ID SOX21_HUMAN Reviewed; 276 AA.
AC Q9Y651; P35715; Q15504; Q5TBS1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 01-MAY-2013, entry version 108.
DE RecName: Full=Transcription factor SOX-21;
DE AltName: Full=SOX-A;
GN Name=SOX21; Synonyms=SOX25, SOXA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10441749; DOI=10.1007/s003359901118;
RA Malas S., Duthie S., Deloukas P., Episkopou V.;
RT "The isolation and high-resolution chromosomal mapping of human SOX14
RT and SOX21; two members of the SOX gene family related to SOX1, SOX2,
RT and SOX3.";
RL Mamm. Genome 10:934-937(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-87.
RC TISSUE=Spinal cord;
RA Stevanovic M.;
RL Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 19-72.
RX PubMed=1614875; DOI=10.1093/nar/20.11.2887;
RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.;
RT "A conserved family of genes related to the testis determining gene,
RT SRY.";
RL Nucleic Acids Res. 20:2887-2887(1992).
CC -!- FUNCTION: May play a role as an activator of transcription of
CC OPRM1 (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- SIMILARITY: Contains 1 HMG box DNA-binding domain.
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DR EMBL; AF107044; AAC95381.1; -; Genomic_DNA.
DR EMBL; AL137061; CAI14398.1; -; Genomic_DNA.
DR EMBL; CH471085; EAX08946.1; -; Genomic_DNA.
DR EMBL; X71136; CAA50466.1; -; mRNA.
DR EMBL; X65666; CAA46617.1; -; mRNA.
DR IPI; IPI00001824; -.
DR PIR; I38238; I38238.
DR PIR; S22937; S22937.
DR RefSeq; NP_009015.1; NM_007084.2.
DR UniGene; Hs.187577; -.
DR ProteinModelPortal; Q9Y651; -.
DR PhosphoSite; Q9Y651; -.
DR DMDM; 6831690; -.
DR PaxDb; Q9Y651; -.
DR PRIDE; Q9Y651; -.
DR DNASU; 11166; -.
DR Ensembl; ENST00000376945; ENSP00000366144; ENSG00000125285.
DR GeneID; 11166; -.
DR KEGG; hsa:11166; -.
DR UCSC; uc001vma.3; human.
DR CTD; 11166; -.
DR GeneCards; GC13M095361; -.
DR H-InvDB; HIX0037360; -.
DR HGNC; HGNC:11197; SOX21.
DR MIM; 604974; gene.
DR neXtProt; NX_Q9Y651; -.
DR PharmGKB; PA36034; -.
DR eggNOG; NOG302715; -.
DR HOGENOM; HOG000231647; -.
DR HOVERGEN; HBG105618; -.
DR InParanoid; Q9Y651; -.
DR KO; K09267; -.
DR OMA; KPKTLMK; -.
DR OrthoDB; EOG4S1T8V; -.
DR PhylomeDB; Q9Y651; -.
DR GenomeRNAi; 11166; -.
DR NextBio; 42483; -.
DR Bgee; Q9Y651; -.
DR CleanEx; HS_SOX21; -.
DR Genevestigator; Q9Y651; -.
DR GermOnline; ENSG00000125285; Homo sapiens.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; NAS:UniProtKB.
DR GO; GO:0001942; P:hair follicle development; IEA:Compara.
DR GO; GO:0043588; P:skin development; IEA:Compara.
DR GO; GO:0048863; P:stem cell differentiation; IDA:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR022097; TF_SOX.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Complete proteome; DNA-binding; Nucleus; Polymorphism;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1 276 Transcription factor SOX-21.
FT /FTId=PRO_0000048770.
FT DNA_BIND 8 76 HMG box.
FT VARIANT 230 230 G -> R (in dbSNP:rs6492735).
FT /FTId=VAR_049562.
FT CONFLICT 41 41 R -> P (in Ref. 4; CAA50466).
FT CONFLICT 83 83 P -> T (in Ref. 4; CAA50466).
SQ SEQUENCE 276 AA; 28580 MW; 99DC899B7EC9A96B CRC64;
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE
AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG
AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA
EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC
SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL
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