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Database: UniProt
Entry: Q9ZHS1
LinkDB: Q9ZHS1
Original site: Q9ZHS1 
ID   CTRA_BRUAB              Reviewed;         232 AA.
AC   Q9ZHS1; Q57BS3;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   14-MAY-2014, entry version 96.
DE   RecName: Full=Cell cycle response regulator CtrA;
GN   Name=ctrA; OrderedLocusNames=BruAb1_1586;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Devos D.P., Depiereux E., Letesson J.-J.;
RT   "Two-component cell cycle regulator in Brucella species.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS RESPONSE REGULATOR,
RP   ROLE IN CELL DIVISION, PHOSPHORYLATION, DISRUPTION PHENOTYPE, AND
RP   MUTAGENESIS OF ASP-51.
RC   STRAIN=544 / Biovar 1;
RX   PubMed=11929544; DOI=10.1046/j.1365-2958.2002.02777.x;
RA   Bellefontaine A.F., Pierreux C.E., Mertens P., Vandenhaute J.,
RA   Letesson J.J., De Bolle X.;
RT   "Plasticity of a transcriptional regulation network among alpha-
RT   proteobacteria is supported by the identification of CtrA targets in
RT   Brucella abortus.";
RL   Mol. Microbiol. 43:945-960(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/JB.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L.,
RA   Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison
RT   to the highly similar genomes of Brucella melitensis and Brucella
RT   suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   -!- FUNCTION: Essential protein that plays a role in the control of
CC       cell division, possibly through the transcriptional regulation of
CC       ccrM, rpoD, pleC, minC and ftsZ genes.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- DISRUPTION PHENOTYPE: Lethal.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
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DR   EMBL; AF051939; AAC69920.1; -; mRNA.
DR   EMBL; AF411570; AAL86376.1; -; Genomic_DNA.
DR   EMBL; AE017223; AAX74911.1; -; Genomic_DNA.
DR   PIR; AI3304; AI3304.
DR   RefSeq; YP_222272.1; NC_006932.1.
DR   ProteinModelPortal; Q9ZHS1; -.
DR   STRING; 262698.BruAb1_1586; -.
DR   EnsemblBacteria; AAX74911; AAX74911; BruAb1_1586.
DR   GeneID; 3339612; -.
DR   KEGG; bmb:BruAb1_1586; -.
DR   PATRIC; 17824925; VBIBruAbo15061_1676.
DR   eggNOG; COG0745; -.
DR   HOGENOM; HOG000034815; -.
DR   KO; K13584; -.
DR   OMA; GISEMDS; -.
DR   OrthoDB; EOG6G4VQG; -.
DR   BioCyc; BABO262698:GJC2-1617-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    232       Cell cycle response regulator CtrA.
FT                                /FTId=PRO_0000363197.
FT   DOMAIN        2    116       Response regulatory.
FT   MOD_RES      51     51       4-aspartylphosphate.
FT   MUTAGEN      51     51       D->E: No phosphorylation.
SQ   SEQUENCE   232 AA;  26066 MW;  9177C2281EC76ACE CRC64;
     MRVLLIEDDS AIAQSIELML KSESFNVYTT DLGEEGIDLG KLYDYDIILL DLNLPDMSGY
     EVLRTLRLSK VKTPILILSG MAGIEDKVRG LGFGADDYMT KPFHKDELIA RIHAIVRRSK
     GHAQSVITTG DLVVNLDAKT VEVAGQRVHL TGKEYQMLEL LSLRKGTTLT KEMFLNHLYG
     GMDEPELKII DVFICKLRKK LDAVSGNQSY IETVWGRGYV LREPDAEMRE SA
//
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