ID Q9Z568_STRCO Unreviewed; 1108 AA.
AC Q9Z568;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=Membrane associated phophodiesterase {ECO:0000313|EMBL:CAB37587.1};
GN OrderedLocusNames=SCO5511 {ECO:0000313|EMBL:CAB37587.1};
GN ORFNames=SC8D9.23 {ECO:0000313|EMBL:CAB37587.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB37587.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB37587.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
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DR EMBL; AL939124; CAB37587.1; -; Genomic_DNA.
DR PIR; T35827; T35827.
DR RefSeq; NP_629646.1; NC_003888.3.
DR AlphaFoldDB; Q9Z568; -.
DR STRING; 100226.gene:17763163; -.
DR PaxDb; 100226-SCO5511; -.
DR PATRIC; fig|100226.15.peg.5597; -.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_129_3_11; -.
DR InParanoid; Q9Z568; -.
DR OrthoDB; 23692at2; -.
DR PhylomeDB; Q9Z568; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00989; PAS; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 107..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 485..555
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 646..784
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 793..1047
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..401
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 116316 MW; 7A6DAEDC27947A5A CRC64;
MDRRSDAAEP PPATLAHGHD HDRAPTGSAR PPRRPARSAL PPPAPTGRPQ QAGPAGPPVR
AGRGSGADPE APVSPPPAPT LDGALRGQAA PGPLLPRPSA AAGGPPLVRQ LVLALVCAAY
AVGAALGWGS QYVAKIMGDF GLSAAAAAAA VSCFLYARGR RVRFRPAWLL FALSSAMASL
GNLVWGWYEV VLRVPVPNPS YADLFFLCFA PPAIVGLLVL AKRPVTKAGW ICLGLDAWLI
GGSLLTLAWS LALAQAAKAE GGSSVAHAAL SVAYPLLDIA LVSMVLALHF RRSPVCRSAV
NTAIGALALT VVCDALFTSP LLHNSYRSGQ LLDAGWFAGS LLLAYAPWAA SRRGRATPDE
TGTGGHTRVV REHVPGQRGS GHQPPPPSAP SAPPPSAPTA LPGPGQGGER GRYPAARPIA
GSLAALTPYL AAAVCTLGIL YNVLNGRSVD RVVLLTGGTV VLALVVRQGI MLLDNIVLTQ
ELAQKENHFR SLVQGSSDVI MIAAPNGILR YVSPAAAGVY GRPAEELVGT ELAGLIHPED
LGCVVHEVRR FLAANPVEEP TTRIECRFRS GGGGGWLNVE STVNRHHGGL IFNSRDVTER
VRLQAQLQHN AEHDPLTDLP NRALFTRRVQ QALSGRRASD RGAALRGTAV LFIDLDGFKG
VNDTIGHQAG DELLVQAARR LHEAVRKGDT ASRLGGDEFA ALIVGDGARD RAAREGHIRE
LADRLRLTLS QPYLIDGNEV RVNASIGVAF AEPGLGAGEL LRNADLAMYR AKAGGKGRVE
LYRPQMQQDV VRKAELATRL RAALHDGEFA LLHQPVVSLT DGRITSVCAQ ARWRSSQGVL
FTPAEFLRVT EEGDRTAELD RWVLREAVEQ AAERAAAGLS VSVAIRIGAR RLLDRSMPLG
SVEALLTRHG LPPGSLVIEL SDIDPRVGLD ELDRRLNALR RVGVRIALDG FGSGYAAITA
LRRLPVDVLK LDRGLVEGVV ESARLHKITS GLLRIATDLG LKSVADGVDL PEQIVALRAM
GCTHGQGMAF SGALDEYRLR RALAAGHYPV PHGPAEPAFA GGGAGVYAKG VGGPGPGQVT
GGVPSGLPAV LSGGTALRSH NETPVPPT
//
