ID R0I7N9_9BRAS Unreviewed; 491 AA.
AC R0I7N9;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=CARUB_v10021591mg {ECO:0000313|EMBL:EOA34090.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA34090.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KB870806; EOA34090.1; -; Genomic_DNA.
DR RefSeq; XP_006301192.1; XM_006301130.1.
DR AlphaFoldDB; R0I7N9; -.
DR STRING; 81985.R0I7N9; -.
DR GeneID; 17896437; -.
DR KEGG; crb:17896437; -.
DR eggNOG; KOG1430; Eukaryota.
DR OrthoDB; 3675908at2759; -.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028110; TMEM254.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF14934; TMEM254; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029121};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 376..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..287
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 491 AA; 54502 MW; 2389D167FD5560CC CRC64;
MKEEENKGIE GKVVAVTGGL GLVGSTVCLE LLRRGALQVR SFDCRTTSPW SDNLKESGVH
CIHGDVVSRE DVEEALQGVD LVIHLASYGG SGKEMIRTHR IEEVNVEGTR NVLETCVKKG
ITRLVYLSTN GVVSGGKELE NGDETLPYVP YNNYVSSYDR TKSIAEQLVL ENNGRVVENG
RGSLLSTCAI RCPIVYGPAE EKYLDRIISD ARLGLFLFKI GDASSKTDFI YVDNIVYALM
LATADLLNQH SKAAGKAYIV SDGNPINFFE FLRPLLMNLD YELPKSSLSI PVAVLLGKIC
EAIYTMLSPL LNQGWIPQPL ILPPEVYKVG VTHYYSIRKA KEELGYEPTT QPEEAMTKTN
SYFKDKKRRE VDGPSIYAWI FCVIGLPSII SVAWLPDIGP IPFFRVIALF IFRSMLVLRI
ASGIVVTTHV SEAVYALWLA RRVDPKNAKA WFWRTLLLAT FSLRLLLKRA KEAKQSTLRE
GLLTISGSSV A
//
