ID RNC_CHLPN Reviewed; 237 AA.
AC Q9Z9C7; Q9JQ21;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 01-MAY-2013, entry version 92.
DE RecName: Full=Ribonuclease 3;
DE EC=3.1.26.3;
DE AltName: Full=Ribonuclease III;
DE Short=RNase III;
GN Name=rnc; OrderedLocusNames=CPn_0054, CP_0721, CpB0055;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F.,
RA White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J.,
RA Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C.,
RA Dodson R.J., Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F.,
RA McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia
RT pneumoniae AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138
RT from Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Digests double-stranded RNA. Involved in the processing
CC of primary rRNA transcript to yield the immediate precursors to
CC the large and small rRNAs (23S and 16S). Also processes some
CC mRNAs, and tRNAs when they are encoded in the rRNA operon (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
CC phosphomonoester.
CC -!- COFACTOR: Mg(2+) (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Contains 1 DRBM (double-stranded RNA-binding) domain.
CC -!- SIMILARITY: Contains 1 RNase III domain.
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DR EMBL; AE001363; AAD18207.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38526.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98265.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP97988.1; -; Genomic_DNA.
DR PIR; D72126; D72126.
DR PIR; G86497; G86497.
DR RefSeq; NP_224262.1; NC_000922.1.
DR RefSeq; NP_300114.1; NC_002491.1.
DR RefSeq; NP_445263.1; NC_002179.2.
DR RefSeq; NP_876331.1; NC_005043.1.
DR ProteinModelPortal; Q9Z9C7; -.
DR STRING; 115713.CPn0054; -.
DR EnsemblBacteria; AAD18207; AAD18207; CPn_0054.
DR EnsemblBacteria; AAF38526; AAF38526; CP_0721.
DR EnsemblBacteria; AAP97988; AAP97988; CpB0055.
DR EnsemblBacteria; BAA98265; BAA98265; BAA98265.
DR GeneID; 1466738; -.
DR GeneID; 895023; -.
DR GeneID; 918843; -.
DR GeneID; 963180; -.
DR KEGG; cpa:CP0721; -.
DR KEGG; cpj:CPj0054; -.
DR KEGG; cpn:CPn0054; -.
DR KEGG; cpt:CpB0055; -.
DR eggNOG; COG0571; -.
DR HOGENOM; HOG000246808; -.
DR KO; K03685; -.
DR OMA; SAYANLF; -.
DR ProtClustDB; PRK00102; -.
DR BioCyc; CPNE115711:GI7B-719-MONOMER; -.
DR BioCyc; CPNE115713:GHEY-57-MONOMER; -.
DR BioCyc; CPNE138677:GH8N-52-MONOMER; -.
DR BioCyc; CPNE182082:GH4N-56-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:HAMAP.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:HAMAP.
DR GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:HAMAP.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1520.10; -; 1.
DR Gene3D; 3.30.160.20; -; 1.
DR HAMAP; MF_00104; RNase_III; 1; -.
DR InterPro; IPR001159; Ds-RNA-bd.
DR InterPro; IPR014720; dsRNA-bd-like_dom.
DR InterPro; IPR011907; RNase_III.
DR InterPro; IPR000999; RNase_III_dom.
DR PANTHER; PTHR11207; PTHR11207; 1.
DR Pfam; PF00035; dsrm; 1.
DR Pfam; PF00636; Ribonuclease_3; 1.
DR SMART; SM00358; DSRM; 1.
DR SMART; SM00535; RIBOc; 1.
DR SUPFAM; SSF69065; RNase_III; 1.
DR TIGRFAMs; TIGR02191; RNaseIII; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium;
KW Metal-binding; mRNA processing; Nuclease; RNA-binding;
KW rRNA processing; rRNA-binding; tRNA processing.
FT CHAIN 1 237 Ribonuclease 3.
FT /FTId=PRO_0000180387.
FT DOMAIN 7 135 RNase III.
FT DOMAIN 160 229 DRBM.
FT ACT_SITE 52 52 Potential.
FT ACT_SITE 124 124 By similarity.
FT METAL 48 48 Magnesium (By similarity).
FT METAL 121 121 Magnesium (By similarity).
FT METAL 124 124 Magnesium (By similarity).
FT CONFLICT 94 94 M -> V (in Ref. 4; AAP97988).
SQ SEQUENCE 237 AA; 26088 MW; EF9E79A5739EDAAE CRC64;
MHPPIDITAI EAKLNFTFTQ PKLLEIALTH PSYKNESAVQ IEDSERLEFL GDAVLGLIVT
EHLFLLFPSM DEGTLSTARA SLVNAKACCR YTTMLGIGDY LLIGKGEKIQ SERGRLSAYA
NLFESILGAV YLDGGLSPAR KLTVPLLPPR EEILPLMSGN PKNLLQQFTQ KQFRVLPVYQ
STAVTDAQGN VSYQIQVLVN QEVWGEGNAS SKKEAEKIAA QQALDTYGNK NQNTMDV
//
