ID COX2_SQUAC Reviewed; 230 AA.
AC Q9ZZ51;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 01-MAY-2013, entry version 77.
DE RecName: Full=Cytochrome c oxidase subunit 2;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide II;
GN Name=MT-CO2; Synonyms=COII, COXII, MTCO2;
OS Squalus acanthias (Spiny dogfish).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Squalimorphii; Squaliformes; Squalidae; Squalus.
OX NCBI_TaxID=7797;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9873084; DOI=10.1007/PL00006439;
RA Rasmussen A.S., Arnason U.;
RT "Phylogenetic studies of complete mitochondrial DNA molecules place
RT cartilaginous fishes within the tree of bony fishes.";
RL J. Mol. Evol. 48:118-123(1999).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. Subunit 2
CC transfers the electrons from cytochrome c via its binuclear copper
CC A center to the bimetallic center of the catalytic subunit 1.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- COFACTOR: Copper A.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
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DR EMBL; Y18134; CAA77052.1; -; Genomic_DNA.
DR PIR; T11537; T11537.
DR RefSeq; NP_008526.1; NC_002012.1.
DR ProteinModelPortal; Q9ZZ51; -.
DR SMR; Q9ZZ51; 1-227.
DR GeneID; 808387; -.
DR CTD; 4513; -.
DR HOVERGEN; HBG012727; -.
DR ProtClustDB; MTH00185; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.90; -; 1.
DR Gene3D; 2.60.40.420; -; 1.
DR InterPro; IPR001505; Copper_CuA.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR014222; Cyt_c_oxidase_su2.
DR InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR Pfam; PF00116; COX2; 1.
DR Pfam; PF02790; COX2_TM; 1.
DR SUPFAM; SSF49503; Cupredoxin; 1.
DR SUPFAM; SSF81464; Cyt_c_oxidase_II-like_TM; 1.
DR TIGRFAMs; TIGR02866; CoxB; 1.
DR PROSITE; PS00078; COX2; 1.
DR PROSITE; PS50857; COX2_CUA; 1.
DR PROSITE; PS50999; COX2_TM; 1.
PE 3: Inferred from homology;
KW Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 230 Cytochrome c oxidase subunit 2.
FT /FTId=PRO_0000183695.
FT TOPO_DOM 1 26 Mitochondrial intermembrane (Potential).
FT TRANSMEM 27 48 Helical; (Potential).
FT TOPO_DOM 49 62 Mitochondrial matrix (Potential).
FT TRANSMEM 63 82 Helical; (Potential).
FT TOPO_DOM 83 230 Mitochondrial intermembrane (Potential).
FT METAL 161 161 Copper A (Probable).
FT METAL 196 196 Copper A (Probable).
FT METAL 200 200 Copper A (Probable).
FT METAL 204 204 Copper A (Probable).
SQ SEQUENCE 230 AA; 26247 MW; AC04C362577055A4 CRC64;
MAHPSQLGFQ DAASPVMEEL LHFHDHTLMI VFLISTLVLY IIMAMVSTKL TNKYILDSQE
IEIVWTILPA VILIMIALPS LRILYLMDEI NDPHLTIKAM GHQWYWSYEY TDYEDLGFDS
YMIQTQDLTP GQFRLLETDH RMVVPMESPI RVLVSAEDVL HSWTVPALGV KMDAVPGRLN
QTAFIISRPG VYYGQCSEIC GANHSFMPIV VEAVPLEHFE SWSSLMLEEA
//
