ID   Y347_HELPJ              Reviewed;         293 AA.
AC   Q9ZMA1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   01-MAY-2013, entry version 71.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase jhp_0321;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=jhp_0321;
OS   Helicobacter pylori (strain J99) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G.,
RA   Tummino P.J., Caruso A., Uria-Nickelsen M., Mills D.M., Ives C.,
RA   Gibson R., Merberg D., Mills S.D., Jiang Q., Taylor D.E., Vovis G.F.,
RA   Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human
RT   gastric pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- CATALYTIC ACTIVITY: RNA uridine = RNA pseudouridine.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE001439; AAD05911.1; -; Genomic_DNA.
DR   PIR; A71946; A71946.
DR   RefSeq; NP_223040.1; NC_000921.1.
DR   ProteinModelPortal; Q9ZMA1; -.
DR   STRING; 85963.jhp0321; -.
DR   EnsemblBacteria; AAD05911; AAD05911; jhp_0321.
DR   GeneID; 889306; -.
DR   KEGG; hpj:jhp0321; -.
DR   PATRIC; 20605300; VBIHelPyl98156_0358.
DR   eggNOG; COG0564; -.
DR   KO; K06180; -.
DR   OMA; IEREFTI; -.
DR   ProtClustDB; CLSK872338; -.
DR   BioCyc; HPYL85963:GJB9-331-MONOMER; -.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; PsdUridine_synth_cat_dom; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase.
FT   CHAIN         1    293       Uncharacterized RNA pseudouridine
FT                                synthase jhp_0321.
FT                                /FTId=PRO_0000162734.
FT   ACT_SITE    119    119       By similarity.
SQ   SEQUENCE   293 AA;  33668 MW;  D7EF3EC54A8E6168 CRC64;
     MPFVEEEFEI LKPTKALFLV RDVLKCSLKE AQRHLDKQRL KQNQQTVRKS QIIQGVVRLI
     YFKPNEKQEK LVFEAKDFGV FDKPAQIYTH PKGYFYHESL LDCIQSHFGK NAHPAHRLDY
     ETSGLVLAGK TLQSTKDLKA LFMQKKVKKT YLALAHGLVD KSIIINKPIL TPQNIQKDLR
     IRSQISPLGK PSITLVEPLS YNPFLDISLL KITPLTGRTH QIRLHLSSVD HRIVGEGLYG
     VADENAREYL QLKRENNAPT LMLHAASLEF EFKGAHYKIA SPMPERFMPF LKD
//