GenomeNet

Database: UniProt
Entry: Q9ZHS1
LinkDB: Q9ZHS1
Original site: Q9ZHS1 
ID   CTRA_BRUAB              Reviewed;         232 AA.
AC   Q9ZHS1; Q57BS3;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   06-JUL-2016, entry version 106.
DE   RecName: Full=Cell cycle response regulator CtrA;
DE   AltName: Full=Cell cycle transcriptional regulator A {ECO:0000303|PubMed:11929544};
GN   Name=ctrA; OrderedLocusNames=BruAb1_1586;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Devos D.P., Depiereux E., Letesson J.-J.;
RT   "Two-component cell cycle regulator in Brucella species.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS RESPONSE REGULATOR,
RP   ROLE IN CELL DIVISION, PHOSPHORYLATION AT ASP-51, DISRUPTION
RP   PHENOTYPE, AND MUTAGENESIS OF ASP-51.
RC   STRAIN=544 / Biovar 1;
RX   PubMed=11929544; DOI=10.1046/j.1365-2958.2002.02777.x;
RA   Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J.,
RA   Letesson J.J., De Bolle X.;
RT   "Plasticity of a transcriptional regulation network among alpha-
RT   proteobacteria is supported by the identification of CtrA targets in
RT   Brucella abortus.";
RL   Mol. Microbiol. 43:945-960(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/JB.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L.,
RA   Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison
RT   to the highly similar genomes of Brucella melitensis and Brucella
RT   suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   -!- FUNCTION: Component of a regulatory phosphorelay system that
CC       controls B.abortus cell growth, division, and intracellular
CC       survival inside mammalian host cells. This signaling pathway is
CC       composed of CckA, ChpT, CtrA and CpdR. CtrA is a response
CC       regulator substrate of ChpT (By similarity). When phosphorylated,
CC       directly regulates the expression of ccrM. Is also probably
CC       involved in the transcriptional regulation of rpoD, pleC, minC and
CC       ftsE genes (PubMed:11929544). {ECO:0000250|UniProtKB:Q2YQA4,
CC       ECO:0000269|PubMed:11929544}.
CC   -!- SUBUNIT: Forms an asymmetric heterotetramer with ChpT (2:2). There
CC       are at least two modes of interaction between ChpT and CtrA, only
CC       one of which is competent to catalyze His-Asp phosphoryl transfer.
CC       {ECO:0000250|UniProtKB:Q2YQA4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Is phosphorylated by ChpT-P on Asp-51.
CC       {ECO:0000250|UniProtKB:Q2YQA4, ECO:0000269|PubMed:11929544}.
CC   -!- DISRUPTION PHENOTYPE: Lethal. {ECO:0000269|PubMed:11929544}.
CC   -!- SIMILARITY: Contains 1 OmpR/PhoB-type DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU01091}.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00169}.
DR   EMBL; AF051939; AAC69920.1; -; mRNA.
DR   EMBL; AF411570; AAL86376.1; -; Genomic_DNA.
DR   EMBL; AE017223; AAX74911.1; -; Genomic_DNA.
DR   PIR; AI3304; AI3304.
DR   RefSeq; WP_002964699.1; NC_006932.1.
DR   ProteinModelPortal; Q9ZHS1; -.
DR   EnsemblBacteria; AAX74911; AAX74911; BruAb1_1586.
DR   GeneID; 3788674; -.
DR   KEGG; bmb:BruAb1_1586; -.
DR   PATRIC; 17824925; VBIBruAbo15061_1676.
DR   HOGENOM; HOG000034815; -.
DR   KO; K13584; -.
DR   OMA; YVLREPH; -.
DR   OrthoDB; EOG6G4VQG; -.
DR   BioCyc; BABO262698:GJC2-1617-MONOMER; -.
DR   Proteomes; UP000000540; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    232       Cell cycle response regulator CtrA.
FT                                /FTId=PRO_0000363197.
FT   DOMAIN        2    116       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DNA_BIND    124    223       OmpR/PhoB-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01091}.
FT   MOD_RES      51     51       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169,
FT                                ECO:0000269|PubMed:11929544}.
FT   MUTAGEN      51     51       D->E: No phosphorylation.
FT                                {ECO:0000269|PubMed:11929544}.
SQ   SEQUENCE   232 AA;  26066 MW;  9177C2281EC76ACE CRC64;
     MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL DLNLPDMSGY
     EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT KPFHKDELIA RIHAIVRRSK
     GHAQSVITTG DLVVNLDAKT VEVAGQRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
     GMDEPELKII DVFICKLRKK LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA
//
DBGET integrated database retrieval system