ID Q9YHB7_CHICK Unreviewed; 219 AA.
AC Q9YHB7;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE SubName: Full=Homeodomain protein {ECO:0000313|EMBL:AAD04630.1};
DE Flags: Fragment;
GN Name=Nkx-2.2 {ECO:0000313|EMBL:AAD04630.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAD04630.1};
RN [1] {ECO:0000313|EMBL:AAD04630.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9533954; DOI=10.1016/S0925-4773(98)00018-5;
RA Qiu M., Shimamura K., Sussel L., Chen S., Rubenstein J.L.;
RT "Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene
RT expression relative to other Nkx genes during vertebrate CNS development.";
RL Mech. Dev. 72:77-88(1998).
RN [2] {ECO:0000313|EMBL:AAD04630.1}
RP NUCLEOTIDE SEQUENCE.
RA Qiu M.S., Li G.Y., Sussel L., Rubenstein J.L.R.;
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the NK-2 homeobox family.
CC {ECO:0000256|ARBA:ARBA00005661}.
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DR EMBL; AF110994; AAD04630.1; -; mRNA.
DR AlphaFoldDB; Q9YHB7; -.
DR VEuPathDB; HostDB:geneid_428549; -.
DR PhylomeDB; Q9YHB7; -.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24340; HOMEOBOX PROTEIN NKX; 1.
DR PANTHER; PTHR24340:SF24; HOMEOBOX PROTEIN NKX-2.2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 73..133
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 75..134
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 37..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAD04630.1"
SQ SEQUENCE 219 AA; 24424 MW; 7609185635BD0660 CRC64;
VDAVQTLPLK PPFYDNSDNP YTRWLASAEG IQYSLHGLAA GAGGPEAGSK SPEPSADESP
DNEKEAAGGG DAGKKRKRRV LFSKAQTYEL ERRFRQQRYL SAPEKEHLAS LIRLTPTQVK
IWFQNHRYKM KRAPKKGMEV NPLPSPRRVA VPVLLRDGKP CHTLKAQDLA AATFQTGIPF
SAYSAHSLQH MQYNAHYSAA GSPHYPTAHH LVQAQQWTW
//