ID CTRA_BRUAB Reviewed; 232 AA.
AC Q9ZHS1; Q57BS3;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 01-MAY-2013, entry version 91.
DE RecName: Full=Cell cycle response regulator CtrA;
GN Name=ctrA; OrderedLocusNames=BruAb1_1586;
OS Brucella abortus biovar 1 (strain 9-941).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Brucellaceae; Brucella.
OX NCBI_TaxID=262698;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Devos D.P., Depiereux E., Letesson J.-J.;
RT "Two-component cell cycle regulator in Brucella species.";
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS RESPONSE REGULATOR,
RP ROLE IN CELL DIVISION, PHOSPHORYLATION, DISRUPTION PHENOTYPE, AND
RP MUTAGENESIS OF ASP-51.
RC STRAIN=544 / Biovar 1;
RX PubMed=11929544; DOI=10.1046/j.1365-2958.2002.02777.x;
RA Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J.,
RA Letesson J.J., De Bolle X.;
RT "Plasticity of a transcriptional regulation network among alpha-
RT proteobacteria is supported by the identification of CtrA targets in
RT Brucella abortus.";
RL Mol. Microbiol. 43:945-960(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9-941;
RX PubMed=15805518; DOI=10.1128/JB.187.8.2715-2726.2005;
RA Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L.,
RA Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT "Completion of the genome sequence of Brucella abortus and comparison
RT to the highly similar genomes of Brucella melitensis and Brucella
RT suis.";
RL J. Bacteriol. 187:2715-2726(2005).
CC -!- FUNCTION: Essential protein that plays a role in the control of
CC cell division, possibly through the transcriptional regulation of
CC ccrM, rpoD, pleC, minC and ftsZ genes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC -!- DISRUPTION PHENOTYPE: Lethal.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; AF051939; AAC69920.1; -; mRNA.
DR EMBL; AF411570; AAL86376.1; -; Genomic_DNA.
DR EMBL; AE017223; AAX74911.1; -; Genomic_DNA.
DR PIR; AI3304; AI3304.
DR RefSeq; YP_222272.1; NC_006932.1.
DR ProteinModelPortal; Q9ZHS1; -.
DR STRING; 262698.BruAb1_1586; -.
DR EnsemblBacteria; AAX74911; AAX74911; BruAb1_1586.
DR GeneID; 3339612; -.
DR KEGG; bmb:BruAb1_1586; -.
DR PATRIC; 17824925; VBIBruAbo15061_1676.
DR eggNOG; COG0745; -.
DR HOGENOM; HOG000034815; -.
DR KO; K13584; -.
DR OMA; PDMNGHE; -.
DR ProtClustDB; CLSK863578; -.
DR BioCyc; BABO262698:GJC2-1617-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 232 Cell cycle response regulator CtrA.
FT /FTId=PRO_0000363197.
FT DOMAIN 2 116 Response regulatory.
FT MOD_RES 51 51 4-aspartylphosphate.
FT MUTAGEN 51 51 D->E: No phosphorylation.
SQ SEQUENCE 232 AA; 26066 MW; 9177C2281EC76ACE CRC64;
MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL DLNLPDMSGY
EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT KPFHKDELIA RIHAIVRRSK
GHAQSVITTG DLVVNLDAKT VEVAGQRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
GMDEPELKII DVFICKLRKK LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA
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