ID R0IR32_9BRAS Unreviewed; 770 AA.
AC R0IR32;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase {ECO:0000256|PIRNR:PIRNR037274};
DE EC=2.7.1.68 {ECO:0000256|PIRNR:PIRNR037274};
GN ORFNames=CARUB_v10008368mg {ECO:0000313|EMBL:EOA39723.1};
OS Capsella rubella.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Capsella.
OX NCBI_TaxID=81985 {ECO:0000313|EMBL:EOA39723.1, ECO:0000313|Proteomes:UP000029121};
RN [1] {ECO:0000313|Proteomes:UP000029121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Monte Gargano {ECO:0000313|Proteomes:UP000029121};
RX PubMed=23749190; DOI=10.1038/ng.2669;
RA Slotte T., Hazzouri K.M., Agren J.A., Koenig D., Maumus F., Guo Y.L.,
RA Steige K., Platts A.E., Escobar J.S., Newman L.K., Wang W., Mandakova T.,
RA Vello E., Smith L.M., Henz S.R., Steffen J., Takuno S., Brandvain Y.,
RA Coop G., Andolfatto P., Hu T.T., Blanchette M., Clark R.M., Quesneville H.,
RA Nordborg M., Gaut B.S., Lysak M.A., Jenkins J., Grimwood J., Chapman J.,
RA Prochnik S., Shu S., Rokhsar D., Schmutz J., Weigel D., Wright S.I.;
RT "The Capsella rubella genome and the genomic consequences of rapid mating
RT system evolution.";
RL Nat. Genet. 45:831-835(2013).
RN [2] {ECO:0000313|EMBL:EOA39723.1}
RP NUCLEOTIDE SEQUENCE.
RA Schmutz J., Prochnik S., Nordborg M., Weigel D., Rokhsar D., Wright S.;
RT "Genome sequencing of Capsella rubella.";
RL Nat. Genet. 0:0-0(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-
CC phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178,
CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;
CC Evidence={ECO:0000256|PIRNR:PIRNR037274};
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DR EMBL; KB870805; EOA39723.1; -; Genomic_DNA.
DR EMBL; KB870805; EOA39724.1; -; Genomic_DNA.
DR RefSeq; XP_006306825.1; XM_006306763.1.
DR RefSeq; XP_006306826.1; XM_006306764.1.
DR AlphaFoldDB; R0IR32; -.
DR STRING; 81985.R0IR32; -.
DR GeneID; 17900441; -.
DR KEGG; crb:17900441; -.
DR eggNOG; KOG0229; Eukaryota.
DR OrthoDB; 340426at2759; -.
DR Proteomes; UP000029121; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd17302; PIPKc_AtPIP5K_like; 1.
DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 4.
DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR017163; PIno-4-P-5_kinase_pln.
DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR InterPro; IPR023610; PInositol-4/5-P-5/4-kinase.
DR PANTHER; PTHR23086:SF104; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 7; 1.
DR PANTHER; PTHR23086; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1.
DR Pfam; PF02493; MORN; 8.
DR Pfam; PF01504; PIP5K; 1.
DR PIRSF; PIRSF037274; PIP5K_plant_prd; 1.
DR SMART; SM00698; MORN; 8.
DR SMART; SM00330; PIPKc; 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR PROSITE; PS51455; PIPK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR037274, ECO:0000256|PROSITE-
KW ProRule:PRU00781};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR037274};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037274, ECO:0000256|PROSITE-
KW ProRule:PRU00781}; Reference proteome {ECO:0000313|Proteomes:UP000029121};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037274}.
FT DOMAIN 345..766
FT /note="PIPK"
FT /evidence="ECO:0000259|PROSITE:PS51455"
SQ SEQUENCE 770 AA; 87950 MW; B8B658E999E8F046 CRC64;
MDMRSGDREF PNGDFYSGEV KGLLPHGKGK YVWSDGTTYE GDWDQGKISG KGKLIWSSGA
KYEGDFSGGY LHGYGTMTSP DESVYCGTWR MNVRHGLGRK EYCNSDLYDG SWKEGLQDGR
GSYSWTNGNR YIGSWKKGKM CERGVMRWAN GDLYDGFWLN GFRHGSGVYK FSDGCLYYGT
WSRGLKDGKG VFYPAGSKQP SLKKWCRSLE YDDTGKFVLS RSASVNVEEL RSSKTVTRSL
SVETSAGEMT NSGRISDRLT DDIWKSCDPP RDFTCHGPLS KSARFSRSGE SEGQDKNRIV
YEREYMQGVL IRETIMSSVD RSHKIKPPHR PKEVRARSLL TFLRGEHNYY LMLNLQLGIR
YTVGKITPVP RREVRASDFG KNARTKMFFP RDGSNFTPPH KSIDFSWKDY CPMVFRNLRE
MFKLDAAEYM MSICGDDGLT EISSPGKSGS IFYLSHDDRF VIKTLKKSEL QVLLKMLPKY
YEHVGDHENT LITKFFGVHR ITLKWGKKVR FVVMGNMFCT ELKIHRRYDL KGSSQGRFTE
KIKIQEKTTL KDLDLAYEFH MDKLLREALF KQIYLDCSFL ESLNIIDYSL LLGLHFRAPG
QLNDILEPPN AMSDQESVSS VDVGLTQEIY IPPKGLLLVT HEPNSVNTAP GPHIRGSTLR
AFSVGEQEVD LILPGTARLR VQLGVNMPAQ AHHKLIEDKE ESATIELFEV YDVVVYMGII
DILQEYNTKK KVEHTCKSLQ YDPMTISVTE PAIYSKRFVN FLHKVFPEER
//
