ID Q9ZR58_SOLLC Unreviewed; 1114 AA.
AC Q9ZR58;
DT 01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT 01-MAY-1999, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN Name=RdRP {ECO:0000313|EMBL:CAA71421.1};
GN Synonyms=544124 {ECO:0000313|EnsemblPlants:Solyc05g007510.3.1};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EMBL:CAA71421.1};
RN [1] {ECO:0000313|EMBL:CAA71421.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Rutgers {ECO:0000313|EMBL:CAA71421.1};
RX PubMed=9836747; DOI=10.1105/tpc.10.12.2087;
RA Schiebel W., Pelissier T., Riedel L., Thalmeir S., Schiebel R., Kempe D.,
RA Lottspeich F., Saenger H.L., Wassenegger M.;
RT "Isolation of an RNA-directed RNA polymerase-specific cDNA clone from
RT tomato.";
RL Plant Cell 10:2087-2101(1998).
RN [2] {ECO:0000313|EnsemblPlants:Solyc05g007510.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc05g007510.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [3] {ECO:0000313|EnsemblPlants:Solyc05g007510.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc05g007510.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- FUNCTION: Probably involved in the RNA silencing pathway and required
CC for the generation of small interfering RNAs (siRNAs).
CC {ECO:0000256|RuleBase:RU363098}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC ECO:0000256|RuleBase:RU363098};
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC ECO:0000256|RuleBase:RU363098}.
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DR EMBL; Y10403; CAA71421.1; -; mRNA.
DR PIR; T30819; T30819.
DR RefSeq; NP_001234319.1; NM_001247390.2.
DR AlphaFoldDB; Q9ZR58; -.
DR SMR; Q9ZR58; -.
DR STRING; 4081.Q9ZR58; -.
DR PaxDb; 4081-Solyc05g007510-2-1; -.
DR EnsemblPlants; Solyc05g007510.3.1; Solyc05g007510.3.1; Solyc05g007510.3.
DR GeneID; 544124; -.
DR Gramene; Solyc05g007510.3.1; Solyc05g007510.3.1; Solyc05g007510.3.
DR KEGG; sly:544124; -.
DR eggNOG; KOG0988; Eukaryota.
DR HOGENOM; CLU_001366_3_0_1; -.
DR InParanoid; Q9ZR58; -.
DR OMA; CYNEGYE; -.
DR OrthoDB; 5477883at2759; -.
DR BRENDA; 2.7.7.48; 3101.
DR Proteomes; UP000004994; Chromosome 5.
DR ExpressionAtlas; Q9ZR58; baseline and differential.
DR GO; GO:0031380; C:nuclear RNA-directed RNA polymerase complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IBA:GO_Central.
DR GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR CDD; cd00590; RRM_SF; 1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF05183; RdRP; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 2: Evidence at transcript level;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098,
KW ECO:0000313|EMBL:CAA71421.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU363098};
KW RNA-mediated gene silencing {ECO:0000256|RuleBase:RU363098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
SQ SEQUENCE 1114 AA; 126808 MW; B6D30ACD41DB37FF CRC64;
MGKTIQVFGF PYLLSAEVVK SFLEKYTGYG TVCALEVKQS KGGSRAFAKV QFADNISADK
IITLANNRLY FGSSYLKAWE MKTDIVQLRA YVDQMDGITL NFGCQISDDK FAVLGSTEVS
IQFGIGLKKF FFFLSSGSAD YKLQLSYENI WQVVLHRPYG QNAQFLLIQL FGAPRIYKRL
ENSCYSFFKE TPDDQWVRTT DFPPSWIGLS SSLCLQFRRG VRLPNFEESF FHYAERENNI
TLQTGFTFFV SQKSALVPNV QPPEGISIPY KILFKISSLV QHGCIPGPAL NVYFFRLVDP
RRRNVACIEH ALEKLYYIKE CCYDPVRWLT EQYDGYLKGR QPPKSPSITL DDGLVYVRRV
LVTPCKVYFC GPEVNVSNRV LRNYSEDIDN FLRVSFVDEE WEKLYSTDLL PKASTGSGVR
TNIYERILST LRKGFVIGDK KFEFLAFSSS QLRDNSVWMF ASRPGLTAND IRAWMGDFSQ
IKNVAKYAAR LGQSFGSSRE TLSVLRHEIE VIPDVKVHGT SYVFSDGIGK ISGDFAHRVA
SKCGLQYTPS AFQIRYGGYK GVVGVDPDSS MKLSLRKSMS KYESDNIKLD VLGWSKYQPC
YLNRQLITLL STLGVKDEVL EQKQKEAVDQ LDAILHDSLK AQEALELMSP GENTNILKAM
LNCGYKPDAE PFLSMMLQTF RASKLLDLRT RSRIFIPNGR TMMGCLDESR TLEYGQVFVQ
FTGAGHGEFS DDLHPFNNSR STNSNFILKG NVVVAKNPCL HPGDIRVLKA VNVRALHHMV
DCVVFPQKGK RPHPNECSGS DLDGDIYFVC WDQDMIPPRQ VQPMEYPPAP SIQLDHDVTI
EEVEEYFTNY IVNDSLGIIA NAHVVFADRE PDMAMSDPCK KLAELFSIAV DFPKTGVPAE
IPSQLRPKEY PDFMDKPDKT SYISERVIGK LFRKVKDKAP QASSIATFTR DVARRSYDAD
MEVDGFEDYI DEAFDYKTEY DNKLGNLMDY YGIKTEAEIL SGGIMKASKT FDRRKDAEAI
SVAVRALRKE ARAWFKRRND IDDMLPKASA WYHVTYHPTY WGCYNQGLKR AHFISFPWCV
YDQLIQIKKD KARNRPVLNL SSLRAQLSHR LVLK
//
