ID Q9Z4N7_ENTFL Unreviewed; 1873 AA.
AC Q9Z4N7;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 24-JAN-2024, entry version 114.
DE SubName: Full=EF0056 {ECO:0000313|EMBL:AAM75261.1};
DE SubName: Full=Surface protein {ECO:0000313|EMBL:AAD09858.1};
GN Name=esp {ECO:0000313|EMBL:AAK67274.1};
GN Synonyms=ef0056 {ECO:0000313|EMBL:AAM75261.1};
OS Enterococcus faecalis (Streptococcus faecalis).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1351 {ECO:0000313|EMBL:AAD09858.1};
RN [1] {ECO:0000313|EMBL:AAD09858.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MMH594 {ECO:0000313|EMBL:AAD09858.1};
RX PubMed=9864215;
RA Shankar V., Baghdayan A.S., Huycke M.M., Lindahl G., Gilmore M.S.;
RT "Infection-derived Enterococcus faecalis strains are enriched in esp, a
RT gene encoding a novel surface protein.";
RL Infect. Immun. 67:193-200(1999).
RN [2] {ECO:0000313|EMBL:AAM21183.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=V586 {ECO:0000313|EMBL:AAM21183.1};
RA Shankar N., Baghdayan A.S., Gilmore M.S.;
RT "Organization of a chromosomal locus that harbors the genes for Esp and
RT chromosomal cytolysin in virulent Enterococcus faecalis.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAK67274.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MMH594 {ECO:0000313|EMBL:AAK67274.1};
RA Shankar N., Baghdayan A.S., Gilmore M.S.;
RT "A pathogenicity island in virulent Enterococcus faecalis.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAM75261.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12066186; DOI=10.1038/nature00802;
RA Shankar N., Baghdayan A.S., Gilmore M.S.;
RT "Modulation of virulence within a pathogenicity island in vancomycin-
RT resistant Enterococcus faecalis.";
RL Nature 417:746-750(2002).
RN [5] {ECO:0007829|PDB:6ORI}
RP X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 48-452.
RA Spiegelman L., Zhang L., Tezcan A., Ghosh P.;
RT "Enterococcal surface protein, partial N-terminal region (CASP target).";
RL Submitted (APR-2019) to the PDB data bank.
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DR EMBL; AF034779; AAD09858.1; -; Genomic_DNA.
DR EMBL; AY032999; AAK67274.1; -; Genomic_DNA.
DR EMBL; AF329367; AAM21183.1; -; Genomic_DNA.
DR EMBL; AF454824; AAM75261.1; -; Genomic_DNA.
DR PIR; T30944; T30944.
DR PDB; 6ORI; X-ray; 1.40 A; A=48-452.
DR SMR; Q9Z4N7; -.
DR PHI-base; PHI:7674; -.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR041498; Big_6.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR012706; Rib_alpha_Esp_rpt.
DR InterPro; IPR044055; RibLong.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; TIGR02331; rib_alpha; 9.
DR NCBIfam; TIGR01168; YSIRK_signal; 1.
DR Pfam; PF17936; Big_6; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF08428; Rib; 10.
DR Pfam; PF18957; RibLong; 1.
