ID SILR_SALTM Reviewed; 228 AA.
AC Q9ZHD3;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 01-MAY-2013, entry version 72.
DE RecName: Full=Probable transcriptional regulatory protein SilR;
GN Name=silR;
OS Salmonella typhimurium.
OG Plasmid pMG101.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9930866; DOI=10.1038/5545;
RA Gupta A., Matsui K., Lo J.-F., Silver S.;
RT "Molecular basis for resistance to silver cations in Salmonella.";
RL Nat. Med. 5:183-188(1999).
CC -!- FUNCTION: Component of the sil cation-efflux system that confers
CC resistance to silver. Probable member of a two-component
CC regulatory system SilS/SilR.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC -!- PTM: Phosphorylated by SilS (Potential).
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; AF067954; AAD11745.1; -; Genomic_DNA.
DR ProteinModelPortal; Q9ZHD3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR006291; Sig_transdc_resp-reg_metal.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; Bipartite_resp_reg_C-effector; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Phosphoprotein; Plasmid; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1 228 Probable transcriptional regulatory
FT protein SilR.
FT /FTId=PRO_0000081224.
FT DOMAIN 1 116 Response regulatory.
FT MOD_RES 51 51 4-aspartylphosphate (By similarity).
SQ SEQUENCE 228 AA; 25463 MW; CAE0EBB5E4082F51 CRC64;
MKILIVEDDI KTGEYLSKGL TEAGFVVDHA DNGLTGYHLA MTAEYDLVIL DIMLPDVNGW
DIIRMLRSAG KGMPVLLLTA LGTIEHRVKG LELGADDYLV KPFAFAELLA RVRTLLRRGN
TMITESQLKV ADLSVDLVSR KVSRAGNRIV LTSKEFSLLE FFIRHQGEVL PRSLIAFFMV
WVHEFLTADT NAIDVAVKRL RAKIDNDYGT KLNQTVRGVG YMLEIPDA
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