ID R0I4K4_9BRAS Unreviewed; 1101 AA.
AC R0I4K4;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN ORFNames=CARUB_v10016251mg {ECO:0000313|EMBL:EOA32925.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA32925.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PP2C family.
CC {ECO:0000256|RuleBase:RU003465}.
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DR EMBL; KB870807; EOA32925.1; -; Genomic_DNA.
DR RefSeq; XP_006300027.1; XM_006299965.1.
DR AlphaFoldDB; R0I4K4; -.
DR STRING; 81985.R0I4K4; -.
DR GeneID; 17892975; -.
DR KEGG; crb:17892975; -.
DR eggNOG; KOG0616; Eukaryota.
DR eggNOG; KOG0698; Eukaryota.
DR eggNOG; KOG1113; Eukaryota.
DR OrthoDB; 1061429at2759; -.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd00143; PP2Cc; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000222; PP2C_BS.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR24353; CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE; 1.
DR PANTHER; PTHR24353:SF127; PROTEIN PHOSPHATASE 2C AND CYCLIC NUCLEOTIDE-BINDING_KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00481; PP2C; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00332; PP2Cc; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS01032; PPM_1; 1.
DR PROSITE; PS51746; PPM_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003465};
KW Kinase {ECO:0000256|ARBA:ARBA00022527};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912,
KW ECO:0000256|RuleBase:RU003465};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 114..404
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT DOMAIN 498..607
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 624..750
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 789..1045
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 1101 AA; 122294 MW; 88BC3A847EB391E6 CRC64;
MGCAYSKTCI GQICATKENS IRHTHHQQAP ARVGAGTRTP NATAAAAVEE DNNPVFNFSS
DAVDDDEDNH EIHQLSLSRD QEWGITRLSR VSSQFLPPDG SRVVKVPSCN YELRYSFLSQ
RGYYPDALDK ANQDSFAIHT PFGSNSDDHF FGVFDGHGEF GAQCSQFVKR KLCENLLRHG
RFRVDPAEAC NTAFLSTNSQ LHADVVDDSM SGTTAITVMV RGRTIYVANA GDSRAVLAEK
RDGDLVAVDL SIDQTPFRPD ELERVKLCGA RVLTLDQIEG LKNPDVQCWG TEEDDDGDPP
RLWIPNGMYP GTAFTRSIGD SIAETIGVVA NPEIAVVELT PDNPFFVVAS DGVFEFISSQ
TVVDMVAKHK DPRDACAAIV AESYRLWLQY ETRTDDITII VVHISGLKDD APRQLSSTGT
LLQPPTPQVV ELTGSESPST FGWNSKNQRV RHDLSRARIR AIESSLENGH AWVPPSPAHR
KTWEEEAHIE RVLRDHFLFR KLTDSQCQVL LDCMQRLEAN PGDVVVKQGG EGDCFYVVGS
GEFEVLATQD EKNGEVPRIL QRYTAEKQSS FGELALMHNK PLQASVRAVD HGTLWALKRE
DFRGILMSEF SNLASLKLLR SVDLLSRLTI LQLSHVAESL SEACFSDGQT IVTKDEKLQG
LYVIQKGLVR ITFGTEVLES QNISSLKTEI TKEYENAEIG TEVSIEKQEG SYFGEWALLG
ELKDSLSVVA VGDVVCVILT KENFESAVGP LTNLTDDSHK SRHSSFDLSK EPAKVTDTTA
LAKATLADLE WTTCLSSTDC SEIGLVQLKD KENLLSLKRF SKQKVKKLGK EAQVLKERNL
MKNVIKASAF VPEILCTCVD ETFAAILLNA TLACPISSLL HSPLDESSAR FITASLVSAL
EDIHKNEILF RGSSPELLML DQSGYLQVVD FRFAKKLSGE RTFTICGNAD YLAPEIVQGK
GHGFAADWWA LGVLIYYMLE GEMPFGSWRE SELDTFQKIA KGQLTFPRAL SYEAEDLIAK
LLEVDENLRF GSQGGPESIK KHPWFNGLKW EAISNREFEV PQEIMSRIHH HLENDTVLPL
ETAQSLDTTD DKDARNWLEE W
//
