ID R0JBE3_ANAPL Unreviewed; 1046 AA.
AC R0JBE3;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Toll-like receptor 7 {ECO:0000313|EMBL:EOA94590.1};
DE Flags: Fragment;
GN ORFNames=Anapl_16177 {ECO:0000313|EMBL:EOA94590.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA94590.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KB744694; EOA94590.1; -; Genomic_DNA.
DR AlphaFoldDB; R0JBE3; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EOA94590.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1046
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004353436"
FT TRANSMEM 837..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 886..1030
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EOA94590.1"
FT NON_TER 1046
FT /evidence="ECO:0000313|EMBL:EOA94590.1"
SQ SEQUENCE 1046 AA; 120380 MW; 72BB51FCD87E7C1F CRC64;
VPHAETSNAL PFVLLFLFPL LLSGAWFPKS LPCDVEASEG SVRVDCSDRR LTEVPRGIPA
NATNLTLTIN HIPHIYPTSF AYLERLVEID FRCNCVPVRL GPKDHVCTRT PTIENGSFAA
LTRLKSLYLD ANQLSEIPRG LPSTLSLLSL EANSISSIQK ANLSELRNIE ILYLGQNCYY
RNPCNVSFEI EQTAFLDLKN LTVLSLKSNN ITHIPPNLSS TLKELYIYNN IIQEVQEYDL
SALHNLEILD LSGNCPRCYN APYPCVPCPN NALKIHSKAF YSLKKLRILR LHSNSLRNIP
SSWFKNTRNL EELDLSQNFL MKEIGDAQFL KFVPRLVELD LSFNFELQMY SPSLNLSKTF
STLSNLEILR IRGYVFKELK KENLYPLLNL RNLTVLDLGT NFIKVADLTV FKRFQALKVI
DLSVNKISPS SSESNSYGIC SNPRISVEQR NRQVLQEMHY FRYDEYGRSC KSKDKEANSY
RPSVNRDCLD YGKTLDLSRN NIFFISPSDF QDLDFLRCLN LSGNAISQTL NGSEFHYLSG
LKYLDFSNNR IDLLYSTAFE ELKLLEILDL SNNKHYFLAE GVTHVLNFMK NLAYLKKLMM
NENEISTSIS TGMESQSLKI LEFRGNRLDV LWMDGNARYL SFFKNLTNLE KLDISFNSLS
FLPSDVFEAM PPELKILNLT NNRLKAFKWG KLYLLKKLTT LDLSNNLLTT VPRELSNCTS
TLQELILRNN HIQRLTKYFL RGAIGLQYLD LSSNKIQIIK KSSFPENVIN NLKMLLLHGN
PFKCNCDAVW FVWWINQTQV TIPLLATDVT CAGPGAHKGK SLVFLDLYTC ELDTSYLIMY
ALSASAVLGF MVFAVMSHLY FWDVWYSYHY CTAKLKGYRR LPLQDTCYDA FIAFDNTDPA
VNEWVMTELV EKLEDQKTRK FNLCLEERDW LPGQPVFDNL SQSIQLSKKT IFVLTNKYIK
SGSFKTTFYM AHQRLLDEKI DVIILIFLEK ILQKSRYVRL RKRLCRSSVL EWPTNPRSQP
YFWQTLKNAI ATCNTLAYNN LLQETV
//