ID   AK_RICPR                Reviewed;         446 AA.
AC   Q9ZCI7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   01-MAY-2013, entry version 76.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=RP753;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O.,
RA   Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K.,
RA   Eriksson A.-S., Winkler H.H., Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
RN   [2]
RP   DOMAIN RPE1.
RX   PubMed=11030655; DOI=10.1126/science.290.5490.347;
RA   Ogata H., Audic S., Barbe V., Artiguenave F., Fournier P.-E.,
RA   Raoult D., Claverie J.-M.;
RT   "Selfish DNA in protein-coding genes of Rickettsia.";
RL   Science 290:347-350(2000).
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC   -!- SIMILARITY: Contains 1 RPE1 insert domain.
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DR   EMBL; AJ235273; CAA15181.1; -; Genomic_DNA.
DR   PIR; E71635; E71635.
DR   RefSeq; NP_221105.1; NC_000963.1.
DR   ProteinModelPortal; Q9ZCI7; -.
DR   STRING; 272947.RP753; -.
DR   EnsemblBacteria; CAA15181; CAA15181; CAA15181.
DR   GeneID; 883748; -.
DR   KEGG; rpr:RP753; -.
DR   PATRIC; 17902367; VBIRicPro72556_0787.
DR   eggNOG; COG0527; -.
DR   HOGENOM; HOG000293093; -.
DR   KO; K00928; -.
DR   OMA; VANMITY; -.
DR   ProtClustDB; PRK06635; -.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004349; F:glutamate 5-kinase activity; IEA:InterPro.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase_dom.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR001057; Glu/AcGlu_kinase.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 1.
DR   PRINTS; PR00474; GLU5KINASE.
DR   SUPFAM; SSF53633; Aa_kinase; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome;
KW   Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN         1    446       Aspartokinase.
FT                                /FTId=PRO_0000066680.
FT   DOMAIN      250    294       RPE1 insert.
SQ   SEQUENCE   446 AA;  49773 MW;  76E118506A4E3D86 CRC64;
     MALIIQKFGG TSVANVERIK KLVPIIKAEI AKNNQVIVVV SAMAGVTNQL VTLCNEVSSL
     NKRSQFAEYD VALSSGEIVT ASLLALALQE EEIKAQSLLA WQLPIRTNNN YSKALVEFIT
     TDLLEKYLQL KIIPIIAGFQ GINKSNRVTT LGRGGSDTTA ALIAAAMKAD RCDIYTDVDG
     IFTADPRIIP NAKRIKEIDF LEMLELASSG AKVLHPRAVE LVMRYKIDMR VLSTFSPNTE
     GTLITSKDTI PLVKSTYMEE SALNTKHSTK IDIPEDASGS TYKLPIELAL QNRYNMENCV
     VRCITSNKNL LKVSVNSISL SFLQVANMIT YNNNCIEFMQ EIENNIEYNF ITNLTDKNNL
     QTLLTKCKNN KQIQDFTFDT EIATISLIGY GIKNDCKLLT MILSQLTQDN INVHMMQLSE
     VKITLLINDK DVEKTIFNLY NLFKIS
//