ID R0JIR5_ANAPL Unreviewed; 495 AA.
AC R0JIR5;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 03-MAY-2023, entry version 41.
DE SubName: Full=Rho GTPase-activating protein 10-like {ECO:0000313|EMBL:EOA97160.1};
DE Flags: Fragment;
GN ORFNames=Anapl_17276 {ECO:0000313|EMBL:EOA97160.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:EOA97160.1, ECO:0000313|Proteomes:UP000296049};
RN [1] {ECO:0000313|Proteomes:UP000296049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23749191; DOI=10.1038/ng.2657;
RA Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H., Gan S.,
RA Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q., Fairley S.,
RA Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A., Lee T.,
RA Kim K.W., Sheng Z., An Y., Searle S., Herrero J., Groenen M.A.,
RA Crooijmans R.P., Faraut T., Cai Q., Webster R.G., Aldridge J.R.,
RA Warren W.C., Bartschat S., Kehr S., Marz M., Stadler P.F., Smith J.,
RA Kraus R.H., Zhao Y., Ren L., Fei J., Morisson M., Kaiser P., Griffin D.K.,
RA Rao M., Pitel F., Wang J., Li N.;
RT "The duck genome and transcriptome provide insight into an avian influenza
RT virus reservoir species.";
RL Nat. Genet. 45:776-783(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB743759; EOA97160.1; -; Genomic_DNA.
DR AlphaFoldDB; R0JIR5; -.
DR Proteomes; UP000296049; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF3; RHO GTPASE-ACTIVATING PROTEIN 42; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000296049};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 297..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 187..296
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 312..495
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT COILED 147..181
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 495
FT /evidence="ECO:0000313|EMBL:EOA97160.1"
SQ SEQUENCE 495 AA; 58026 MW; C5868062862E45AA CRC64;
MAVQKFSQSL QDFQFECIGD AETDDEINIA QSLKEFARLL IAVEEERRRL DGKKKFDKES
EKYYSILEKH LNLSAKKKES HLQDADTQID REHQNFYEAS LEYVFKIQEV QEKKKFEFVE
PLLAFLQGLF TFYHEGYELA QEFAPYKQQL QFNLQNTRNN FESTRQEVER LMQRMKSANQ
DYRPPSQWTM EGYLYVQEKR PLGFTWVKHY CTYDKGTKTF TMSIAETKSG GKVNGLVTSS
PEIFKLKSCI RRKTDSIDKR FCFDIEVFER PGIITLQAFS ESNRKLWLEA MDGKEPVRIF
VILFYFYSFM TLFLNEAGFN FVRKCIYAVE TRGITILGLY RIGGVNSKVQ KLMNTIFSPK
SPPDMDIDME LWDNKTITSG LKNYLRCLSE PLMTFKLHKD FIVAVKSDDQ NYRVEAVHAL
VHKLPEKNRE MLDILIKHLV KVSLHSQQNL MTVSNLGVIF GPTLMRAQEE TVAAMMNIKF
QNIVVEILIE HYEKV
//
