GenomeNet

Database: UniProt
Entry: Q9ZZ51
LinkDB: Q9ZZ51
Original site: Q9ZZ51 
ID   COX2_SQUAC              Reviewed;         230 AA.
AC   Q9ZZ51;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   01-OCT-2014, entry version 83.
DE   RecName: Full=Cytochrome c oxidase subunit 2;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide II;
GN   Name=MT-CO2; Synonyms=COII, COXII, MTCO2;
OS   Squalus acanthias (Spiny dogfish).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalimorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9873084; DOI=10.1007/PL00006439;
RA   Rasmussen A.S., Arnason U.;
RT   "Phylogenetic studies of complete mitochondrial DNA molecules place
RT   cartilaginous fishes within the tree of bony fishes.";
RL   J. Mol. Evol. 48:118-123(1999).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. Subunit 2
CC       transfers the electrons from cytochrome c via its binuclear copper
CC       A center to the bimetallic center of the catalytic subunit 1.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- COFACTOR: Copper A.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 2 family.
CC       {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; Y18134; CAA77052.1; -; Genomic_DNA.
DR   PIR; T11537; T11537.
DR   RefSeq; NP_008526.1; NC_002012.1.
DR   ProteinModelPortal; Q9ZZ51; -.
DR   SMR; Q9ZZ51; 1-227.
DR   GeneID; 808387; -.
DR   CTD; 4513; -.
DR   HOVERGEN; HBG012727; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045277; C:respiratory chain complex IV; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   Gene3D; 1.10.287.90; -; 1.
DR   Gene3D; 2.60.40.420; -; 1.
DR   InterPro; IPR001505; Copper_CuA.
DR   InterPro; IPR008972; Cupredoxin.
DR   InterPro; IPR014222; Cyt_c_oxidase_su2.
DR   InterPro; IPR002429; Cyt_c_oxidase_su2_C.
DR   InterPro; IPR011759; Cyt_c_oxidase_su2_TM_dom.
DR   Pfam; PF00116; COX2; 1.
DR   Pfam; PF02790; COX2_TM; 1.
DR   SUPFAM; SSF49503; SSF49503; 1.
DR   SUPFAM; SSF81464; SSF81464; 1.
DR   TIGRFAMs; TIGR02866; CoxB; 1.
DR   PROSITE; PS00078; COX2; 1.
DR   PROSITE; PS50857; COX2_CUA; 1.
DR   PROSITE; PS50999; COX2_TM; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Respiratory chain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    230       Cytochrome c oxidase subunit 2.
FT                                /FTId=PRO_0000183695.
FT   TOPO_DOM      1     26       Mitochondrial intermembrane.
FT                                {ECO:0000255}.
FT   TRANSMEM     27     48       Helical. {ECO:0000255}.
FT   TOPO_DOM     49     62       Mitochondrial matrix. {ECO:0000255}.
FT   TRANSMEM     63     82       Helical. {ECO:0000255}.
FT   TOPO_DOM     83    230       Mitochondrial intermembrane.
FT                                {ECO:0000255}.
FT   METAL       161    161       Copper A. {ECO:0000305}.
FT   METAL       196    196       Copper A. {ECO:0000305}.
FT   METAL       200    200       Copper A. {ECO:0000305}.
FT   METAL       204    204       Copper A. {ECO:0000305}.
SQ   SEQUENCE   230 AA;  26247 MW;  AC04C362577055A4 CRC64;
     MAHPSQLGFQ DAASPVMEEL LHFHDHTLMI VFLISTLVLY IIMAMVSTKL TNKYILDSQE
     IEIVWTILPA VILIMIALPS LRILYLMDEI NDPHLTIKAM GHQWYWSYEY TDYEDLGFDS
     YMIQTQDLTP GQFRLLETDH RMVVPMESPI RVLVSAEDVL HSWTVPALGV KMDAVPGRLN
     QTAFIISRPG VYYGQCSEIC GANHSFMPIV VEAVPLEHFE SWSSLMLEEA
//
DBGET integrated database retrieval system