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Database: UniProt
Entry: Q9Y4E6
LinkDB: Q9Y4E6
Original site: Q9Y4E6 
ID   WDR7_HUMAN              Reviewed;        1490 AA.
AC   Q9Y4E6; A7E2C8; Q86UX5; Q86VP2; Q96PS7;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   19-MAR-2014, entry version 105.
DE   RecName: Full=WD repeat-containing protein 7;
DE   AltName: Full=Rabconnectin-3 beta;
DE   AltName: Full=TGF-beta resistance-associated protein TRAG;
GN   Name=WDR7; Synonyms=KIAA0541, TRAG;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=12786944; DOI=10.1046/j.1365-2443.2003.00655.x;
RA   Kawabe H., Sakisaka T., Yasumi M., Shingai T., Izumi G., Nagano F.,
RA   Deguchi-Tawarada M., Takeuchi M., Nakanishi H., Takai Y.;
RT   "A novel rabconnectin-3-binding protein that directly binds a GDP/GTP
RT   exchange protein for Rab3A small G protein implicated in Ca(2+)-
RT   dependent exocytosis of neurotransmitter.";
RL   Genes Cells 8:537-546(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC   TISSUE=Liver;
RA   Sanders S., Thorgeirsson S.S.;
RT   "TRAG: a novel gene associated with TGF-beta resistance.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA   Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA   Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. IX.
RT   The complete sequences of 100 new cDNA clones from brain which can
RT   code for large proteins in vitro.";
RL   DNA Res. 5:31-39(1998).
RN   [4]
RP   SEQUENCE REVISION.
RA   Ohara O., Nagase T., Kikuno R., Ishikawa K.;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [8]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Leukemic T-cell;
RX   PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA   Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA   Rodionov V., Han D.K.;
RT   "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT   reveals system-wide modulation of protein-protein interactions.";
RL   Sci. Signal. 2:RA46-RA46(2009).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9Y4E6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y4E6-2; Sequence=VSP_015274;
CC   -!- SIMILARITY: Contains 9 WD repeats.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA25467.2; Type=Erroneous initiation;
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DR   EMBL; AY099325; AAM33134.1; -; mRNA.
DR   EMBL; AF188125; AAL03983.1; -; mRNA.
DR   EMBL; AB011113; BAA25467.2; ALT_INIT; mRNA.
DR   EMBL; CH471096; EAW63038.1; -; Genomic_DNA.
DR   EMBL; BC050352; AAH50352.1; -; mRNA.
DR   EMBL; BC150282; AAI50283.1; -; mRNA.
DR   PIR; T00272; T00272.
DR   RefSeq; NP_056100.2; NM_015285.2.
DR   RefSeq; NP_443066.2; NM_052834.2.
DR   UniGene; Hs.465213; -.
DR   ProteinModelPortal; Q9Y4E6; -.
DR   SMR; Q9Y4E6; 4-105, 1357-1427.
DR   BioGrid; 116922; 2.
DR   IntAct; Q9Y4E6; 1.
DR   STRING; 9606.ENSP00000254442; -.
DR   PhosphoSite; Q9Y4E6; -.
DR   DMDM; 73920974; -.
DR   PaxDb; Q9Y4E6; -.
DR   PRIDE; Q9Y4E6; -.
DR   Ensembl; ENST00000254442; ENSP00000254442; ENSG00000091157. [Q9Y4E6-1]
DR   Ensembl; ENST00000357574; ENSP00000350187; ENSG00000091157. [Q9Y4E6-2]
DR   GeneID; 23335; -.
DR   KEGG; hsa:23335; -.
DR   UCSC; uc002lgk.1; human. [Q9Y4E6-1]
DR   UCSC; uc002lgl.1; human. [Q9Y4E6-2]
DR   CTD; 23335; -.
DR   GeneCards; GC18P054318; -.
DR   HGNC; HGNC:13490; WDR7.
DR   HPA; HPA042074; -.
DR   MIM; 613473; gene.
DR   neXtProt; NX_Q9Y4E6; -.
DR   PharmGKB; PA37784; -.
DR   eggNOG; NOG265456; -.
DR   HOGENOM; HOG000001566; -.
DR   HOVERGEN; HBG067501; -.
DR   InParanoid; Q9Y4E6; -.
DR   OMA; ILKVWIV; -.
DR   OrthoDB; EOG72VH5G; -.
DR   PhylomeDB; Q9Y4E6; -.
DR   TreeFam; TF313196; -.
DR   SignaLink; Q9Y4E6; -.
DR   ChiTaRS; WDR7; human.
DR   GenomeRNAi; 23335; -.
DR   NextBio; 45277; -.
DR   PRO; PR:Q9Y4E6; -.
DR   ArrayExpress; Q9Y4E6; -.
DR   Bgee; Q9Y4E6; -.
DR   CleanEx; HS_WDR7; -.
DR   Genevestigator; Q9Y4E6; -.
DR   Gene3D; 2.130.10.10; -; 4.
DR   InterPro; IPR011047; Quinonprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF50998; SSF50998; 4.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN         1   1490       WD repeat-containing protein 7.
FT                                /FTId=PRO_0000051353.
FT   REPEAT       17     56       WD 1.
FT   REPEAT       62    104       WD 2.
FT   REPEAT      156    199       WD 3.
FT   REPEAT      324    366       WD 4.
FT   REPEAT      404    443       WD 5.
FT   REPEAT      462    507       WD 6.
FT   REPEAT      558    597       WD 7.
FT   REPEAT     1351   1390       WD 8.
FT   REPEAT     1392   1432       WD 9.
FT   VAR_SEQ     950    982       Missing (in isoform 2).
FT                                /FTId=VSP_015274.
FT   CONFLICT     54     54       I -> V (in Ref. 2; AAL03983).
SQ   SEQUENCE   1490 AA;  163810 MW;  626E876245696A1F CRC64;
     MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV ELQINPRALL
     FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR CIEFTKLACT HTGIQFYQFS
     VGNQREGRLL CHGHYPEILV VDATSLEVLY SLVSKISPDW ISSMSIIRSH RTQEDTVVAL
     SVTGILKVWI VTSEISDMQD TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV
     FDAGDYSLLC SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
     GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS GRLNIWNISD
     TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI PNSNEPLKVT ASVYIPAHGR
     LVCGREDGSI VIVPATQTAI VQLLQGEHML RRGWPPHRTL RGHRNKVTCL LYPHQVSARY
     DQRYLISGGV DFSVIIWDIF SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH
     SVGLLSLREK KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
     ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT LATNLLASEA
     SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII QLLTEEASRP NTALISPENL
     QKASGSSDKG GSFLTGKRAA VLFQQVKETI KENIKEHLLD DEEEDEEIMR QRREESDPEY
     RSSKSKPLTL LEYNLTMDTA KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR
     GGHMSLMLPG YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
     LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV AAPVVSARSD
     ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG LDKFRPPLLE MLARRWQDRC
     LEVREAAQAL LLAELRRIEQ AGRKEAIDAW APYLPQYIDH VISPGVTSEA AQTITTAPDA
     SGPEAKVQEE EHDLVDDDIT TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE
     IEPPKLLTRP RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
     AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD SARSARHALS
     LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA RAKGEILRVI EILIEKMPTD
     VVDLLVEVMD IIMYCLEGSL VKKKGLQECF PAICRFYMVS YYERNHRIAV GARHGSVALY
     DIRTGKCQTI HGHKGPITAV AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ
     LRCIKTYQVP PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV
//
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