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Database: UniProt
Entry: Q9Z9C7
LinkDB: Q9Z9C7
Original site: Q9Z9C7 
ID   RNC_CHLPN               Reviewed;         237 AA.
AC   Q9Z9C7; Q9JQ21;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   01-OCT-2014, entry version 101.
DE   RecName: Full=Ribonuclease 3 {ECO:0000255|HAMAP-Rule:MF_00104};
DE            EC=3.1.26.3 {ECO:0000255|HAMAP-Rule:MF_00104};
DE   AltName: Full=Ribonuclease III {ECO:0000255|HAMAP-Rule:MF_00104};
DE            Short=RNase III {ECO:0000255|HAMAP-Rule:MF_00104};
GN   Name=rnc {ECO:0000255|HAMAP-Rule:MF_00104};
GN   OrderedLocusNames=CPn_0054, CP_0721, CpB0055;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA   White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA   Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA   Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA   McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT   pneumoniae AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT   from Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC       of primary rRNA transcript to yield the immediate precursors to
CC       the large and small rRNAs (23S and 16S). Processes some mRNAs, and
CC       tRNAs when they are encoded in the rRNA operon. Processes pre-
CC       crRNA and tracrRNA of type II CRISPR loci if present in the
CC       organism. {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC       phosphomonoester. {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- COFACTOR: Mg(2+). {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC       {ECO:0000255|HAMAP-Rule:MF_00104}.
CC   -!- SIMILARITY: Contains 1 RNase III domain. {ECO:0000255|HAMAP-
CC       Rule:MF_00104}.
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DR   EMBL; AE001363; AAD18207.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38526.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA98265.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP97988.1; -; Genomic_DNA.
DR   PIR; D72126; D72126.
DR   PIR; G86497; G86497.
DR   RefSeq; NP_224262.1; NC_000922.1.
DR   RefSeq; NP_300114.1; NC_002491.1.
DR   RefSeq; NP_445263.1; NC_002179.2.
DR   RefSeq; NP_876331.1; NC_005043.1.
DR   ProteinModelPortal; Q9Z9C7; -.
DR   STRING; 115713.CPn0054; -.
DR   EnsemblBacteria; AAD18207; AAD18207; CPn_0054.
DR   EnsemblBacteria; AAF38526; AAF38526; CP_0721.
DR   EnsemblBacteria; AAP97988; AAP97988; CpB0055.
DR   EnsemblBacteria; BAA98265; BAA98265; BAA98265.
DR   GeneID; 1466738; -.
DR   GeneID; 895023; -.
DR   GeneID; 918843; -.
DR   GeneID; 963180; -.
DR   KEGG; cpa:CP0721; -.
DR   KEGG; cpj:CPj0054; -.
DR   KEGG; cpn:CPn0054; -.
DR   KEGG; cpt:CpB0055; -.
DR   eggNOG; COG0571; -.
DR   HOGENOM; HOG000246808; -.
DR   KO; K03685; -.
DR   OMA; TFKDQEL; -.
DR   OrthoDB; EOG6T1WVS; -.
DR   BioCyc; CPNE115711:GI7B-746-MONOMER; -.
DR   BioCyc; CPNE115713:GHEY-54-MONOMER; -.
DR   BioCyc; CPNE138677:GH8N-55-MONOMER; -.
DR   BioCyc; CPNE182082:GH4N-55-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.20; -; 1.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRNA-bd_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   PANTHER; PTHR11207; PTHR11207; 1.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 1.
DR   SUPFAM; SSF69065; SSF69065; 1.
DR   TIGRFAMs; TIGR02191; RNaseIII; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW   Metal-binding; mRNA processing; Nuclease; RNA-binding;
KW   rRNA processing; rRNA-binding; tRNA processing.
FT   CHAIN         1    237       Ribonuclease 3.
FT                                /FTId=PRO_0000180387.
FT   DOMAIN        7    135       RNase III. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   DOMAIN      160    229       DRBM. {ECO:0000255|HAMAP-Rule:MF_00104}.
FT   ACT_SITE     52     52       {ECO:0000255|HAMAP-Rule:MF_00104}.
FT   ACT_SITE    124    124       {ECO:0000255|HAMAP-Rule:MF_00104}.
FT   METAL        48     48       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   METAL       121    121       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   METAL       124    124       Magnesium. {ECO:0000255|HAMAP-
FT                                Rule:MF_00104}.
FT   CONFLICT     94     94       M -> V (in Ref. 4; AAP97988).
FT                                {ECO:0000305}.
SQ   SEQUENCE   237 AA;  26088 MW;  EF9E79A5739EDAAE CRC64;
     MHPPIDITAI EAKLNFTFTQ PKLLEIALTH PSYKNESAVQ IEDSERLEFL GDAVLGLIVT
     EHLFLLFPSM DEGTLSTARA SLVNAKACCR YTTMLGIGDY LLIGKGEKIQ SERGRLSAYA
     NLFESILGAV YLDGGLSPAR KLTVPLLPPR EEILPLMSGN PKNLLQQFTQ KQFRVLPVYQ
     STAVTDAQGN VSYQIQVLVN QEVWGEGNAS SKKEAEKIAA QQALDTYGNK NQNTMDV
//
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