DR Pfam; PF04650; YSIRK_signal; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6ORI};
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1837..1873
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 451..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1649..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1789..1830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1873 AA; 202085 MW; F609483DB9B80621 CRC64;
MFGKNNKHMI LKKGRKRVLK YSIKKLSVGV ASVLVGVGLV FGATGIVNAQ MGEGRLANYS
ASGNTFQENP GYTKNYNFSD LQFNPKAITG DVLQGNTIDF EVYGKHNIAA STANWEIRLQ
LDERLAQYVE KIQVDPKKGV GNSRRTFVRI NDSLGRPTNI WKVNYIRAND GLFAGAETTD
TQTAPNGVIT FEKNLDEIFK EIGADNLKSD RLMYRIYLVS HQDDDKIVPG IESTGYFLTD
QDDFYNKLDV SENNSDQFKH GSVNTKYEEA NIQTKDGSGS TGANGAIILD HKLTKEKNFS
YSTSAKGTPW YANYKIDERL VPYVSGIQMH MVQADKVAYN VAFESGKKVA DLAIERREGH
ENYGMGSITD NDLTKLIDFA NASPRPIVVR YVLQLTKPLD EILEEMKAAD KIEENAPFGE
DFIFDSWLSD TNKKLIQNTY GTGYYYLQDI DGDGNPDDKE ESGDTNPYIG KPELEEVYDV
DTTVKGKVFI HELAGTGHKA QLVDKEGTVL AEKTIAPNEK DGAPISDTVE FEFTGVDSSK
LIAKDELKIQ IVSPGFDKPE EGSTVIKESP KAVDKQTVVV GFKPDAKESI RNNKNLPEDA
EYSWKTEPDT SNVTDSTKGI VTVKIGNRTF DVDVEFAVKA SQAMENDATY VPITTTPETT
IQSGKPTFDK PDVPLANDAF SVLDVYNKDF GNASVDANTG IVTFTPAKGV GESEPITGTI
PIKIVYQDGS VGTTDLAVTV SKNIYENPGE NIPAGYHKVT FTAGEGTSIE SGTTVFAVKD
GVSLPEDKLP VLKAKDGYTD AKWPEEATQP IKADDTEFVS SATKLDDIIE NPGDNIPAGY
HKVTFTAGEG TSIESGTTVF AVKDGVSLPE DKLPVLKAKD GYTDAKWPEE ATQPIKADDT
EFVSSATKLD DIIENPGDNI PAGYHKVTFT AGEGTSIESG TTVFAVKDGV SLPEDKLPVL
KAKDGYTDAK WPGEATQPIK ADDTEFVSSA TKLDDKSDAD KYTPEGQKVT TELNKEPDAS
EGIKNKKDLP KDAKYTWKEK VDISTAGNKK GTVVVTYSDG SSDEVEVDVT VTDNRSDADK
YEPTVEGEKV EIGGKVDLTD NVTNLPTLPQ GTTVTDVTPG GTIDTNTPGN YEGVIEVTYP
DGTKDTVKVP VEVTDNRSDA DKYEPTVEGE KVEIGGKVDL TDNVTNLPTL PQGTTVTDVT
PGGTIDTNTP GNYEGVIEVT YPDGTKDTVK VPVEVTDNRS DADKYEPTVE GEKVEIGGKV
DLTDNVTNLP TLPQGTTVTD VTPGGTIDTN TPGNYEGVIE VTYPDGTKDT VKVPVEVTDN
RSDADKYTPM VEGEKVEIGG KVDLTDNVTN LPTLPQGTTV TDVTPGGTID TNTPGNYEGV
IEVTYPDGTK DTVKVPVEVT DNRSDADKYE PTVEGEKVEI GGKVDLTDNV TNLPTLPQGT
TVTDVTPGGT IDTNTPGNYE GVIEVTYPDG TKDTVKVPVE VTDNRSDADK YEPTVEGEKV
EIGGKVDLTD NVTNLPTLPQ GTTITDVTPG GTIDTNTPGN YEGVIEVTYP DGTKDTVKVP
VEVTDNRSDA DKYEPTVEGE KVEIGGKVDL TDNVTNLPTL PQGTTITDVT PGGTIDTNTP
GNYEGVIEVT YPDGTKDTVK VPVEVTDNRS DADKYTPKGQ KVTTELNKEP EASDGIKNKS
DLPKGTMYFW KEKVDVGIPG NKKATVVVIY PDGSKEEVEV VISVVDKKAP NKPQVDPITD
GDKIVTGKTE PNADVTVTLP DGSQYHGTAD KSGYFKVNVP KLEAGTKVKV TSTDESGNTS
EPTDVVVSSN ELNGGKGNGT DSKTNNNQDK KQFLKTYPKT GEVDSNIYTI AGGLILLGTL
GLLGYEKWKK EDE
//