sapiens.
DR Gene3D; 2.130.10.10; -; 4.
DR InterPro; IPR011047; Quinonprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50998; Quin_alc_DH_like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Phosphoprotein;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1 1490 WD repeat-containing protein 7.
FT /FTId=PRO_0000051353.
FT REPEAT 17 56 WD 1.
FT REPEAT 62 104 WD 2.
FT REPEAT 156 199 WD 3.
FT REPEAT 324 366 WD 4.
FT REPEAT 404 443 WD 5.
FT REPEAT 462 507 WD 6.
FT REPEAT 558 597 WD 7.
FT REPEAT 1351 1390 WD 8.
FT REPEAT 1392 1432 WD 9.
FT MOD_RES 935 935 Phosphoserine (By similarity).
FT MOD_RES 1152 1152 Phosphoserine (By similarity).
FT MOD_RES 1154 1154 Phosphoserine (By similarity).
FT MOD_RES 1456 1456 Phosphoserine (By similarity).
FT VAR_SEQ 950 982 Missing (in isoform 2).
FT /FTId=VSP_015274.
FT CONFLICT 54 54 I -> V (in Ref. 2; AAL03983).
SQ SEQUENCE 1490 AA; 163810 MW; 626E876245696A1F CRC64;
MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV ELQINPRALL
FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR CIEFTKLACT HTGIQFYQFS
VGNQREGRLL CHGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSH RTQEDTVVAL
SVTGILKVWI VTSEISDMQD TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV
FDAGDYSLLC SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS GRLNIWNISD
TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI PNSNEPLKVT ASVYIPAHGR
LVCGREDGSI VIVPATQTAI VQLLQGEHML RRGWPPHRTL RGHRNKVTCL LYPHQVSARY
DQRYLISGGV DFSVIIWDIF SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH
SVGLLSLREK KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT LATNLLASEA
SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII QLLTEEASRP NTALISPENL
QKASGSSDKG GSFLTGKRAA VLFQQVKETI KENIKEHLLD DEEEDEEIMR QRREESDPEY
RSSKSKPLTL LEYNLTMDTA KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR
GGHMSLMLPG YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV AAPVVSARSD
ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG LDKFRPPLLE MLARRWQDRC
LEVREAAQAL LLAELRRIEQ AGRKEAIDAW APYLPQYIDH VISPGVTSEA AQTITTAPDA
SGPEAKVQEE EHDLVDDDIT TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE
IEPPKLLTRP RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD SARSARHALS
LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA RAKGEILRVI EILIEKMPTD
VVDLLVEVMD IIMYCLEGSL VKKKGLQECF PAICRFYMVS YYERNHRIAV GARHGSVALY
DIRTGKCQTI HGHKGPITAV AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ
LRCIKTYQVP PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV
//
